Kick Your Cough to the Curb With These OTC Cough Syrups, Recommended by Doctors
We’ve all had it before: a persistent cough that makes everything difficult — sleeping through the night, focusing on work, or simply getting through the day. An over-the-counter (OTC) cough syrup is a common solution, but not all cough medicines are equal, and choosing the right product depends on the type of cough you're dealing with.
Cough syrups generally fall into two categories: suppressants and expectorants. "A cough suppressant helps reduce how often and how hard you cough,” says Allie Buttarazzi, MD, a diplomate of the American Board of Lifestyle Medicine and double board-certified physician who is co-owner of Maine Street Medical in Brunswick. “I recommend them when you have a persistent, dry cough. An expectorant thins mucus so you can clear it more easily,” Dr. Buttarazzi explains, “and can be helpful if you have a ‘junky,’ productive cough but can't seem to bring the mucus up.”
Because the cough syrup aisle is crowded with options, some of which also contain decongestants, pain relievers, and antihistamines, we spoke with three board-certified physicians to see what they most often recommend for common coughs. Here are the best OTC cough syrups that we trust to help you breathe, sleep, and get through the day.
Our Top Picks
- Best for adults: Robitussin Honey Cough and Chest Congestion DM
- Best for young kids: Zarbee's Children’s Daytime Cough Syrup+Immune
- Best for wet coughs: Mucinex Fast-Max DM MAX
- Best multisymptom: Robitussin Cough and Chest Congestion DM
- Best nondrowsy formula: Delsym Adult Cough Suppressant Liquid
- Best for nighttime relief: Robitussin Maximum Strength Nighttime Cough DM
- Best for allergies: Benadryl Allergy Liquid
When To Consult Your Doctor
While a mild cough from the common cold often improves on its own, persistent coughs lasting longer than eight weeks should be evaluated by your doctor. Additionally, if you experience symptoms such as shortness of breath, headaches, drowsiness, or a high fever, or are coughing up mucus that is yellowish-green or bloody, you should seek medical attention immediately. “For kids under 4, most pediatricians do not recommend OTC cough syrups,” says Chrissie Ott, MD, multi-board-certified physician practicing in Portland, Oregon. “If a young child is coughing and needs symptom management, a physician's input is warranted.”
/cvs-robitussin-honey-cough-chest-congestion-dm-adult-max-strength-liquid-syrup-500x500.jpg?sfvrsn=a05322d0_3)
Best for Adults
Robitussin Honey Cough and Chest Congestion DM
Pros
- Contains both cough suppressant and expectorant
- Contains Grade A True Source Certified honey
- Free from artificial colors and flavors, gluten-free
- Soothing honey flavor
Cons
- Only for adults, children 12 and older
- Not recommended for those taking MAOIs
Key Specs
- Active ingredients: dextromethorphan HBr (20 mg), guaifenesin (400 mg)
- Dosage: 20 mL
- Targeted symptoms: cough, chest congestion, mucus
- Age range: adults, children 12 years and older
- Flavor: honey

Best for Young Kids
Zarbee's Children’s Daytime Cough Syrup+ Immune
Pros
- Drug-free cough relief for young children
- Contains dark honey, vitamin D, zinc
- Free from alcohol, artificial sweeteners, flavors, dyes
- No gluten, dairy, egg, or peanut
Cons
- Not suitable for children under 2
- Mixed Berry flavor may not appeal to all
Key Specs
- Active ingredients: dark honey, vitamin D, zinc, elderberry fruit extract
- Dosage: 5 mL
- Targeted symptoms: cough
- Age range: children 2 and older
- Flavor: Mixed Berry
When it comes to cough syrups for young kids, Dr. Ott only recommends treating a cough “when it’s interfering significantly with sleep or causing pain.” Otherwise, coughing is a good thing — it’s necessary to help move mucus the body is trying to eliminate, she explains. However, if your pediatrician has ruled out other causes of coughing, such as asthma and pneumonia, Ott recommends honey or a cough syrup like Zarbee’s, which contains honey to coat and soothe the throat. We love Zarbee’s Cough Syrup+Immune because, in addition to dark honey, it also contains three additional ingredients that may help support immune health — vitamin D, zinc, and elderberry fruit extract.

