Genital Herpes Treatment: Medication, Lifestyle Changes, and More 

Genital Herpes Treatment: Medication, Lifestyle Changes, and More

Genital Herpes Treatment: Medication, Lifestyle Changes, and More
Everyday Health

Genital herpes is a lifelong infection caused by herpes simplex virus type 1 or type 2 (HSV-1 or HSV-2), both of which may be spread through sexual contact. There’s no cure, but antiviral medications can help people manage their symptoms and lower the risk of passing the virus to others.

Not everyone with genital herpes chooses to take medication, but most people who have symptoms can benefit from it. Talk to your doctor to discuss which treatment approach works best for you.

“Herpes can be managed, with a person being able to lead a normal life and without the impact that people are often afraid of,” says H. Hunter Handsfield, MD, a professor emeritus at the University of Washington Center for AIDS and STD in Seattle.

Medication

If you are infected with genital herpes, your doctor may prescribe oral antiviral drugs to help ease your symptoms during a first outbreak and recurring ones. Even if your first episode of herpes is mild, you may have severe or prolonged symptoms later. For this reason, the Centers for Disease Control and Prevention recommends that everyone who has a first episode of genital herpes take antiviral drugs.

Three antiviral drugs, all taken by mouth, are used to treat most cases of genital herpes:

  • valacyclovir (Valtrex)
  • acyclovir (generic)
  • famciclovir (generic)
In October 2026, a new antiviral called pritelivir (Hovilpri) was approved by the U.S. Food and Drug Administration (FDA) for treating genital herpes in immunocompromised adults whose infection hasn’t responded to the three standard medications above. It’s not a first-line option for most people, but it is a new tool for cases that are harder to treat.

Antiviral drugs do not wipe out the virus completely. It continues to live in your body, so if you stop taking the drugs, you may have more frequent outbreaks or more intense symptoms, and you may be more likely to transmit the virus to others.

Taking Daily Oral Pills to Reduce Herpes Outbreaks

Some people with genital herpes take antiviral medication daily, called suppressive therapy, to have fewer outbreaks. For people who have frequent outbreaks, suppressive therapy reduces them by 70 to 80 percent, and many people taking it report having no outbreaks at all.

Research has shown that acyclovir, famciclovir, and valacyclovir, the three standard antivirals for genital herpes, are safe and effective for long-term daily use. In one study, daily valacyclovir treatment lowered the risk of HSV-2 transmission in heterosexual couples in which one partner has a history of HSV-2 infection.

Suppressive therapy is also likely to reduce transmission for people who have multiple sex partners.

Lifestyle Changes

Many people with genital herpes worry most about passing the virus to a partner, says Dr. Handsfield. Herpes spreads through skin-to-skin contact, and it can pass to a partner even when no symptoms are present. This is called asymptomatic shedding, and it’s most common in the first year after infection.

The main ways to lower the risk of transmission include:

  • Learn to recognize the first warning signs of an outbreak, such as itching or tingling, and avoid having sex immediately.
  • Use condoms consistently to reduce the risk of spread.
  • Avoid touching the sores. If you do, wash your hands right away to avoid spreading the virus to other parts of your body.
  • Avoid kissing and oral sex when you have a cold sore, because HSV-1 can spread from the mouth to the genitals.
  • Tell potential partners about your infection before having sex, even though the conversation may be difficult.
  • Ask your doctor about taking daily suppressive therapy, which can lower the risk of transmission.

Complementary and Integrative Approaches

Managing stress may help reduce herpes outbreaks, since stress is a common trigger.

Getting enough sleep and eating a nutritious diet can also support a healthy immune system and make stress easier to handle.
Some supplements and topical creams have shown promise in small studies. These include lysine, an amino acid, and propolis, a resinlike substance made by honeybees. Small studies have shown that using a propolis ointment combined with acyclovir may better suppress herpes recurrences than using acyclovir alone.

However, evidence for these products is limited, and none has been proven as effective as antiviral medication. Talk to your doctor before trying a supplement, since some can cause side effects or interact with other medications.

Mental Health

A genital herpes diagnosis can take an emotional toll, but understanding the condition can help. “Herpes has a tremendous psychosocial overlay. But knowledge about it and understanding about how well it can be managed can reduce that,” says Handsfield.

Your doctor can answer many of your questions. Counseling from a mental health professional or a sexual health clinic, such as Planned Parenthood, can also help. If you have a regular partner, including them in these conversations gives them a chance to learn about herpes and ask their own questions.

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. STI Treatment Guidelines, 2021: Genital Herpes. Centers for Disease Control and Prevention. September 21, 2022.
  2. FDA Approves Drug to Treat Lesions Caused by Herpes Simplex Virus. U.S. Food and Drug Administration. October 9, 2026.
  3. Vorvick LJ. Genital herpes. MedlinePlus. July 3, 2025.
  4. Chang JY et al. A Narrative Review of Alternative Symptomatic Treatments for Herpes Simplex Virus. Viruses. June 2, 2023.
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Kara Smythe, MD

Medical Reviewer

Kara Smythe, MD, has been working in sexual and reproductive health for over 10 years. Dr. Smythe is a board-certified fellow of the American College of Obstetricians and Gynecolog...

Milly Dawson

Author

With decades of experience serving organizations and media outlets that promote health, Milly Dawson brings passion, energy, and precision to conveying ideas with accuracy, eleganc...