Pegzilarginase (Injectable)
Pegzilarginase is used in adults and children 2 years and older to treat high levels of arginine who have a condition called arginase 1 deficiency (ARG1-D). People using this medicine should also follow a special diet that limits protein.
Pegzilarginase may also be used for purposes not listed in this medication guide.
uses
What is Pegzilarginase (Injectable) used for?
- Arginase Deficiency
warnings
What is the most important information I should know about Pegzilarginase (Injectable)?
You should not use pegzilarginase if you are allergic to it.
Tell your doctor if you have or ever had health problems, use other medications, or had any previous allergic reactions.
Tell your doctor if you are pregnant or breastfeeding.
Side Effects
What are the side effects of Pegzilarginase (Injectable)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.
Common side effects may include:
- vomiting;
- fever; or
- constipation.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Pegzilarginase (Injectable) if I’m pregnant or breastfeeding?
Tell your doctor if you are pregnant or breastfeeding.
Interactions
What drugs and food should I avoid while taking Pegzilarginase (Injectable)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Pegzilarginase (Injectable)?
Use Pegzilarginase (Injectable) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Pegzilarginase is injected into a vein usually once every week. A healthcare provider will give you this injection.
You may be given other medications to help prevent serious side effects or allergic reaction. Keep taking these medicines for as long as your doctor has prescribed.
You will be watched for a short time to make sure you do not have an allergic reaction.
After 8 weeks, your provider may switch you to injections under the skin at the same dose.
If you tolerate injections under the skin and your provider approves, you may be able to receive pegzilarginase injections at home, but only under the supervision of a healthcare provider.
You will need regular blood tests to check your arginine levels and to monitor for side effects.
Doses are based on weight. Your dose may change if you gain or lose weight.
You may need to follow a special diet. Follow all instructions of your doctor or dietitian. Learn about the foods you should eat or avoid.
Call your doctor for instructions if you miss an appointment for your pegzilarginase injection.
Overdose Signs
What happens if I overdose on Pegzilarginase (Injectable)?
In a medical setting an overdose would be treated quickly.