I grew up in rural Oklahoma, where we had one neighbor over the hill, a nearby fishing pond, and beautiful scenery. Long story short: I was always — and still love to be — outside. That means I’m no stranger to one of the most dreaded insects: ticks. While not every tick bite carries disease, cases of tick-borne illnesses have more than doubled since 2000, according to the Centers for Disease Control and Prevention (CDC), including Lyme disease, babesiosis, and Rocky Mountain spotted fever, among others.

Kseniya Kobets, MD, director of cosmetic dermatology at Montefiore Einstein Advanced Care in New York, says that when it comes to choosing a tick repellent, it’s paramount to look for products containing ingredients approved by the Environmental Protection Agency (EPA) and the CDC. “EPA registration attests that repellents are tested for safety and effectiveness and their effect on the environment,” she says. “The CDC only recommends ingredients shown to decrease disease transmission, which is important for preventing tick-borne illnesses like Lyme. Unapproved products may be ineffective or cause irritation.”

Preventing a tick bite is preferable to treating one, and prevention starts with being aware of your surroundings, covering up with clothes, and choosing the right tick repellent. Our list includes doctor-recommended and health editor–vetted products that contain CDC- and EPA-approved ingredients for adults and kids. Ahead, discover how to treat skin, clothes, and gear with a variety of tick repellents — including sprays, wipes, and stickers (yes, stickers!).

When to Consult a Doctor

Most people can safely remove a tick at home. However, if a tick is attached in a sensitive or hard-to-reach area like the eyelid, ear canal, or back of the head, or if part of the tick breaks off during removal, you should see a doctor to ensure complete removal. If you develop a rash or fever in the weeks after experiencing a tick bite, consult a healthcare professional, and be sure to mention the tick bite and its location, and roughly where you were when you picked up the tick.

DEET Tick Repellent Sprays for All-Day Protection

If you’re planning an outside adventure in an area with a densely populated insect and tick population, you want to give yourself extra protection. Ben’s 100 Tick & Insect Repellent formula contains the highest concentration of DEET on the market: 98.11 percent. At this concentration, a single application provides the longest possible repellency (up to 10 hours) against ticks and other biting insects.

This tick repellent is specifically formulated for situations with severe insect presence, such as deep woods expeditions, areas with high tick populations, and regions where insect-borne diseases are prevalent. DEET is ideal for those prioritizing maximum protection and coverage longevity above all else.

Do note that this product does have a pungent chemical smell, as expected, and feels greasy on your skin.

For a tick repellent with DEET, we love Off! Sportsmen Deep Woods Insect Repellent 3, primarily due to its balanced 30 percent concentration and sweat-proof formula. This level is highly effective for robust, long-lasting protection against ticks (up to eight hours), making it ideal for more outdoor activities where tick exposure is high.

Plus, it means fewer reapplications if you’re outdoors hiking or being active in high temperatures.

“At 20 to 30 percent strength, DEET is effective against ticks,” says Dr. Kobets. “Try to look for products that last at least six to eight hours.”

Although higher concentrations of DEET exist, 30 percent hits the sweet spot, providing significant repellency without the excessive skin irritation or strong odor that can sometimes accompany products with 50 percent or more DEET. The aerosol spray bottle makes application on skin and clothes easy, but be careful if you wear synthetic fabrics, as DEET may stain or damage them. DEET can damage certain rubber, plastic, vinyl, or elastic materials such as contact lenses, eyeglass frames and lenses, cameras, watch crystals, painted and varnished surfaces, and certain synthetic or treated fabrics. DEET does not damage natural fibers like cotton and wool.

Plant-Based Tick Sprays for Peace of Mind

Many tick repellents also protect against mosquitoes and other small insects, and the Natrapel Lemon Eucalyptus spray is one of them. It contains OLE, a plant-based active ingredient registered with the EPA to prevent mosquito and tick bites.

“I like the natural smell and how much product you’re able to get on your body in just one [spray],” says editor Alexandra Klausner. Use it on your skin, gear, or clothing for all-around protection.

Picaridin Tick Repellents to Confuse Those Pesky Insects

A favorite among Everyday Health editors, the Sawyer Picaridin Insect Repellent provides long-lasting, effective protection (up to 12 hours) without the downsides often associated with DEET, such as skin irritation and potential toxicity, according to the CDC.

We use this product on ourselves and our kids, so we trust it enough to apply it directly to the skin.

