Treating Comorbid Insomnia and Sleep Apnea (COMISA)

How to Treat Sleep Apnea When You Have Insomnia, Too

How to Treat Sleep Apnea When You Have Insomnia, Too
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Comorbid insomnia and sleep apnea (COMISA) is the co-occurrence of both obstructive sleep apnea (OSA) and insomnia, two of the most common sleep disorders.

OSA happens when your throat muscles relax and block your airway, causing breathing to repeatedly start and stop during sleep. Meanwhile, insomnia is characterized by difficulty falling or staying asleep. Together, these conditions affect an estimated 18 and 42 percent of people worldwide, and are associated with an increased risk of heart issues.

How Each Condition Makes the Other Worse

OSA and insomnia don’t just happen to occur together — each condition actively makes the other harder to manage, creating a cycle that can be difficult to break.

People with insomnia often experience what scientists call hyperarousal — a state of constant nervous system alertness that makes it hard to fall and stay asleep.

 This reduces the time spent in slow wave sleep — the deepest sleep stage that protects against airway collapse by keeping the upper airway muscles toned and active. Less time in deep sleep means the airway is more vulnerable, and your brain is more likely to be triggered awake by breathing disruptions.

OSA compounds the problem from the other direction.

People with OSA experience repeated interruptions in breathing during the night. Often, they’re not aware of it. But the pauses in breathing trigger a spike in cortisol (a stress hormone) that can cause them to wake up.

 “As soon as you wake up because you’re not breathing, you can’t fall back asleep,” says Chafen Watkins Hart, MD, a pediatric sleep specialist with National Jewish Health in Denver, Colorado, who treats insomnia and OSA in patients of all ages.

Over time, your brain begins to resist sleep. “The brain goes, ‘Sleep is not fun. We don’t like sleep,’” Dr. Hart says.

The result is a self-reinforcing loop: OSA fragments sleep and triggers stress hormones that cause insomnia; insomnia reduces deep sleep, which leaves the airway more vulnerable to collapse, leading to more awakenings and more cortisol.

“The perpetuating factor that keeps insomnia from getting better is often apnea,” Hart says. “Unless we treat the sleep-disordered breathing, nothing we do for insomnia will work for very long.”

Why This Matters for Your Heart

Leaving COMISA untreated can have a negative impact on your heart.

Researchers followed nearly 100,000 U.S. veterans for 20 years and discovered that people with COMISA had more than double the risk of developing high blood pressure (hypertension), and triple the risk of cardiovascular disease compared with those without a sleep disorder.

The reason relates to how OSA and insomnia each independently affect the heart.

The prevalence of OSA, for example, is as high as 80 percent in people with high blood pressure, heart failure, coronary artery disease (CAD), and stroke.

 “When you have these interruptions in sleep, it increases intrathoracic pressure,” Hart says. “You get abnormal filling and pressure on the right side of the heart.”
Insomnia, meanwhile, is associated with a 45 percent increased risk of developing or dying from cardiovascular disease.

 When you pair OSA and insomnia, both conditions may stress the heart more than either condition alone.
To understand why, researchers analyzed more than 5,000 overnight heart rhythm recordings (electrocardiograms) from the Sleep Heart Health Study, a long-running U.S. population study. They found that the repeated breathing interruptions that occur with OSA during sleep disrupt the autonomic nervous system that controls heart rate, blood pressure, and the body’s stress response, creating a persistent imbalance that keeps the body’s fight-or-flight system activated when the calming, recovery system should take over.

Insomnia, meanwhile, significantly raises average heart rate during sleep — a sign that the nervous system hyperarousal that makes it hard to fall asleep in the first place doesn’t fully switch off once sleep begins. Together, having COMISA keeps the nervous system stuck in “stress mode” overnight, when the body should be recovering.

How to Treat Both Conditions at Once

Doctors used to treat sleep apnea first. "But then we found that we were just not successful — you just couldn't convince anyone to use a CPAP who is already struggling with sleep," Hart says. (CPAP is continuous airway pressure, a common treatment for sleep apnea.) Now it’s more common to address both conditions simultaneously.

That said, some people find more success by targeting one issue before tackling the other. The order and pace of treatment is highly individual — what works best depends on the severity of each condition and your own preferences. So, it’s best to discuss your treatment goals with your doctor.

Here are the standard approaches to addressing each condition.

CPAP for Your Sleep Apnea

The gold standard treatment for OSA is a CPAP machine. It delivers continuous air through a mask worn over either your nose and mouth or just your nose to keep your airways open while you sleep.

