These Are the 11 Best Methylated Multivitamins to Help Boost Your Health

We love that these multivitamins are gluten-free, made without genetically modified organisms (GMOs), and are certified by Consumer Lab, an independent, third-party company.

Sticking to a supplement routine can be a challenge, especially if you’re already taking other medications on a daily basis. Pure Encapsulations O.N.E. Multivitamin makes it easy to add a multivitamin to your routine, though, because all you have to do is take one capsule daily.

This multivitamin doesn’t contain iron, so if you’re deficient, you’ll need to add an iron supplement. Note, however, that it’s common for multivitamins to leave iron out of their formulation, since it can sometimes cause unwanted side effects, like constipation. Additionally, most people get enough iron from their diet, so you shouldn’t supplement unless you have a known deficiency. 

Swallowing pills isn’t for everyone. If a gummy vitamin is more your speed, Nordic Naturals Women’s Multivitamin Gummy is our top pick. This multivitamin doesn’t have as many vitamins and minerals as some of the others on our list, but it does contain the recommended RDA for methylated vitamin B12.

While it does contain folic acid, it’s not the methylated form. Because this vitamin contains fewer vitamins and minerals than others on this list, it could be a good option for those with very specific vitamin and nutrient needs.

Nordic Naturals prides itself on purity, integrity, and transparency, so every Nordic Naturals product is tested to verify potency, purity, and freshness by certified laboratories, although the laboratories are not listed on its website. Customers can enter the lot number of their product on the Nordic Naturals website to see the certificate of analysis.

This multivitamin doesn’t skimp on quality. It’s free of common allergens, Non-GMO Project verified, and tested by Consumer Lab. This supplement contains methylated vitamin B12 (10 mcg) but not the methylated form of B9.

Multivitamins our team would recommend to men are products that have added antioxidants known to support prostate and heart health. Pure Encapsulations Men’s Nutrients is a multivitamin that contains methylated forms of vitamins B12 and B9 as well as the full profile of other vitamins (vitamins C, A, D, E, K, and B vitamins) and a wide variety of minerals.

The other supplement packs are tailored to the unique needs of each trimester. Every pack contains ingredients in their most bioavailable form. For example, cholecalciferol is included (vitamin D3) instead of ergocalciferol vitamin D2, including methylated vitamin B12 and folate (amounts vary to meet the RDA of each pregnancy stage).

Each pack includes five pills, both softgels and capsules. Perelel’s products are third-party tested (labs are not disclosed on its website) and made in a certified facility that uses current good manufacturing practices (CGMP).

These supplements are a bit pricier than other prenatal multivitamins, but they’re eligible to buy with a health savings account (HSA) or flexible spending account (FSA), which can make them a bit more accessible.

Many subscription options are available when it comes to supplements, but Ritual is our favorite because of the quality and variety of products offered. Ritual makes multivitamins with methylated ingredients (vitamin B12 and B9) for women over 18 years old, women over 50, men over 18, and male and female teens.

Ritual Essential for Women Multivitamin 18+ features nine ingredients: methylated B9 and B12, iron, vitamin D3, vitamin K2, omega-3 DHA, boron, vitamin E, and magnesium — all of which can be traced back to their supplier and final place of manufacturing. Ritual takes a “less is more approach” when creating its supplements. This multivitamin contains fewer ingredients than other products on this list, and instead focuses on where certain groups of individuals more commonly have gaps in their diet.

“Too much of anything isn’t a good thing,” says Isabel Smith, RD, owner of Isabel Smith Nutrition and Lifestyle in New York City. We love that this supplement contains methylated vitamin B12 and B9 plus magnesium, a mineral that supports methylation.

According to its website, Ritual uses third-party labs, including Eurorfins and IEH Laboratories, to test for heavy metals and allergens, and its products are non-GMO verified. Compared with other subscription multivitamins, Ritual is more affordable at $33 per month.

If you have trouble with capsules or tablets, a liquid multivitamin, like MaryRuth’s Liquid Morning Multivitamin, is a great alternative. We like this option because it provides a full spectrum of vitamins and minerals, including methylated B12 and B9, as well as vitamins A, C, D, and E. It also contains trace minerals and amino acids.

Like dozens of other MaryRuth supplements, this multivitamin is Clean Label Project certified for purity. It’s made in a good manufacturing practices (GMP) facility and is tested for heavy metals. You can find the test results directly on MaryRuth’s website.

Unlike other vitamins on our list, this one needs to be refrigerated after opening. It’s also a bit pricier per serving than many tablets and capsules. However, we think the purity justifies the higher price, particularly if you’re interested in a liquid multivitamin.

If you’re looking for a multivitamin that prioritizes vitamin B12, we recommend Ancient Nutrition Women’s Once Daily, which contains methylated B12 and methylated folate.

I take this vitamin because I have two variants of the MTHFR mutation and don’t convert synthetic folic acid the way someone without the mutations does. I also have low vitamin D levels and wanted something with both vitamin D3 and vitamin K2 to support absorption, which this vitamin has.

I’ve been taking it for close to five months. As someone with a sensitive stomach, I haven’t noticed any gastrointestinal (GI) or other side effects. However, the capsules contain bovine liver and other animal-derived ingredients, so they’re not vegan- or vegetarian-friendly.

Seed’s DM-02 Daily Multivitamin is formulated to address your gut health while also filling any nutrient gaps. It uses a proprietary capsule-in-capsule delivery system: The outer capsule delivers vitamins and minerals to your upper GI tract, while the inner capsule delivers prebiotic compounds to the colon to support your gut microbiome.

While we feel comfortable recommending this vitamin for gut health, Seed encourages buyers to pair it with its DS-01 Daily Synbiotic (probiotics plus prebiotics) for additional benefits, as the DM-02 Multivitamin alone does not contain any live probiotics.