Psyllium Supplement 101: Potential Benefits, Known Risks, and More

Note: The U.S. Food and Drug Administration (FDA) does not approve supplements for safety or effectiveness. Talk to a healthcare professional about whether a supplement is the right fit for your individual health, and about any potential drug interactions or safety concerns.
Recently, TikTok has popularized psyllium — a fiber supplement known primarily as the main ingredient in many over-the-counter laxatives — as "budget Ozempic" for its purported weight loss effects.
Here’s a closer look at what the evidence says about how psyllium may impact health, who may want to take it, and possible side effects to look out for.
Potential Health Benefits of Psyllium
May Help Relieve IBS Symptoms
Still, experts believe it may have potential: “Psyllium absorbs water and forms a gel-like substance that softens stools and promotes regularity,” says Dawn Jackson Blatner, RDN, a Chicago-based nutrition specialist and author of The Superfood Swap. “[It] acts like a gentle sponge for your digestive system and can be especially helpful for people dealing with IBS,” she adds.
May Benefit the Gut Microbiome
“Psyllium feeds good gut bacteria, which supports a healthier gut microbiome overall,” says Blatner.
May Improve Cholesterol Levels
May Help Lower Fasting Blood Sugar
Psyllium may help lower fasting blood sugar, overall blood sugar management, and insulin resistance. “Psyllium slows the digestion and absorption of carbohydrates, which can help to prevent spikes in blood sugar levels,” says Kenneth Brown, MD, a gastroenterologist in Plano, Texas, and host of the Gut Check Project podcast.
A review of 19 studies including 962 participants conducted in eight different countries found that psyllium significantly lowered fasting blood sugar, HbA1C (a measure of long-term blood sugar levels), and insulin resistance compared to a placebo.
Weight Loss Effect of Psyllium
But experts say soluble fibers like psyllium may have an indirect effect on weight loss by curbing your appetite. “All types of fiber help with feelings of fullness, as long as you're taking plenty of fluid,” says Lauri Wright, PhD, RDN, the director of nutrition programs at the University of South Florida College of Public Health in Tampa, Florida. “So that can be a weight loss strategy, but I would recommend food first — then supplements, if needed.”
Potential Risks and Side Effects of Psyllium
As with any supplement, psyllium comes with potential risks and side effects.
Also keep in mind that the FDA regulates dietary supplements differently than conventional foods and drug products — manufacturers are responsible for evaluating the safety and labeling of their own products.
Risks
- digoxin (Lanoxin), a cardiac drug
- salicylates (aspirin)
- nitrofurantoin (Macrodantin, Furadantin, Macrobid), which is used to treat urinary tract infections (UTIs)
Side Effects
Forms of Psyllium
While psyllium comes in a number of forms, the powder form is perhaps the most versatile. “Psyllium can easily be added to things like water, smoothies, or other liquids to promote bowel regularity and overall digestive health,” says Samantha Schleiger, RDN, owner of Simply Nourished Functional Nutrition in Elkhorn, Wisconsin.
Other forms of psyllium available for purchase include:
- Capsules
- Gummies
- Thins, or wafers
- Husks (whole food)
- Seeds (whole food)
“All forms are effective when paired with an 8-ounce (oz) cup of water, and taken as directed on the packaging,” notes Brooke Levine, RD, a weight loss nutritionist at NYU Langone Health in New York City.
How to Select and Store Psyllium
When purchasing psyllium, there are a few things you should keep in mind. Similarly, you’ll also want to ensure you safely store your supplements.
Selection
To choose a quality supplement, check the label for USP, NSF, or ConsumerLabs Approved. This means the product has undergone third-party testing for quality and purity. When selecting a type of psyllium to purchase, Brown recommends opting for pure psyllium husk with just that one ingredient.
“Other fibers will sometimes add sugar, sugar substitutes, binders, or artificial flavors, all to make it more palatable,” he says. “Most of this is for marketing purposes.”
Storage
It’s also important to store psyllium correctly to keep it fresh and prevent contamination. Schleiger recommends storing psyllium in a cool, dry place inside a sealed container. “Store away from light, moisture, or heat to prevent the chances of the psyllium going bad or mold growth,” she says.
Dosage of Psyllium
The right amount of psyllium to take varies from person to person, and it’s important to check with your doctor about your specific needs. “Dosage should be individualized and adjusted based on a person's overall gut health and tolerance,” Schleiger says. Some people may respond better or worse to psyllium, so guidance from a certified healthcare practitioner is key, she adds.
The Takeaway
- Psyllium is a fiber that may help relieve constipation and regulate bowel movements. It comes in whole food and supplement forms.
- Research suggests it may have additional potential health benefits, including lowering cholesterol and blood sugar levels, which can reduce the risk of heart disease or support diabetes management. It also may aid weight loss, but the research is mixed.
- Talk to your doctor before introducing psyllium or any supplement into your diet, especially if you have health conditions or are taking other medications, as there may be drug interactions you need to be aware of.
FAQ
- Dietary Guidelines for Americans. U.S. Department of Agriculture. December 2020.
- Garg P et al. Psyllium Husk Positively Alters Gut Microbiota, Decreases Inflammation, and Has Bowel-Regulatory Action, Paving the Way for Physiologic Management of Irritable Bowel Syndrome. Gastroenterology. March 2024.
- Martellet MC et al. Probiotic Applications Associated With Psyllium Fiber as Prebiotics Geared to a Healthy Intestinal Microbiota: A Review. Nutrition. August 2, 2022.
- Gut Microbiome. Cleveland Clinic. August 18, 2023.
- U.S. Food and Drug Administration. Food Labeling: Health Claims; Soluble Fiber From Certain Foods and Coronary Heart Disease. Federal Register. February 18, 1998.
- Federal Register. U.S. Food and Drug Administration. February 18, 1998.
- Gholami Z et al. The effect of psyllium on fasting blood sugar, HbA1c, HOMA IR, and insulin control: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials. BMC Endocrine Disorders. June 6, 2024.
- Franco EAN et al. Psyllium (Plantago Ovata Forsk): From Evidence of Health Benefits to its Food Application. Trends in Food Science & Technology. February 2020.
- Darooghegi Mofrad M et al. The Effects of Psyllium Supplementation on Body Weight, Body Mass Index and Waist Circumference in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. Critical Reviews in Food Science and Nutrition. March 18, 2019.
- Gholami Z et al. ‘Effect of Psyllium Consumption on Metabolic Syndrome Indices: Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials. Journal of Functional Food. August 2023.
- Chart of High-Fiber Foods. Mayo Clinic. November 23, 2023.
- Psyllium. Mount Sinai.
- Psyllium. MedlinePlus. June 20, 2024.
- By the Way, Doctor: Will a Fiber Supplement Interfere With My Medications? Harvard Medical School. August 23, 2019.
- Psyllium Powder for Solution. Cleveland Clinic.
- Gholami Z et al. The effect of psyllium on fasting blood sugar, HbA1c, HOMA IR, and insulin control: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials. BMC Endocrine Disorders. June 6, 2024.
- Psyllium Powder of Suspension. Cleveland Clinic.