This particular formula is nongreasy, nonsticky, and lacks a strong odor, making it highly appealing for direct skin application. Kobets says 20 percent concentration is effective, which this formula contains. As a bonus, it won’t damage plastics or synthetic fabrics, making it safe for use on clothing, gear, and skin.

Ranger Ready Repellent combines an effective 20 percent picaridin concentration with travel-friendly features. It offers long-lasting protection (up to 12 hours), which is crucial for travelers who need reliable protection without constant reapplications.

Importantly, picaridin is nondamaging to clothing, plastics, and gear, making it ideal for packing alongside luggage and electronics. Its no-scent formula is also a significant benefit when in close quarters during travel. Plus, it’s available in compact, Transportation Security Administration–compliant sizes, further cementing its status as a top travel companion. Our Everyday Health editors note that the trigger pump dispenser makes it easy to use without fear of spilling.

Tick Repellent Wipes and Stickers You Can Take With You

What kid wants to take the time to apply tick repellent when the great outdoors awaits them? I know mine doesn’t. The NatPat Natural Mosquito Repellent Patches are a blessing in disguise; they’re easy to apply, and kids think they’re getting a cool sticker just for fun. They contain ingredients like peppermint and cedarwood, which not only smell great, but help keep ticks away.

Apply the stickers onto shirts, hats, or backpacks for up to eight hours of protection.

Repel Insect Repellent Mosquito and Tick Wipes offer convenient application and an effective 12 percent picaridin concentration per wipe. The wipe format allows precise, controlled application, minimizing overspray and inhalation, and making it easy to target specific areas of the skin, especially for children (when applied by an adult).

The concentration per wipe ensures robust and reliable protection against ticks (up to 10 hours), making it appropriate for various outdoor activities. For quick, mess-free application on the go, especially when you want to avoid aerosols, these wipes are a standout solution.

Clothing and Gear Repellent for an Extra Layer of Protection

Treating clothes and gear with bug repellent is another important step in tick prevention. Our experts agreed permethrin-treated clothing is one of the best lines of defense against ticks. Permethrin bonds to fabric fibers and kills ticks on contact, providing an extra layer of protection beyond skin-applied repellents. Paul Arnaboldi, PhD, assistant professor of pathology, microbiology, and immunology at New York Medical College, explains that, “When ticks grab on to permethrin-treated clothing, they will fall off quickly rather than move around looking for a blood meal.”

This product is a leader among anti-tick clothing treatments because of its proven 0.5 percent permethrin concentration and its unique role as an insecticide for fabric, not as a repellent for skin.

“I used this on my back porch furniture and wow! It kept the bugs at bay, which is not easy to do here in humid, muggy Florida,” says writer Jen Sinclair.

This concentration is specifically formulated for clothing and gear, offering long-lasting effectiveness through multiple washes (up to six washes or approximately six weeks). Its ability to kill ticks before they can bite, combined with its safety for use on clothing (once the product has dried), makes it an invaluable tool for serious outdoor enthusiasts and those in high-risk insect areas.

Repel Permethrin Clothing and Gear Insect Repellent has an effective 0.5 percent permethrin concentration that is specifically designed to be applied to and bond with fabrics.

Similar to Sawyer’s offering, this product functions as an insecticide, killing ticks and other insects that come into contact with treated items.

Its winning edge for gear is its reliable performance with items like tents, sleeping bags, backpacks, and other outdoor equipment. This provides a crucial perimeter of protection around your campsite or outdoor setup, enhancing overall tick defense. The 0.5 percent concentration is the industry standard for consumer-level permethrin fabric treatments, ensuring efficacy without oversaturation.

It’s effective for up to two weeks before needing reapplication, unless the gear is exposed to rain.

In addition to treating your clothes, opt for clothing that doubles as barrier-based protection. This Royal Robbins shirt isn’t treated with chemicals to prevent ticks and mosquitoes; instead, the fabric is tightly woven, so insects can’t reach your skin, even if they want to. We love how the fabric also has SPF, so your skin is protected against the sun’s harmful rays. Editor Olivia Campbell found the recycled polyester shirt surprisingly lightweight and breathable, even in high temperatures. Note that it runs large; order your regular size if you prefer a looser fit, or size down for a more traditional fit.

Tick Removers and Tweezers

All the experts we spoke with say tweezers are the best tool for removing ticks. We like how this two-piece set includes slanted and pointed tweezers. The CDC recommends using fine-pointed tweezers, if possible, to grasp the tick as close to the skin’s surface without squeezing its body. Be sure to pull the tick away from the skin; don’t twist or jerk, as that may cause the tick’s mouth to break off into the skin.

