What Is Ovulation?

Signs and Symptoms of Ovulation
- Mild pain in the abdomen or pelvis, or mittelschmerz
- Light vaginal bleeding or spotting
- Thin, clear, slippery discharge from the vagina
- Slight increase in resting (basal) body temperature
- Sore, swollen breasts
- Bloating
- Moodiness
- Increased sex drive
- Changes in appetite

Causes of Ovulation
For every cycle, eggs begin to develop in each of the follicles. Between the 10th and 14th day, one of the follicles will develop into a mature egg. Around the 14th day, LH levels surge and trigger ovulation.
How Is Ovulation Diagnosed?
Another way to tell is by looking for signs of ovulation, like changes in your cervical mucus or basal body temperature. During ovulation, vaginal discharge will become thin, clear, and slippery like egg whites, and your resting (basal) body temperature will rise slightly.
Treatment and Medication Options for Ovulation
Medication Options
- Clomiphene citrate (Clomid, Serophene) is a pill that stimulates the pituitary gland to release more FSH and LH, causing an egg to grow and be released.
- Letrozole (Femara) increases FSH levels to induce ovulation.
- Gonadotropins (Menopur, Gonal-F, Follistum) are stronger medications that trigger "superovulation," or the release of multiple eggs at once. These drugs can help people over 40 conceive by causing several egg follicles develop per cycle.
- Metformin triggers ovulation by improving insulin resistance, a common cause of infertility in women with polyendocrine metabolic ovarian syndrome (PMOS), formerly called polycystic ovary syndrome (PCOS).
- Bromocriptine (Cycloset, Parlodel) helps with ovulation problems caused by excess production of the hormone prolactin from the pituitary gland.
Complementary and Integrative Therapies
- Acupuncture
- Yoga
- Massage
- Meditation
- Herbal supplements
Prevention of Ovulation
Lifestyle Changes for Ovulation
The following lifestyle tips can also help improve fertility.
Note: Following a May 2026 global consensus, Polycystic Ovary Syndrome is now officially called Polyendocrine Metabolic Ovarian Syndrome (PMOS) to highlight the metabolic roots of the condition.
Maintain a Healthy Weight
Avoid Exposure to Harmful Substances
The following substances may alter your hormone levels in ways that disrupt ovulation:
- Smoking: Chemicals in tobacco smoke lower levels of estrogen and progesterone. This drop in hormones can cause a reduction in egg quantity and quality. Smoking also damages the DNA in eggs, increasing the risk for miscarriage and birth defects.
- Heavy alcohol use: Drinking more than one or two alcoholic beverages each day could affect ovulation. Abstention from alcohol is best when you’re trying to conceive.
- Caffeine: While one or two small (6- to 8-ounce) cups of coffee a day shouldn't affect your ability to get pregnant, drinking more than that may cause problems with ovulation and reproduction.
- Chemical exposure: Exposure to pesticides, heavy metals, dry cleaning chemicals, and other toxins in the environment and at work might have a negative effect on ovulation and fertility.
Exercise in Moderation
How Long Does Ovulation Last?
Related Conditions
- Hypothyroidism (underactive thyroid gland) or hyperthyroidism (overactive thyroid gland)
- PMOS
- Premature ovarian failure, which is when the ovaries stop working before age 40
- Too much prolactin, a hormone made by the pituitary gland that stimulates milk production after childbirth
FAQ
Resources We Trust
- Cleveland Clinic: Ovulation
- Mayo Clinic: What Ovulation Signs Can I Watch for if I Want to Get Pregnant?
- Office on Women's Health: Ovulation Calculator
- MedlinePlus: Ovulation Home Test
- Harvard Health: Mid-Menstrual Cycle Pain (Mittelschmerz)
- Ovulation. Cleveland Clinic. March 18, 2026.
- Q&A About Ovulation with a Reproductive Endocrinology and Infertility Specialist. Northwestern Medicine. August 2022.
- Ovulation signs: When is conception most likely? Mayo Clinic. July 9, 2024.
- JE Holesh et al. Physiology, Ovulation. StatPearls. May 1, 2023.
- Infertility. Mayo Clinic. September 13, 2023.
- Ovulation Induction. UCSF Center for Reproductive Health.
- Female Infertility. Mayo Clinic. August 27, 2021.
- Sehgal S et al. Integrative medicine utilization among infertility patients. Reproductive Biology and Endocrinology. August 2, 2023.
- Birth Control Options. Cleveland Clinic. May 28, 2026.
- Female Fertility: Why Lifestyle Choices Count. Mayo Clinic. January 9, 2024.
- Zheng L et al. Obesity and its impact on female reproductive health: unraveling the connections. Frontiers in Endocrinology. January 9, 2024.
- Weight, fertility, and pregnancy. Office on Women's Health. October 23, 2025.
- Dhage VD et al. A Narrative Review on the Impact of Smoking on Female Fertility. Cureus. April 16, 2024.
- Yaser Anwar M et al. The association between alcohol intake and fecundability during menstrual cycle phases. Human Reproduction. June 8, 2021.
- Jain M et al. Environmental Toxins and Infertility. StatPearls. January 19, 2025.
- Mussawar M et al. The effect of physical activity on fertility: a mini-review. F&S Reports. April 14, 2023.
- What Is Ovulation? Cleveland Clinic. March 18, 2026.
- Ovulation Pain. Cleveland Clinic. February 9, 2023.

John Paul McHugh, MD
Medical Reviewer
John Paul McHugh, MD, is an obstetrician-gynecologist and lifestyle medicine specialist in southern California. He has always placed wellness at the center of his work, in both del...
