Ziftomenib (Oral)
Ziftomenib is used in adults to treat a certain type of acute leukemia that has come back or failed other treatments and who have no other treatment options.
Your doctor will make sure you have the correct gene mutation to be treated with ziftomenib.
Ziftomenib may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know about Ziftomenib (Oral)?
Tell your doctor if you have or have ever had:
- heart problems;
- long QT syndrome; or
- an electrolyte imbalance (such as low blood levels of potassium or magnesium).
Ziftomenib can harm an unborn baby if the mother or the father is using this medicine.
- If you are a woman, you may need to have a pregnancy test before starting this treatment. Use birth control while using this medicine and for at least 6 months after your last dose.
- If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
- Tell your doctor right away if a pregnancy occurs.
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
Ziftomenib may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.
Side Effects
What are the side effects of Ziftomenib (Oral)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Ziftomenib can cause a condition called differentiation syndrome, which affects blood cells and can be life-threatening or fatal if not treated. This condition may occur as early as 3 days or later after you start taking ziftomenib. Seek medical help right away if you have symptoms of differentiation syndrome: fever, joint pain, bone pain, dizziness, trouble breathing, cough, chest pain, rapid weight gain, rash, decreased urination, or swelling in your arms or legs.
You may feel faint while taking ziftomenib. Call your doctor right away if you have fast or pounding heartbeats, shortness of breath, and sudden dizziness.
Your cancer treatments may change, be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- infections, including caused by bacteria;
- bleeding;
- diarrhea, nausea;
- tiredness;
- swelling in your arms and legs;
- bone pain, muscle or joint pain;
- itching;
- abnormal blood tests (including changes in liver function tests); or
- fever with low white blood cell counts.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Ziftomenib (Oral) if I’m pregnant or breastfeeding?
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
Interactions
What drugs and food should I avoid while taking Ziftomenib (Oral)?
Avoid taking a stomach acid reducer such as omeprazole, pantoprazole, esomeprazole, and others.
Avoid taking a stomach acid reducer (such as famotidine, cimetidine, ranitidine, and others) within 2 hours before or 10 hours after you take ziftomenib.
Avoid taking an antacid (such as calcium carbonate) within 2 hours before or 2 hours after you take ziftomenib.
Dosage Guidelines & Tips
How to take Ziftomenib (Oral)?
Use Ziftomenib (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Ziftomenib is usually taken once per day, around the same time each day.
Take on an empty stomach, at least 1 hour before or 2 hours after a meal.
Swallow the capsule whole and do not chew, break, or open it.
You may be given other medications to treat serious side effects. Keep taking these medicines for as long as your doctor has prescribed.
Do not change your dose or stop taking this medication without your doctor's advice.
Your heart function and blood will need to be tested before and during treatment. Your treatment may be changed based on the results.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can on the same day and at least 12 hours before your next dose. Go back your regular schedule the following day. Do not take two doses within 12 hours.