Bite Relief You’ll Always Want On Hand

Itching, swelling, redness — an antihistamine like Benadryl can help reduce these symptoms and provide quick relief.

As someone who couldn’t swallow pills until adulthood (don’t judge me), I appreciate that these tablets are less than half an inch long. Children as young as 6 years old can take this medicine, and there’s a liquid form available, too. Benadryl makes a topical antihistamine itch relief gel if you prefer that route.

How Can You Prevent Tick Bites?

All of our experts agree: Be aware and savvy about your environment. Ticks tend to hang out in tall grass or wooded areas and attach lower on the body. Dr. Arnaboldi says it’s best to walk toward the center of trails and stay out of grassy, wooded areas. In addition to using a tick repellent product, you should wear long pants and socks when hiking or gardening — physical barriers matter just as much as chemical ones.

Wesley Long, MD, PhD, medical director of diagnostic microbiology at Houston Methodist in Texas, recommends treating clothing with permethrin and applying topical insect repellents containing DEET or picaridin as an additional line of defense.

Just note that DEET can be toxic to pets, and permethrin is toxic to cats, so be extra careful around your fur babies.

How Do You Check for Ticks?

“Do a full body check,” recommends Chris Harkin, MD, an urgent care physician in Madison, Wisconsin, and Janesville, Wisconsin. “Use a mirror or a partner and carefully inspect your body. Ticks often choose warm, hidden areas.” On adults, check the scalp and hairline with a comb, behind the ears, armpits, inside the belly button, around the waist and groin, behind the knees, and between the fingers and toes. On kids, check the hair, neck, behind the ears, the waist and groin, and the back of the knees.

Dr. Harkin recommends showering within two hours of checking to wash off any unattached ticks. Plus, he says it reduces the risk of Lyme disease “when done promptly.” Don’t forget to check your clothing and gear, as ticks can survive hours to days on clothes, he adds. Put your clothes in a hot dryer for more than 10 minutes, and be sure to check your four-legged family members for ticks, too.

How Do You Properly Remove and Dispose of a Tick?

Our experts all recommend one essential tool to remove a tick: tweezers. “You want to grab the embedded mouth parts as close to the skin as possible with needle-nosed or fine-tipped tweezers,” says Dr. Long. “Grasp the mouthparts firmly with the tweezers and pull directly away from the skin at a 90-degree angle.” Don’t apply petroleum jelly, nail polish, fire, or other substances in an attempt to encourage the tick to let go, as this can only make the situation worse.

To dispose of a tick, “place it in alcohol, a sealed bag [or] container, or flush it down the toilet,” says Harkin. “You may save it in a sealed container, with date and location noted, in case illness develops.”

Arnabolidi adds that “Some providers will provide tick identification if you wish, there are some local health agencies that will as well.” The CDC recommends against blanket testing prior to developing symptoms as negative results can lead to a false sense of security.

What Diseases Are Transmitted by Ticks?

There are a variety of tick-borne illnesses in the United States:

“Different ticks tend to carry different infections, and incubation times can vary from a few days to weeks,” says Long. Lyme disease is “the most common vector-transmitted disease in North America, and is caused by the bacterium Borrelia burgdorferi,” adds Arnaboldi. “However, it is far from the only one. The same ticks that transmit Lyme disease also transmit other infectious agents.” Those ticks, also known as “blacklegged ticks” or “deer ticks,” can cause other diseases, including anaplasmosis, relapsing fever, ehrlichiosis, babesiosis, and Powassan virus disease.

There’s also the Lone Star tick, which has a white spot on its back and transmits Ehrlichia chafeensis.

“This causes ehrlichiosis, an infection similar to anaplasmosis that infects white blood cells called monocytes,” says Harkin, adding that this tick is also associated with causing a red meat allergy (alpha-gal syndrome).

FAQ

What should you do after removing a tick?

First, wash the bite with soap and water. Arnaboldi recommends flushing the tick down the toilet. “If you plan to retain the tick for identification, place it in a container with rubbing alcohol,” he adds. “Whatever you do, keep it sealed. Hard-bodied ticks do not die easily, and you do not want it to escape.” Lastly, keep an eye on the area for the next week or so for any signs of infection.

What are the symptoms of a tick bite?