CPAP therapy significantly improves OSA, producing significant, lasting reductions in the apnea-hypopnea index (AHI), the number of breathing interruptions that occur per hour. In one study, people who used CPAP started with an average AHI of 49.2 events per hour — which qualifies as severe OSA — and ended within the normal range at 3.4.

Ideally, you’ll start CPAP at the same time as you treat your insomnia. But if your sleep apnea is the more urgent concern, for instance you wake up gasping, your doctor may be more aggressive about treating the apnea first, Hart says.

Still, you may see dramatic improvements in sleep by simply addressing OSA. "I've had patients for whom CPAP was a huge game changer in their insomnia,” Hart says. “They started it and within months had made strides."

Regardless of treatment timing, it’s important to give yourself time to adjust to CPAP therapy. For patients who struggle with discomfort with a CPAP mask, Katherine Belon, PhD, a licensed clinical psychologist with certifications in behavioral sleep medicine and cognitive behavioral therapy for insomnia with a private practice in Albuquerque, New Mexico, recommends wearing it for 20 to 30 minutes a day while watching TV or relaxing. Once you feel more comfortable, you can start incorporating your CPAP into your nightly routine.

CBTi for Your Insomnia

The recommended first-line treatment for insomnia is cognitive behavioral therapy for insomnia (CBTi), a structured therapy that involves changing your behaviors and habits around sleep.

 “That in and of itself is often a surprise, because people think insomnia is a medical condition and would be treated with medications,” Dr. Belon says. “But CBTi in the long run tends to do much better than sleep medications for insomnia."
Indeed, many common medications used to treat insomnia often suppress breathing, which can make OSA worse, Hart notes. CBTi, on the other hand, matches the effectiveness of sleep medications but has the advantage of no side effects.

CBTi also improves COMISA. In one study, people who completed a six-week CBTi program saw their AHI decrease by an average of 5.5 events per hour — a 15 percent improvement.

CBTi is led by a behavioral health provider, such as a psychologist or licensed therapist trained in sleep medicine. In addition to keeping tabs on your CPAP use, your CBTi provider will lead you through common strategies to improve insomnia, including:

  • Stimulus Control This trains your brain to associate your bed with sleep rather than wakefulness or anxiety. If you’re lying awake for more than 15 to 20 minutes, your therapist will encourage you to get up. “I also like to send a message that anytime you’re experiencing really strong negative emotions in bed — feeling frustrated, anxious, or panicky — that is also a cue to get out of bed,” Belon says.
  • Sleep Restriction This limits the amount of time you spend in bed to try to make you sleepier. “Your sleep drive is similar to hunger — it builds up the longer you go without sleep,” Belon explains. “If you take a nap, it’s like having a snack right before dinner. It’s going to weaken that appetite or sleep drive.” Your therapist will set a specific bedtime and wake time, often pushing your bedtime later than usual to strengthen that drive before gradually adjusting the window as your sleep improves.
  • Sleep Education Your therapist will address common myths and misconceptions about sleep, such as the popular advice to do something boring when you can’t sleep. That approach usually backfires, as it leaves your mind free to worry about sleep, Belon says. “You’re better off doing something that takes your mind off the fact that you can’t sleep, and waiting until you feel nice and sleepy as your cue to get back into bed.”
  • Cognitive Therapy This component targets the anxious thoughts and beliefs about sleep that develop over time and keep insomnia going. “Decreasing anxiety around insomnia is the biggest goal,” Belon says.

It typically takes four to eight sessions for CBTi to address insomnia. But people with COMISA may need more time, Belon says.

The Takeaway

  • COMISA is comorbid insomnia and sleep apnea, a condition that affects an estimated 18 and 42 percent of people worldwide.
  • When they happen together, insomnia and obstructive sleep apnea make each harder to manage, worsening the potential for heart-related complications.
  • Healthcare providers typically recommend treating insomnia and OSA simultaneously with a combination of cognitive behavioral therapy for insomnia and continuous positive airway pressure.

Resources We Trust

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
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Abhinav Singh

Abhinav Singh, MD

Medical Reviewer

Abhinav Singh, MD, is a board-certified sleep medicine specialist and the medical director of the Indiana Sleep Center. He is also an associate clinical professor at Marian Univers...

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Lauren Bedosky

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Lauren Bedosky is an experienced health and fitness writer. She regularly contributes to top websites and publications like Men's Health, Women's Health, MyFitnessPal, SilverSneake...