Is It Safe to Take Calcium Supplements? 6 Risks You Should Know

Note: The U.S. Food and Drug Administration (FDA) does not approve supplements for safety or effectiveness. Talk to a healthcare professional about whether a supplement is the right fit for your individual health, and about any potential drug interactions or safety concerns.
If you’re concerned you’re not getting enough calcium, you may be considering supplements. There’s no doubt that calcium is essential for strong teeth and bones — and has long been considered a key supplement for preventing bone loss in women — but the way you ingest it matters.
Getting enough calcium from food, rather than supplements, is generally recommended for most people. Calcium supplements may even pose health risks, especially in older adults and women postmenopause.
Beyond these groups, calcium supplements can cause a range of side effects worth knowing about before you start taking them.
1. May Reduce Nutrient Absorption
If you choose to use calcium in addition to other vitamin and mineral supplements, Dr. Stephenson recommends staggering your intake of each by several hours. This helps ensure that your body is able to absorb each nutrient efficiently.
Calcium supplements also lack the additional nutrients you get when eating calcium-rich foods. “Calcium-rich foods often contain vitamin K, vitamin D, and magnesium. These nutrients help maximize your calcium intake,” says Yoon Hang Kim, MD, MPH, a board-certified preventive medicine physician and integrative functional medicine practitioner in San Antonio, Texas.
2. May Cause Constipation
Unlike food, which contains small, manageable amounts of calcium, supplements slow down the passage of food through the digestive tract. This can cause gastrointestinal (GI) issues like constipation, gas, and bloating.
If you take calcium supplements, dividing your daily dose into smaller increments may reduce this effect. “The body absorbs calcium most efficiently when calcium supplements are taken in small doses, rather than in one large, daily amount,” explains Shaye Arluk, RDN, a registered dietitian-nutritionist and nutrition and wellness coordinator with Sentara Brock Cancer in Norfolk, Virginia.
3. May Lead to Hypercalcemia
4. May Interact With Medications
- Thyroid medications like levothyroxine
- Antibiotics used to treat bacterial infections
- Human immunodeficiency virus (HIV) treatments like dolutegravir
It’s best to consult your healthcare provider before starting calcium supplementation if you take medications, Arluk says.
5. May Raise the Risk of Kidney Stones
6. May Increase Heart Disease Risk
“Most people can take calcium supplements safely, in moderation,” Dr. Kim says. But he recommends turning to calcium-rich foods instead of supplements if you have a personal or family history of heart disease.
Who Still Might Need Calcium Supplements?
“The only population I ever recommend focusing on supplements are those with a true lactose intolerance or dairy allergy, who cannot get the recommended dietary intake from food alone,” she adds.
If you’re worried that you’re not getting enough calcium from food, discuss your concerns with a healthcare provider. They can help you weigh the risks with the benefits of calcium supplements to determine if supplements are appropriate for you.
The Takeaway
- Calcium supplements can cause side effects, including constipation, reduced absorption of other minerals, and — when taken in excess — hypercalcemia, kidney stones, and may increase cardiovascular risk.
- Getting calcium from food is preferable to supplements for most people, as food sources provide additional nutrients like vitamin K, vitamin D, and magnesium that help the body use calcium effectively.
- Supplements may be appropriate for people with lactose intolerance or dairy allergies who can't meet their calcium needs through diet. But anyone considering them should consult a healthcare provider first.
- Reid IR. Calcium Supplementation - Efficacy and Safety. Current Osteoporosis Reports. February 12, 2025.
- Nutrition and Healthy Eating. Mayo Clinic. October 10, 2025.
- Definitions of Health Terms: Minerals: MedlinePlus. MedlinePlus. March 2, 2022.
- Calcium. National Institutes of Health Office of Dietary Supplements. July 11, 2025.
- Hypercalcemia. Mayo Clinic. March 8, 2024.
- Sadiq NM et al. Hypercalcemia. StatPearls. May 7, 2024.
- Kidney Stones. Cleveland Clinic. February 26, 2024.
- Calcium Kidney Stones. National Kidney Foundation. September 2, 2025.
- Bargagli M et al. Calcium and Vitamin D Supplementation and Their Association with Kidney Stone Disease: A Narrative Review. Nutrients. December 4, 2021.
- Myung SK et al. Calcium Supplements and Risk of Cardiovascular Disease: A Meta-Analysis of Clinical Trials. Nutrients. January 26, 2021.
- Kopecky SL et al. Lack of Evidence Linking Calcium With or Without Vitamin D Supplementation to Cardiovascular Disease in Generally Healthy Adults: A Clinical Guideline From the National Osteoporosis Foundation and the American Society for Preventive Cardiology. Annals of Internal Medicine. October 25, 2016.

Justin Laube, MD
Medical Reviewer
Justin Laube, MD, is a dual board-certified integrative and internal medicine physician, retreat leader, and healing educator with over 15 years of experience caring for patients w...

Corey Whelan
Author
Corey Whelan is a health, science, and tech writer, and CEO of Corey Whelan Writers LLC.
Throughout her career, Whelan has contributed thousands of articles, e-books, podcasts, and ...