You’ll likely notice the tick attached to your skin first, “sometimes with pain and itching at the bite where the tick is still attached,” says Long. It may not be noticeable at first, so it’s important to check for ticks periodically, especially if you’ve been in an area where ticks are more present, he adds.

What month are ticks the worst in?

Unfortunately, ticks are out for several months each year. “The greatest risk of blacklegged tick bites exists in spring, summer, and fall in the Northeast, Upper Midwest, and mid-Atlantic regions, though adult ticks may be active any time winter temperatures are above freezing,” says Harkin.

Why Trust Everyday Health

We independently investigate and recommend products and services we believe will enrich the lives of our readers and meet their specific needs. You can trust our reviews because we do the legwork for you. Read more about why you can trust us.

Katrina Cossey

Author

Katrina Cossey is a writer and editor with over 10 years of experience in broadcast and service journalism. Over her career, she’s covered topics such as the COVID-19 pandemic, new...

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Medical Reviewer

Ross Radusky, MD, is a practicing board-certified dermatologist at the Dermatology Treatment and Research Center in Dallas. Originally from New York City, he graduated summa cum la...

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Alexandra Klausner is a freelance health writer and editor with over 10 years of journalism experience. Prior to going freelance, she worked as a reporter and editor at the New Yor...

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Jen Sinclair Is a freelance health and wellness writer who has spent the last two years writing feature articles and reviews of mental health and medical services and products. Her...

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Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.

Resources

Tickborne Disease Surveillance Data Summary. Centers for Disease Control and Prevention. July 15, 2024.
Eisen L. Efficacy of Unregulated Minimum Risk Products to Kill and Repel Ticks. Emerging Infectious Diseases. January 2024.
Is DEET Bad for You? Cleveland Clinic. June 26, 2023.
Carr AL, et al. Ticks home in on body heat: A new understanding of Haller’s organ and repellent action. PLOS ONE. August 2019.
DEET. United States Environmental Protection Agency. May 20, 2026.
Gliniewicz A, et al. Susceptibility of Dermacentor reticulatus tick to repellents containing different active ingrediens. Przeglad Epidemiologiczny. 2019.
DEET Technical Fact Sheet. National Pesticide Information Center.
Skin-Applied Repellent Ingredients. United States Environmental Protection Agency. January 23, 2026.
Picaridin Technical Fact Sheet. National Pesticide Information Center.
Shiau A, et al. Characterization in Effective Stimulation on the Magnitude, Gating, Frequency Dependence, and Hysteresis of INa Exerted by Picaridin (or Icaridin), a Known Insect Repellent. International Journal of Molecular Sciences. August 2022.
Toxicological Profile for DEET (N,N-diethyl-meta-toluamide). Centers for Disease Control and Prevention. May 28, 2020.
Efficacy of Unregulated Minimum Risk Products to Kill and Repel Ticks. Centers for Disease Control and Prevention. January 2024.
Sullivan KM, et al. Bioabsorption and effectiveness of long-lasting permethrin-treated uniforms over three months among North Carolina outdoor workers. Parasites & Vectors. January 2019.
What to Do After a Tick Bite. Centers for Disease Control and Prevention. July 15, 2025.
Tick Bites. Cleveland Clinic. June 5, 2026.
Ice Packs vs. Warm Compresses For Pain. Johns Hopkins Medicine.
Calamine Lotion. Cleveland Clinic. June 24, 2022.
Bites and Stings: Insects. Johns Hopkins Medicine.
Antihistamines. Cleveland Clinic. July 26, 2024.
Hydrocortisone (topical application route). Mayo Clinic.
Pet-friendly mosquito repellents (that humans can use too). Animal Humane Society.
Sutton NM, et al. Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons Information Service (VPIS), London. Journal of Feline Medicine and Surgery. January 2017.
Checking for ticks. U.S. Department of Agriculture Forest Service.
About Ehrlichiosis. Centers for Disease Control and Prevention. May 15, 2024.

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Bite Relief You’ll Always Want On Hand

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Relieve the Itch

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Tackle Multiple Symptoms

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How Can You Prevent Tick Bites?

How Do You Check for Ticks?

How Do You Properly Remove and Dispose of a Tick?

What Diseases Are Transmitted by Ticks?

FAQ

Why Trust Everyday Health

Katrina Cossey

Author

Ross Radusky, MD

Medical Reviewer

Orlando de Guzman

Fact-Checker

Olivia Campbell

Editor

Alexandra Klausner

Tester

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Olivia Campbell

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