How to Manage Ovarian Cancer Fatigue

7 Ways to Manage Ovarian Cancer Fatigue and Maximize Your Energy

7 Ways to Manage Ovarian Cancer Fatigue and Maximize Your Energy
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Managing ovarian cancer often means finding a way to deal with a crushing tiredness that a good night’s sleep just won’t fix. Unfortunately, fatigue affects more than three-quarters of women with the disease.

“Fatigue is the most common symptom across all cancer patients, especially those with ovarian cancer,” says Gizelka David-West, MD, director of gynecologic oncology at Northwell Health in Mount Kisco, New York.
Fatigue can stem from the cancer and from its treatments. “The disease causes fatigue due to the ‘burden of disease,’ or the volume of cancer within the body and the physical toll it takes,” she says. “And more than 80 percent of individuals on active treatment describe fatigue as their No. 1 complaint.” Treatments such as chemotherapy, immunotherapy, and radiation can contribute to feeling low on energy or run down, usually starting within the first few weeks of treatment.

And the longer you’re dealing with ovarian cancer and treatment for it, the more that fatigue is exacerbated.

All of this can make living your life and enjoying the activities and people you love feel challenging. But there are strategies that can help. “The goal is to work around it, conserve energy, and utilize energy when it’s available,” says Dr. David-West.

1. Rule Out Other Factors That May Be Draining Your Energy

Things such as depression, excessive weight loss, inadequate nutrition, and poor sleep can all make fatigue worse. “Both a depressed mood and malnutrition can impact functional status and contribute to fatigue,” says Gina M. Mantia-Smaldone, MD, an associate professor of surgical oncology at Fox Chase Cancer Center in Philadelphia. And fatigue can lead to feelings of depression, so it can become a tricky cycle.

Depending on the symptoms you have, consulting with specialists such as a therapist or nutritionist can be helpful, says David-West. “A focus on a high-protein, low-sugar diet that minimizes processed foods is important to avoid sugar rushes and subsequent crashes,” she says, noting that good fats provide energy stores and can help mitigate nutrition-related fatigue.

If you cannot get a good night’s sleep, consider improving your sleep hygiene by going to bed and waking up at the same times each day, practicing relaxation techniques as part of your wind-down routine, and keeping your bedroom cool, dark, and quiet.

Also, be sure to discuss sleep challenges with your cancer care team.

2. Plan Around Your Treatment Cycle

When going through treatment, your energy levels can fluctuate from day to day. David-West recommends observing the first cycle to understand how your body responds, noting which days are especially difficult — for example, the first week after an infusion — and which leave you with higher energy levels. “Based on this, you can carve out a personalized schedule,” she says. For instance, wherever possible, avoid scheduling social events, multiple appointments, or big commitments at work when you anticipate feeling your worst. “This proactive time management helps you navigate treatment while maintaining your quality of life,” says David-West.

3. Lean On Friends and Family

On days when fatigue is at its worst, friends and family can provide emotional support, says Dr. Mantia-Smaldone. And don’t feel bad relying on family, friends, or neighbors for practical help. Chances are, they’ll be happy to pitch in with chores, meal prep, or everyday tasks that can be a struggle for you to complete when you’re low on energy.

4. Outsource Tasks That Zap Your Energy

If you don’t have family or friends who are close by and able to help, look into local chapters of organizations that could assist with meal delivery, groceries, and more. “Tapping into any available resource ultimately helps patients manage their energy,” says David-West.

Services such as Meals on Wheels America or the Food Is Medicine Coalition are two good options. Check if your health insurance offers assistance programs, too.

5. Incorporate Gentle Activity Into Your Day

Exercise is important for more than overall health. Research shows staying active may help improve fatigue, mood, and quality of life in people with ovarian cancer.

That said, “The key is to exercise when energy is present, not to push through profound fatigue,” says David-West. She recommends aerobic exercises, such as walking or swimming, and gentle activities, such as yoga, to stay active without overtaxing your body.

6. Don’t Fight the Fatigue

Staying active and focusing on quality sleep are powerful ways to manage fatigue, but it’s also important to accept that some fatigue is unavoidable. “Fatigue is multifactorial, meaning it’s influenced by factors beyond ovarian cancer itself, including emotions, sleep deprivation, anemia, psychological factors, and physical changes like decreased muscle mass and protein stores,” says David-West. Rather than fight it, acknowledge when it’s there, rest when you need to, and trust that the feeling will pass.

7. Discuss When Fatigue May Be a Red Flag

Tell your doctor about any fatigue that’s unrelenting, worsening, or not improving with rest, as this could be a sign that treatment isn’t working as expected or the cancer is progressing, says David-West.

You should also let your oncology team know if the fatigue is accompanied by dizziness, which could be a sign of worsening anemia, Mantia-Smaldone advises.

Any fatigue that’s accompanied by fever, nausea, or vomiting also warrants a call to your care team, Mantia-Smaldone adds. Depending on the cause, they may recommend adjusting the treatment dosage or taking a short treatment break. Or they may want to try adding on a treatment to address an underlying cause of fatigue, such as thyroid hormone replacement to treat an underactive thyroid. Fatigue with excessive sleepiness in the morning may be due to medication and is different from end-of-the-day fatigue. Be observant and tell your doctor about little things, as they can provide clues to fixing the fatigue.

At the end of the day, “It’s always important to keep an open dialogue with your [healthcare] provider,” emphasizes Mantia-Smaldone.

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Zhao J et al. Prevalence and Risk Factors for Cancer-Related Fatigue in Women With Malignant Gynecological Tumors: A Meta-Analysis and Systematic Review. BMC Cancer. May 5, 2025.
  2. Cancer-Related Fatigue. American Cancer Society. July 16, 2024.
  3. Healthy Sleep. MedlinePlus. December 9, 2025.
  4. McGrath D et al. Exercise Interventions for Women With Ovarian Cancer: A Realist Review. Healthcare. April 2022.

Tawee Tanvetyanon, MD, MPH

Medical Reviewer

Tawee Tanvetyanon, MD, MPH, is a professor of oncologic sciences and senior member at H. Lee Moffitt Cancer Center and Morsani College of Medicine at the University of South Florid...

Laurel Leicht

Laurel Leicht

Author

Laurel Leicht has been a writer and editor for nearly two decades. A graduate of the College of William and Mary and the master's program at the Missouri School of Journalism, she ...