16 Celebrities Who’ve Taken GLP-1 Weight Loss Drugs

American basketball legend Shaquille O’Neal shared in June 2026 that he takes Zepbound (tirzepatide) for obstructive sleep apnea (OSA), a condition that causes shallow or interrupted breathing while asleep.

“When my doctor told me I had moderate obstructive sleep apnea, it clicked — this wasn’t just about snoring, it was a real health condition. Being prescribed Zepbound helped make a difference for me in my OSA treatment journey; I even lost some weight.”

But she didn’t reveal one setback she’d had on her health journey. In a later interview with People, published in December 2025, Winfrey revealed that just six months after starting GLP-1s, she’d decided to see if she could “beat the medication” by stopping taking them. Her goal was to prove she could maintain the weight loss on her own.

“I knew my body was missing something it needed. For me, the answer was GLP-1s,” Williams said.

“I feel like I have a lot of energy and it’s great. I just feel pretty good about it,” said Williams.

Goldberg also discussed how all the constant chatter around people’s appearance can be harmful — and how everyone should be nicer to themselves and others. “Maybe the key is to stop judging everybody. Maybe that’s the key,” she said.

The former professional basketball star said he lost around 60 lb by taking Mounjaro, in addition to exercising and maintaining a healthy diet.

“It was hard work ... especially during the pandemic,” said Bates.

The actor also shared her plans to work out more, with activities like walking and Pilates, in order to maintain her weight loss.

The “All About That Bass” singer and her husband, actor Daryl Sabara, took the lowest drug dose and combined the medication with exercise and balanced meals in a weight loss journey made for two.

The Grammy winner took to social media to respond to people who kept commenting on her transformation after her appearance at Billboard’s 2025 Women in Music Awards.

“No, I don’t look like I did 10 years ago. I’ve been on a journey to be the healthiest, strongest version of myself for my kids and for me. I’ve worked with a dietitian, made huge lifestyle changes, started exercising with a trainer, and yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy. And I’m so glad I did because I feel great,” Trainor wrote on Instagram.

The 10-time Grand Slam winner spoke to actor Julia Louis-Dreyfus on the podcast Wiser Than Me about her decision to try a GLP-1.

“I’m a binge eater,” said the now 82-year-old King. “Every morning, I wake up, I tell myself I have an eating disorder. ... It’s interesting with the new injections, you know, with the Ozempics of the world. It’s very interesting because my doctor wants me to try it.”

Gaffigan is puzzled by the stigma around the medication, which is part of the reason he wanted to talk about it. “I don’t think there’s anything wrong with it. ... It’s just whatever gets you through,” he said.

The Tesla and SpaceX chief has said he wants to make the drug more accessible to all Americans, posting on X in 2024 that “nothing would do more to improve the health, lifespan, and quality of life for Americans” than making GLP-1s “super low cost to the public.”

Surprisingly, the comedian didn’t know she was taking Ozempic when she first received a prescription, she said in an interview on the Call Her Daddy podcast. “My anti-aging doctor just hands it out to anybody,” Handler said. “I didn’t even know I was on it.”