Orforglipron (Oral)
Orforglipron is used with diet and exercise to manage weight in overweight or obese adults who also have at least one weight-related medical condition.
Orforglipron may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know about Orforglipron (Oral)?
You should not use orforglipron if you are allergic to it or any of its ingredients, or if you have:
- a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer); or
- multiple endocrine neoplasia type 2 (tumors in your glands).
Tell your doctor if you have or have ever had:
- pancreas problems;
- a severe stomach problem such as problems with digesting food or slowed emptying of your stomach (gastroparesis);
- diabetes, eye problems caused by diabetes;
- a planned surgery or any other medical procedure;
- severe liver disease; or
- kidney disease.
If you need surgery or a medical procedure, tell your doctor or surgeon ahead of time that you are using this medicine.
May harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of orforglipron on the baby.
Orforglipron can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge. If you take birth control pills you may need to use different birth control options for 30 days after starting this medicine and for 30 days each time the dose is increased.
Ask a doctor if it is safe to breastfeed while using this medicine.
Side Effects
What are the side effects of Orforglipron (Oral)?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- changes in your vision;
- severe stomach problems--diarrhea, constipation, or stomach pain;
- signs of a thyroid tumor--swelling or a lump in your neck, trouble swallowing, a hoarse voice, or if you feel short of breath;
- pancreas or gallbladder problems--severe pain in your upper stomach spreading to your back, nausea and vomiting, chalky-colored stools, stomach pain after eating, heartburn, and bloating;
- low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or
- kidney problems--swelling, urinating less, or feeling tired.
Common side effects may include:
- hair loss;
- tiredness;
- headache;
- nausea, vomiting, diarrhea; or
- heartburn, burping, bloating, constipation, gas, or stomach pain or upset.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Orforglipron (Oral) if I’m pregnant or breastfeeding?
May harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of orforglipron on the baby.
Orforglipron can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge. If you take birth control pills you may need to use different birth control options for 30 days after starting this medicine and for 30 days each time the dose is increased.
Ask a doctor if it is safe to breastfeed while using this medicine.
Interactions
What drugs and food should I avoid while taking Orforglipron (Oral)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Orforglipron (Oral)?
Use Orforglipron (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Orforglipron is usually taken once per day with or without food. Follow your doctor's instructions.
Swallow the tablet whole and do not crush, chew, or break it.
Your treatment may also include diet, exercise, weight control, and special medical care.
You may get dehydrated during prolonged illness. Call your doctor if you are sick with vomiting or diarrhea, or if you drink liquids less than usual.
Store this medicine in the original bottle and carton at room temperature away from moisture, heat, and light. Replace cap after each dose.
Take the medicine as soon as you remember, and then go back to your regular schedule. Do not take two doses at one time.
If you miss doses for 7 or more days, call your doctor for instructions on how to restart your medicine.
Overdose Signs
What happens if I overdose on Orforglipron (Oral)?
Images
L, G1
Color: pink
Shape: round
Form: film coated
Imprint: L, G1
L, G3
Color: purple
Shape: round
Form: film coated
Imprint: L, G3
L, G2
Color: yellow
Shape: round
Form: film coated
Imprint: L, G2