Exercises to Reduce Mantle Cell Lymphoma Fatigue

Exercises to Help Reduce Mantle Cell Lymphoma Fatigue

Exercises to Help Reduce Mantle Cell Lymphoma Fatigue
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Fatigue is one of the most common symptoms of mantle cell lymphoma (MCL), and it can affect nearly every part of daily life.

 Unlike the tiredness you feel after a long day, this type of fatigue does not improve with rest — it’s an ongoing exhaustion that makes everyday things like working, socializing, or even making a meal feel difficult.

While it may seem counterintuitive, exercise is one of the most effective ways to reduce cancer-related fatigue.

 And you don’t need long or intense workouts to feel a difference. Even a few minutes of physical activity can help you feel better throughout the day.

Types of Exercise for MCL Fatigue

Some types of exercise may be easier — or more accessible — than others. In general, though, you may want to opt for light to moderate physical activity, depending on your goals, interests, and abilities.

1. Walking

Walking is one of the easiest ways to begin an exercise routine. “[You] can begin by simply walking in [your] hallway, walking through store aisles, or parking further away from an entrance,” says Katarzyna Ibanez, MD, a rehabilitation medicine specialist at Memorial Sloan Kettering Cancer Center in New York City. Just 10 minutes a day can help you feel more energized.

And you don’t need prior experience with exercise to feel improvements. Research shows that walking reduces fatigue even for those who were not active before their diagnosis.

2. Yoga

Yoga is a gentle form of exercise that combines slow movements with focused breathing, which helps relax your body and mind.

 Regular practice can build strength, reduce muscle stiffness, and improve your balance.

Yoga can also improve your emotional health by reducing stress and feelings of anxiety or depression.

 When your mind feels calmer, sleep often improves, which can leave you with more energy the next day.

3. Light Strength Training

Strength training is any exercise that uses resistance to help your muscles stay strong — and it’s important because cancer and its treatments can lead to muscle loss over time.

When your muscles weaken, fatigue can get worse and make daily tasks harder than they need to be.

You don't need a gym, special equipment, or a tough workout to see results. Light hand weights, resistance bands, or even your own body weight can do the job.

 “Simple movements, like sitting down and standing up from a chair, are enough to help maintain strength,” says Michael Carrier, a physical therapist and the program manager of the health and wellness program at Dana Farber Cancer Institute.

How to Start an Exercise Routine

Here are a few things worth considering as you get ready to start a new workout routine.

Choosing Your Workout

When selecting an exercise plan, keep in mind that what works for someone else may not work for you, and that’s perfectly okay.

“No two patients are alike,” says Dr. Ibanez. “They all come with their unique background of prior health issues, comorbidities, past injuries, exercise behavior, cancer stage, and treatment experience.”

  • Personal Preferences Choose activities you enjoy and can stick with over time, whether that means walking outdoors, joining an online class, or exercising with a family member.
  • Cancer-Specific Factors Consider factors like your blood counts, heart health, and whether your cancer affects your bones or spleen. All of these may influence what activity is safe for you.
  • Other Health Conditions If you have another condition — such as arthritis, diabetes, or neuropathy — you may need to adjust your exercise plan to stay comfortable and prevent unnecessary pain.
  • Professional Guidance A physical therapist or certified cancer exercise specialist can help you build a plan tailored to your needs. Look for trainers with a Cancer Exercise Specialist certification.

Getting Started

Getting started may be easier than you think. "It doesn't mean joining a gym or hitting 30 minutes of exercise every day," says Carrier. "A few minutes of movement each day is enough to begin, and you can build at your own pace from there.”

  • Start small and build gradually. Begin with 5 to 10 minutes of movement each day, then add a few minutes as your stamina improves. If a longer session feels overwhelming, break it into two or three 10‑minute sessions throughout the day.

  • Prioritize consistency over intensity. Showing up regularly matters more than how hard your workout feels. Keep sessions short and matched to your fitness level.
  • Use the “talk test” to guide your pace. You should be able to talk comfortably while exercising. If you become breathless as you talk, slow your pace until it feels manageable.

  • Track your movement. A pedometer or phone app can help you see how much you move each day and keep you motivated.

Modifications

If you have certain health complications, you may need to adjust your exercise routine. Here are some modifications you can make to stay safe, based on which symptoms you may be experiencing.

  • Neuropathy Nerve damage can affect your balance and increase your risk of falling. Choose activities like a stationary bike or water exercise and use resistance machines rather than free weights for strength training.

  • Bone Involvement When your cancer affects the bones, your risk of fractures is higher. Avoid high-impact activities like running or jumping and opt for gentler options like swimming, using an elliptical machine, or doing light strength training.

  • Low Blood Cell Count When your red blood cell count is low, your heart has to work harder to move oxygen throughout your body. This can make you feel tired, weak, or short of breath. When your platelet count is low, you may also bruise or bleed more easily. Keep exercise light and avoid contact sports or heavy lifting. Hold off on activity if you feel dizzy or unwell, and check with your care team before you start again.

When to Push, When to Stop

Sticking to an exercise routine is important, even on days when your energy is low. On those days, try decreasing the amount of time you exercise or scale back on the intensity. That said, “not all fatigue is okay to push through,” says Carrier. “If minimal physical activity tanks you for the rest of the day and prevents you from doing basic daily tasks, it is not the time to push through.”

There are also times when you should stop exercising altogether. Stop right away and contact your care team if you have any of these symptoms during a workout.

  • Feeling out of breath
  • Dizziness, lightheadedness, or feeling faint
  • Extreme fatigue that does not improve within 60 minutes of finishing your workout
  • Racing or irregular heartbeat
  • Pain or pressure in your chest, arms, jaw, neck, shoulders, or back
  • New or worsening joint or muscle pain

Once your care team has evaluated your symptoms and given you the okay, you can slowly ease back into exercise.

Resources We Trust

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Fatigue (PDQ) — Patient Version. National Cancer Institute. November 6, 2024.
  2. Cancer-Related Fatigue. American Cancer Society. July 16, 2024.
  3. Bower JE et al. Management of Fatigue in Adult Survivors of Cancer: ASCO–Society for Integrative Oncology Guideline Update. Journal of Clinical Oncology. May 16, 2024.
  4. Exercising With Cancer. American College of Sports Medicine / Exercise Is Medicine.
  5. How Walking Can Help Reduce Cancer-Related Fatigue. American Cancer Society. April 9, 2026.
  6. Exercise and Lymphoma. Lymphoma Action. June 2025.
  7. Packel L. Aerobic Exercise Program During and After Cancer Treatment. OncoLink. December 31, 2025.
  8. Campbell KL et al. Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable. Medicine & Science in Sports & Exercise. November 2019.
  9. Cancer Related Fatigue and Exercise. Mayo Foundation for Medical Education and Research. 2015.
  10. Exercise During and After Cancer Treatment: Level 1. Memorial Sloan Kettering Cancer Center. October 30, 2025.
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Walter Tsang, MD

Medical Reviewer
Walter Tsang, MD, is a board-certified medical oncologist, hematologist, and lifestyle medicine specialist. Inspired by the ancient Eastern philosophy of yang sheng ("nourishing li...
Stephanie Ritz

Stephanie Ritz, PhD

Author

Stephanie Ritz, PhD, is a freelance medical writer specializing in oncology and rare diseases. With over a decade of experience as a research scientist and oncology consultant, she...