Panzyga (Intravenous)
Immune globulin (IGIV) is used in adults and children at least 2 years old to treat primary immunodeficiencies such as X-linked agammaglobulinemia, common variable immunodeficiency, congenital agammaglobulinemia, Wiskott-Aldrich syndrome and severe combined immunodeficiencies.
Immune globulin is also used in adults and children at least 15 years old with idiopathic thrombocytopenic purpura (ITP) to increase platelet counts and help prevent or control bleeding.
Immune globulin is also used to help prevent certain infections in people with low levels of immune globulin (hypogammaglobulinemia) or in those with B-cell chronic lymphocytic leukemia.
Immune globulin is also used to prevent coronary artery aneurysms in children with Kawasaki syndrome.
Immune globulin may also be used in adults with chronic inflammatory demyelinating polyneuropathy (CIDP) to improve nerve and muscle function and reduce disability.
Immune globulin may also be used for purposes not listed in this medication guide.
uses
What is Panzyga (Intravenous) used for?
- Idiopathic (Immune) Thrombocytopenic Purpura
- Kawasaki Disease
- Primary Immunodeficiency Syndrome
- Chronic Lymphocytic Leukemia
warnings
What is the most important information I should know about Panzyga (Intravenous)?
You should not use immune globulin if you are allergic to it, or if you have:
- hyperprolinemia (high level of a certain amino acid in the blood);
- hereditary fructose intolerance, a condition that makes it hard for you to digest fructose sugars (such as in certain fruits or juices);
- immune globulin A (IgA) deficiency with antibody to IgA; or
- an allergy to corn.
Tell your doctor if you have or have ever had:
- migraine headaches;
- high blood pressure; or
- kidney disease.
Immune globulin can cause blood clots or kidney problems, especially in older adults or in people with certain health conditions. Tell your doctor if you have ever had heart or blood circulation problems, a stroke or blood clot, kidney disease, diabetes, paraproteinemia, or an infection such as sepsis, and if you use estrogens (including birth control pills or hormone replacement therapy), have been on long-term bed rest, or have a central intravenous (IV) catheter in place.
It is not known if immune globulin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
Immune globulin is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.
Side Effects
What are the side effects of Panzyga (Intravenous)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.
Call your doctor at once if you have:
- neck stiffness, increased sensitivity to light, painful eye movement, nausea, drowsiness;
- frequent vomiting, stomach pain;
- pounding in your neck or ears;
- abnormal blood tests (including low blood sugar and low blood sodium);
- a blood cell disorder--pale or yellowed skin, dark colored urine, or weakness;
- dehydration--dizziness, confusion, feeling very thirsty;
- kidney problems--swelling, urinating less, shortness of breath, rapid weight gain;
- lung problems--chest pain, trouble breathing, blue colored lips, fingers, or toes;
- signs of infection--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding; or
- signs of a blood clot--sudden numbness or weakness on one side of the body, sudden cough or shortness of breath, chest pain, problems with vision or speech, pain or swelling in one leg.
Common side effects may include:
- headache, pain, muscle or joint pain, swelling in your joints;
- fever, chills, sweating, flushing;
- stomach pain, nausea, vomiting, diarrhea;
- painful or difficult urination;
- increased blood pressure, fast heartbeats, dehydration, feeling like you might pass out;
- itching, rash, hives, dry skin;
- low blood cell counts;
- dizziness, tiredness, lack of energy, discomfort;
- stuffy nose or swelling in your nose, sneezing, sinus pain, cough, sore throat; or
- pain, swelling, burning, or irritation around the IV needle.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Panzyga (Intravenous) if I’m pregnant or breastfeeding?
It is not known if immune globulin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
Interactions
What drugs and food should I avoid while taking Panzyga (Intravenous)?
Avoid receiving a "live" vaccine. The vaccine may not work as well while you are using immune globulin. Live vaccines may include measles, mumps, rubella (MMR), varicella (chickenpox), nasal flu vaccine, and others.
Dosage Guidelines & Tips
How to take Panzyga (Intravenous)?
Use Panzyga (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Immune globulin is given as an infusion into a vein. A healthcare provider will give you this injection.
Doses are based on weight. Your dose may change if you gain or lose weight.
You may need a dose adjustment if you are exposed to measles, or if you travel to an area where this disease is common.
Drink plenty of liquids while you are using this medicine to help improve your blood flow and keep your kidneys working properly.
You may be given other medications to treat certain allergic reactions or serious side effects.
You will be watched for a short time to make sure you do not have an allergic reaction.
You will need frequent medical tests. Your blood pressure will be constantly monitored, and your kidney function may need to be checked often.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using immune globulin.
Call your doctor for instructions if you miss an appointment for your immune globulin injection.
Overdose Signs
What happens if I overdose on Panzyga (Intravenous)?
In a medical setting an overdose would be treated quickly.