Best for Wet Coughs
Mucinex Fast-Max DM MAX
Pros
- Contains both cough suppressant and expectorant
- Nondrowsy
- Free from artificial colors, dyes, alcohol, sugar
Cons
- Only for ages 12 and older
- Not recommended for those taking MAOIs
Key Specs
- Active ingredients: dextromethorphan HBr (20 mg), guaifenesin (400 mg)
- Dosage: 20 mL
- Targeted symptoms: chest congestion, cough, mucus
- Age range: adults, children 12 and older
- Flavor: Honey & Berry, Berry
We also liked that this product is sugar-free. Instead, it contains sorbitol and sucralose as sweeteners. It's also a nondrowsy formula that can be used during the day or night, so you don't need to purchase multiple products — this one covers you all day. Like many other cough syrups, it's not recommended for children under 12. Additionally, people taking prescription MAOIs should consult their doctor before using this product.
/walgreens-robitussin-cough-chest-congestion-liquid-medicine-raspberry-500x500.jpg?sfvrsn=631a6959_3)
Best Multisymptom
Robitussin Cough and Chest Congestion DM
Pros
- Contains both cough suppressant and expectorant
- Contains soothing menthol
- Nondrowsy
- Alcohol-free
Cons
- Only for adults, children 12 and older
- Not recommended for those taking MAOIs
Key Specs
- Active ingredients: dextromethorphan HBr (20 mg), guaifenesin (200 mg)
- Dosage: 20 mL
- Targeted symptoms: chest congestion, cough, mucus
- Age range: adults, children 12 and older
- Flavor: Berry
“I'm not a fan of most ‘all-in-one’ formulas,” says Buttarazzi, “as they often pack in four or more ingredients you may not need and can make it easy to double up on ingredients, such as acetaminophen.” However, Buttarazzi notes that Robitussin Cough and Chest Congestion DM is different. “It combines dextromethorphan to quiet a cough,” she explains, “and guaifenesin to thin and loosen mucus — nothing extra.”
/walgreens-delsym-adult-cough-relief-liquid-orange-500x500.jpg?sfvrsn=c71bb3a8_3)
Best Nondrowsy Formula
Delsym Adult Cough Suppressant Liquid
Pros
- Nondrowsy
- Only 1 active ingredient
- Relieves cough for up to 12 hours
- Alcohol-free
Cons
- Doesn’t relieve congestion or mucus
- Not recommended for those taking MAOIs
Key Specs
- Active ingredients: dextromethorphan polistirex extended release (each 5 mL contains the equivalent of 30 mg dextromethorphan HBr)
- Dosage: Adults, children 12 and older: 10 mL; ages 6–12: 5 mL; ages 4–6: 2.5 mL
- Targeted symptoms: cough
- Age range: adults, children 4 and older
- Flavor: Orange
“Delsym keeps it simple with a single active ingredient — dextromethorphan,” says Buttarazzi, “making it a solid choice for a dry, nagging daytime cough.” She adds that most people find it nonsedating, but that everyone has unique body chemistry, so it's best to try it at home first to see how you respond.
We also appreciated that this cough syrup contains a time-release form of dextromethorphan, which can provide relief for up to 12 hours. This is more convenient than many of the other cough syrups on this list, which typically need to be taken every four hours. Plus, because it only contains dextromethorphan, it can be used for children ages 4 and older; most other cough syrups that contain an expectorant are not appropriate for children under 12 years.
However, because it doesn't contain an expectorant, it may not be the best choice for individuals with a wet cough or congestion caused by excessive mucus. It also contains sugar, which may not be preferred by some people.

