4 Expert Ways to Fight ‘Depression Fatigue’

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How to Manage Major Depressive Disorder–Related Fatigue
If you have depression, you’ve probably experienced feeling so sluggish that even tiny tasks like washing your face seem insurmountable. This feeling — commonly known as “depression fatigue” — is more than mere tiredness.
“It is not the same feeling you get when you’re sleepy and need to go to bed, but more so a physical sense of having no energy in your body,” says Michele Goldman, PsyD, a clinical psychologist in New York City and a media adviser for Hope for Depression Research Foundation.
What’s more, this type of fatigue worsens a key symptom of depression, making you get even less pleasure from activities you used to love. “The fact that you may not be enjoying the things that previously brought you joy or provided respite, and you may be struggling to complete daily tasks — all of that compounded can be very debilitating,” says Andrew Davis, MD, a psychiatrist and the assistant chief for behavioral health at Kaiser Permanente in Baltimore.
Why Does Depression Make You Fatigued?
Brain Chemistry
In particular, “depression impacts the neurotransmitters associated with the reward system and the system that regulates alertness,” says Dr. Goldman.
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Stress
Sleep Problems
Depression Medications
How to Fight Fatigue if You Have Depression
Fortunately, there are ways to minimize depression fatigue, which in turn can help you feel better over time. Here are four worth knowing about.
1. Exercise Most Days of the Week (Even Just a Little Bit Counts)
Exercise might be the last thing you feel like doing if you’re encumbered by fatigue. But regular exercise actually boosts your energy and helps you feel less exhausted over time, says Goldman.
“Exercise helps minimize fatigue, increases sleep drive or desire to sleep, and naturally increases [feel-good] neurotransmitters in the brain, including dopamine and serotonin, while also resulting in a natural energy boost,” Goldman says.
2. Stick to the Same Bedtime Routine Every Night
- Eat dinner earlier. Having a heavy meal late at night kicks your digestive system into high gear, which can delay your ability to fall asleep. Eating at least three hours before bed can help you sleep better.
- Avoid caffeine and alcohol in the afternoon and evening. Caffeine is a stimulant that worsens insomnia, and while alcohol may initially make you drowsy, it can trigger awakenings in the middle of the night.
- Go to sleep and wake up at the same time every day, including on weekends. A consistent pattern helps maintain your body’s circadian rhythm, the timing of its internal clock.
- Keep your bedroom quiet and dark. Noise and light can make falling asleep harder and cause frequent awakenings during the night. Donning an eye mask, hanging blackout curtains and using a white noise machine or even a fan can help.
- Keep your bedroom cool. The ideal temperature for sleep is about 65 to 68 degrees F, but this may vary from person to person.
- Shut off electronics 30 minutes to an hour before bed and stash your cell phone and laptop in another room. Seeing blue light emanating from screens, scrolling through social media, and checking email can all “turn on” your brain, delaying the transition to sleep.
If these strategies don’t help, reach out to your doctor and tell them you’re having trouble sleeping. They can help you figure out the cause, as well as recommend potential treatments for your sleep issues if needed.
3. Do Your Best to De-Stress
- Exercise. Along with boosting energy and lessening fatigue, exercise also causes your brain to release good-for-you chemicals that help keep you calm.
- Eat a nutritious diet. Nutrient-rich foods like fruits, vegetables, and whole grains improve both your physical and mental health.
- Consider yoga. Yoga’s poses, stretches, and controlled breathing exercises help your whole body relax.
- Meditate. Sitting still while you focus your attention on your breathing or visualize a calming space helps shift your mind to a tranquil space and encourages deep relaxation.
- Lean on loved ones for support. Staying connected with close family and friends and reaching out to them for support can help during worrying or frustrating times.
- Practice in-the-moment relaxation techniques, such progressive muscle relaxation. This involves breathing in as you tense the muscles in each area of your body — from your head to your toes — for 15 seconds, and then breathing out as you relax those muscles. Tensing and relaxing can relieve tension held in the body, which helps calm the mind.
- Take breaks. If a particular task is proving to be stressful, stepping away for a few minutes can lessen whatever tension or worry you’re feeling in that moment.
- Keep a journal. Recording your thoughts in writing or by drawing, whether it’s on paper, in your cell phone, or on your computer, can release negative feelings before they become bottled up inside you.
4. Tell Your Doctor if You’re Struggling With Fatigue
If exhaustion interferes with your ability to go about your day, reach out to your doctor or therapist. This is especially important if the fatigue is not relenting, if it’s worsening, or if other symptoms of depression start to worsen, Goldman says.
- Anemia
- Anxiety disorders
- Myalgic encephalomyelitis/chronic fatigue syndrome
- Diabetes
- Fibromyalgia
- Heart disease
- Hypothyroidism
- Lupus
- Multiple sclerosis
- Postural orthostatic tachycardia syndrome (POTS)
- Pregnancy
It’s important to note that having fatigue does not necessarily mean that you have one of these conditions — or that fatigue is not connected to other conditions.
Resources We Trust
- Cleveland Clinic: Depression
- Mayo Clinic: Depression (Major Depressive Disorder)
- A Mission for Michael: How to Manage Depression Fatigue: Coping Skills and Strategies
- Project Sleep: Sleepiness, Fatigue, or Depression? How to Tell the Difference
- Kaiser Permanente: Psychiatrist’s Top Tips for Combatting Depression Fatigue
- Fatigue. Cleveland Clinic. April 13, 2023.
- Will Depression Make You Tired? National Depression Hotline.
- Chen LH et al. Editorial: The Bio-Psycho-Social Approach to Understanding Mental Disorders. Frontiers in Psychology. June 13, 2023.
- How Depression Affects the Brain. Yale Medicine. June 17, 2021.
- Dopamine Deficiency. Cleveland Clinic. March 23, 2022.
- Depression and Sleep: Understanding the Connection. Johns Hopkins Medicine.
- Stress and Your Health. MedlinePlus. May 4, 2024.
- Antidepressants: Get Tips to Cope With Side Effects. Hancock Health.
- About Sleep. Centers for Disease Control and Prevention. May 15, 2024.
- American Heart Association Recommendations for Physical Activity in Adults and Kids. American Heart Association. January 19, 2024.
- Self-Help Tips to Fight Tiredness. NHS. November 8, 2023.
- Solodar J. Sleep Hygiene: Simple Practices for Better Rest. Harvard Health Publishing. January 31, 2025.
- Stress Relievers: Tips to Tame Stress. Mayo Clinic. August 3, 2023.
- Quick Stress-Relief Techniques for Busy Days. Kaiser Permanente. February 17, 2025.

Allison Young, MD
Medical Reviewer
Allison Young, MD, is a board-certified psychiatrist providing services via telehealth throughout New York and Florida.
In addition to her private practice, Dr. Young serves as an a...

Julia Métraux
Author
Julia Métraux is a journalist whose work touches on disability, mental health, and chronic illness. She went to the University of California in Berkeley Graduate School of Journali...