Justin Laube, MD
Medical Reviewer
Justin Laube, MD, is a board-certified integrative and internal medicine physician, a teacher, and a consultant with extensive expertise in integrative health, medical education, and trauma healing.
He graduated with a bachelor's in biology from the University of Wisconsin and a medical degree from the University of Minnesota Medical School. During medical school, he completed a graduate certificate in integrative therapies and healing practices through the Earl E. Bakken Center for Spirituality & Healing. He completed his three-year residency training in internal medicine at the University of California in Los Angeles on the primary care track and a two-year fellowship in integrative East-West primary care at the UCLA Health Center for East-West Medicine.
He is currently taking a multiyear personal and professional sabbatical to explore the relationship between childhood trauma, disease, and the processes of healing. He is developing a clinical practice for patients with complex trauma, as well as for others going through significant life transitions. He is working on a book distilling the insights from his sabbatical, teaching, and leading retreats on trauma, integrative health, mindfulness, and well-being for health professionals, students, and the community.
Previously, Dr. Laube was an assistant clinical professor at the UCLA Health Center for East-West Medicine and the David Geffen School of Medicine at UCLA, where he provided primary care and integrative East-West medical consultations. As part of the faculty, he completed a medical education fellowship and received a certificate in innovation in curriculum design and evaluation. He was the fellowship director at the Center for East-West Medicine and led courses for physician fellows, residents, and medical students.

Ashley Welch
Author
Ashley Welch has more than a decade of experience in both breaking news and long-form storytelling. She is passionate about getting to the crux of the latest scientific studies and sharing important information in an easy-to-digest way to better inform decision-making. She has written about health, science, and wellness for a variety of outlets, including Scientific American Mind, Healthline, New York Family, Oprah.com, and WebMD.
She served as the health editor for CBSNews.com for several years as a reporter, writer, and editor of daily health news articles and features. As a former staff member at Everyday Health, she covered a wide range of chronic conditions and diseases.
Welch holds a bachelor's degree from Fordham University and a master's degree from the Craig Newmark Graduate School of Journalism at the City University of New York, where she studied health and science reporting. She enjoys yoga and is an aspiring runner.

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Kelsey Kloss is a health and wellness journalist with over a decade of experience. She started her career as an in-house editor for brands including Reader’s Digest, Elle Decor, Good Housekeeping, Prevention, Woman's Day, and Redbook, and her work has been featured in over 50 publications.