17 Celebrities Who’ve Taken GLP-1 Weight Loss Drugs

The fan-fave This Is Us actress was dubious about GLP-1s for years, assuming they wouldn’t work or unpleasant side effects would make the experience unbearable. But as she started perimenopause, she realized it may be time to give these meds a try.

Now a new brand ambassador for the digital health company Ro, Metz has replaced her GLP-1 skepticism with better health and a new relationship with food.

“It’s so nice not to be obsessing about what I’m going to have [to eat] every minute, even as I’m still consuming the meal,” she says. I vilified food for so long because I was taught that it was bad, and you shouldn’t eat this or that. And it’s been helping me be more mobile and have less joint pain and inflammation.”

American basketball legend Shaquille O’Neal shared in June 2026 that he takes Zepbound (tirzepatide) for obstructive sleep apnea (OSA), a condition that causes shallow or interrupted breathing while asleep.

“When my doctor told me I had moderate obstructive sleep apnea, it clicked — this wasn’t just about snoring, it was a real health condition. Being prescribed Zepbound helped make a difference for me in my OSA treatment journey; I even lost some weight.”

But she didn’t reveal one setback she’d had on her health journey. In a later interview with People, published in December 2025, Winfrey revealed that just six months after starting GLP-1s, she’d decided to see if she could “beat the medication” by stopping taking them. Her goal was to prove she could maintain the weight loss on her own.

“I knew my body was missing something it needed,” Williams said. “For me, the answer was GLP-1s.”

“I feel like I have a lot of energy and it’s great. I just feel pretty good about it,” said Williams.

“Everyone assumes losing the weight is the hard part,” Wilson said in the company’s press release. “Two kids and five years later, I can tell you staying there is the real test, and the one most people don't talk about. The habits I built with Noom are just part of my life now. That's the thing nobody tells you: When they actually stick, it stops feeling like a battle.”

Goldberg also discussed how all the constant chatter around people’s appearance can be harmful — and how everyone should be nicer to themselves and others. “Maybe the key is to stop judging everybody,” she said.

The former professional basketball star said he lost around 60 lb by taking Mounjaro, in addition to exercising and maintaining a healthy diet.

“It was hard work ... especially during the pandemic,” said Bates.

The actor also shared her plans to work out more, with activities like walking and Pilates, in order to maintain her weight loss.

When the “All About That Bass” singer and her husband, actor Daryl Sabara, started taking GLP-1 medications, they took the lowest drug dose and combined the medication with exercise and balanced meals. That approach worked, and the Grammy winner took to social media to respond to people who kept commenting on her transformation after her appearance at Billboard’s 2025 Women in Music Awards.

“No, I don’t look like I did 10 years ago. I’ve been on a journey to be the healthiest, strongest version of myself for my kids and for me. I’ve worked with a dietitian, made huge lifestyle changes, started exercising with a trainer, and yes, I used science and support (shoutout to Mounjaro!) to help me after my second pregnancy. And I’m so glad I did because I feel great,” Trainor wrote on Instagram.

The 12-time Grand Slam singles title winner spoke to actor Julia Louis-Dreyfus on the podcast Wiser Than Me about her decision to try a GLP-1.

“I’m a binge eater,” said the now 82-year-old King. “Every morning, I wake up, I tell myself I have an eating disorder. ... It’s interesting with the new injections, you know, with the Ozempics of the world. It’s very interesting because my doctor wants me to try it.”

Gaffigan also opened up in March 2026 to Craig Melvin’s podcast Glass Half Full that he still uses the medications — even though he doesn’t expect he’ll lose any more weight — because it helps tamp down his ravenous appetite.

The Tesla and SpaceX chief has said he wants to make the drug more accessible to all Americans, posting on X in 2024 that “nothing would do more to improve the health, lifespan, and quality of life for Americans” than making GLP-1s “super low cost to the public.”

Surprisingly, the comedian and former talk show host claimed she didn’t know she was taking Ozempic when she first received a prescription, she said in an interview on the Call Her Daddy podcast. “My anti-aging doctor just hands it out to anybody,” Handler said. “I didn’t even know I was on it.”

Three years later, in 2025, the actor reported that she was having “a really good experience” taking a different weight loss drug, Mounjaro, along with hormone replacement therapy for perimenopause symptoms. In November of that year, she also removed all of her pre-weight loss photos and posts from her Instagram account.