Best for Nighttime Relief
Robitussin Maximum Strength Nighttime Cough DM
Pros
- Contains dextromethorphan and antihistamine
- Contains soothing menthol
- Multisymptom relief
- Alcohol-free
Cons
- May increase risk of urinary retention, morning grogginess
- Not recommended for those taking MAOIs
Key Specs
- Active ingredients: dextromethorphan HBr (30 mg), doxylamine succinate (12.5 mg)
- Dosage: 20 mL
- Targeted symptoms: Cough, runny nose, sneezing, itchy-watery eyes, nose, throat
- Age range: adults, children 12 and older
- Flavor: Wildberry
Buttarazzi generally recommends choosing nondrowsy cough syrups like the ones listed above, even at night, because the nighttime syrups typically rely on sedating antihistamines. However, if coughing is truly keeping you from sleeping, she recommends Robitussin Maximum Strength Nighttime Cough DM, noting that it only contains a low dose of antihistamine (plus dextromethorphan to help suppress a cough).
/cvs-benadryl-allergy-liquid-relief-500x500.jpg?sfvrsn=f375b90e_3)
Best for Allergies
Benadryl Allergy Liquid
Pros
- Contains diphenhydramine
- Relieves cold and allergy symptoms
- Alcohol-free
- Affordable
Cons
- Doesn’t contain an expectorant
- May cause drowsiness
Key Specs
- Active ingredients: diphenhydramine HCl (12.5 mg per 5 mL)
- Dosage: Adults, children 12 and older: 10–20 mL; ages 6–11: 5–10 mL
- Targeted symptoms: runny nose, sneezing, itchy-watery eyes, nose, throat, cough due to allergies or cold
- Age range: adults, children 6 and older
- Flavor: Wild Cherry
Finally, although Benadryl Allergy Liquid is effective in relieving coughs associated with allergies or the common cold, it doesn’t contain an expectorant, so it may not be helpful for people with a wet cough or excessive mucus. However, if you're experiencing a dry cough or other allergy-like symptoms, this is an effective option.
Comparison Table
Dextromethorphan HBr, guaifenesin
Cough, mucus, chest congestion
Dark honey, vitamin D, zinc, elderberry, fruit extract
Cough, immune support
Dextromethorphan HBr, guaifenesin
Cough, chest congestion, mucus
Dextromethorphan HBr, guaifenesin
Cough, chest congestion, mucus
Dextromethorphan polistirex
Adults, children 12 and older: 10 mL, ages 6–12: 5 mL, ages 4–6: 2.5 mL
Cough
Dextromethorphan HBr, doxylamine succinate
Cough, runny nose, sneezing
Adults, children 12 and older: 10–20 mL, ages 6–11: 5 mL
Sneezing, runny nose, itchy-watery eyes, throat or nose, cough
How We Chose the Best OTC Cough Syrups
You deserve recommendations you can trust, which is why we compiled this list using a clear, evidence-informed process. To ensure accuracy and safety, we consulted three board-certified physicians:
- Allie Buttarazzi, MD, a diplomate of the American Board of Lifestyle Medicine and double board-certified physician who is co-owner of Maine Street Medical in Brunswick
- Heather Gosnell, MD, board-certified pediatrician in Phoenix
- Chrissie Ott, MD, multi-board-certified physician in Portland, Oregon
Their insights helped us evaluate how different OTC cough syrups work and which ones are most appropriate for different individuals and situations. We considered factors like active ingredients, alcohol and sugar content, dosage and frequency, flavor, age range, and price. By weighing these criteria with input from our experts, we identified the OTC cough syrups most likely to provide safe and effective relief for a range of different types of cough.
What to Look For When Buying OTC Cough Syrups
Not all cough syrups work the same way, so it's important to choose one that's designed to treat the symptoms you're experiencing. Here are some factors to keep in mind when shopping for OTC cough syrups:
- Active Ingredients Look for expectorants (like guaifenesin) if you have a wet cough and need to loosen mucus, suppressants (like dextromethorphan) if you have a dry, hacking cough, or antihistamines (like diphenhydramine) if your cough is related to allergies.
- Age Range Many cough syrups aren't safe for young children, so it's important to choose products designed for the age range of the person taking the medication.
- Dosage and Frequency Determine how often you'll need to take it and ensure it aligns with your schedule. Some cough syrups contain timed-release ingredients, which may be more convenient, as you don't need to take them as often.
- Alcohol or Sugar Content People with diabetes, children, or those avoiding alcohol may need to avoid cough syrups with these ingredients.
FAQs
A cough suppressant (like dextromethorphan) helps reduce the frequency and severity of a cough, and can be useful when you have a persistent, dry cough. In contrast, she explains that an expectorant (like guaifenesin) helps thin mucus, making it easier to clear. This makes it a good choice if you have a wet, productive cough but are struggling to clear the mucus.
“I tell my patients to look for dextromethorphan if they need a suppressant and guaifenesin if they need an expectorant,” says Buttarazzi. As for ingredients to avoid, “I generally recommend skipping products with a decongestant like phenylephrine, since it isn't very effective,” she adds.
Buttarazzi also recommends avoiding antihistamines like doxylamine or diphenhydramine unless absolutely necessary, as they can make you drowsy. Finally, “I also steer patients away from combination syrups that contain acetaminophen,” she explains, “and if you do need it, it's best to take it separately so you can control the dose.”
“OTC cough syrups are unsafe for children under 4,” says Heather Gosnell, MD, a board-certified pediatrician in Phoenix, “and not recommended under 6, as studies show no benefit in younger kids.” She adds that these medications can cause harmful side effects in children, including a faster heart rate, restlessness, confusion, and sleepiness.
When choosing a cough syrup for children, Ott recommends selecting single-ingredient cough syrups whenever possible to avoid overdosing on other ingredients, such as antihistamines and decongestants.
For most people, there aren't many downsides to taking OTC cough syrups, says Buttarazzi. However, some people may notice mild drowsiness from dextromethorphan and added antihistamines, so try your first dose when you don't need to drive or work, she adds.
“Nighttime cough syrups have not been shown to improve sleep in children,” says Gosnell. For adults, Buttarazzi generally recommends nondrowsy options unless absolutely necessary, as many nighttime syrups rely on sedating antihistamines that can leave you groggy in the morning and may increase the risk of urinary retention, especially in older adults.
If you choose to use cough syrups for your children, Gosnell recommends sugar-free and alcohol-free versions. “Sugar offers no symptom relief and can cause tooth decay and provide excess calories,” she explains, “while alcohol also provides no benefit and may cause central nervous system depression, low blood sugar, and accidental overdose.”
Why Trust Everyday Health

Sarah Glinski, RD
Author
Sarah is a registered dietitian and accomplished health and nutrition writer known for her expertise in crafting engaging content. She received dual bachelor’s degrees in nutrition...

Justin Laube, MD
Medical Reviewer
Justin Laube, MD, is a board-certified integrative and internal medicine physician, a teacher, and a consultant with extensive expertise in integrative health, medical education, a...

Daniel Oakley
Fact-Checker
Daniel Oakley is a journalist, editor, and fact-checker. He has written, edited, taught, and produced media for Dow Jones, S&P Global, IHS Markit, Third Coast Studios Magazine, and...

Lili Ladaga
Editor
- Ouaamr A et al. The Effects of Honey on Cough and Sleep Quality in Adults with Acute Respiratory Infections. Chinese Journal of Otorhinolaryngology Head and Neck Surgery. August 2023.
- Oh S et al. Dextromethorphan. StatPearls. May 22, 2023.
- Kapruia R et al. Dextromethorphan Guaifenesin. StatPearls. May 25, 2024.
- Dextromethorphan. National Library of Medicine. January 15, 2022.
- Bikle DD. Vitamin D Regulation of Immune Function. Current Osteoporosis Reports. June 1, 2022.
- Maywald M et al. Zinc in Human Health and Infectious Diseases. Biomolecules. November 24, 2022.
- Wieland LS et al. Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review. BMC Complementary Medicine and Therapies. April 7, 2021.
- Van Horn NL et al. Infantile Botulism. StatPearls. April 6, 2025.
- FDA Proposes Ending Use of Oral Phenylephrine as OTC Monograph Nasal Decongestant Active Ingredient After Extensive Review. U.S. Food and Drug Administration. November 7, 2024.
- DeGeorge KC et al. Treatment of the Common Cold. American Family Physician. September 1, 2019.
- Brott N et al. Doxylamine. StatPearls. June 5, 2023.
- Diphenhydramine. MedlinePlus. August 15, 2025.
- Lam SH et al. Use of antitussive medications in acute cough in young children. Journal of the American College of Emergency Physicians Open. June 18, 2021.