The 8 Best Dietitian-Approved Nitric Oxide-Boosting Supplements of 2026
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The 8 Best Nitric Oxide–Boosting Supplements of 2026, Recommended by Dietitians to Improve Your Performance and Heart Health

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Published on April 24, 2025
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Everyday Health independently vets all recommended products. If you purchase a featured product, we may be compensated. Learn why you can trust us.
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Nitric oxide, which is often shortened to “NO,” is a gas that’s naturally produced in the body. It plays a key role in a variety of biological tasks — especially when it comes to blood flow and circulation. NO helps relax your blood vessels to increase blood flow and lower blood pressure.

 If you’re interested in nitric oxide supplements, you should know that NO supplements don’t actually contain nitric oxide. Instead, they usually contain two nutrients that naturally boost NO production in your body: L-arginine and L-citrulline, which are amino acids known for their role in increasing NO production. L-arginine is converted to NO in your blood vessels by an enzyme called nitric oxide synthase (eNOS).

 Meanwhile, your kidneys convert L-citrulline to L-arginine, which converts to NO, making L-citrulline an indirect, but effective NO booster.

 In addition, nitrates, which are found in beetroot juice and powder, also increase NO, but in a different way than the eNOS process.

(We’re using the term “NO boosters” for these nitric oxide supplements, since that’s what people search for.)

So, who might be interested in taking an NO supplement?

A systematic review published in 2022 found that supplementing with L-arginine may help reduce blood pressure in adults with high blood pressure (hypertension).

 Research also found that taking 1,500 to 5,000 milligrams (mg) of L-arginine daily for two to six months, depending on the individual study, may improve erectile dysfunction, compared with a placebo or no treatment.

 In addition, L-citrulline may be beneficial when it comes to athletic performance. A review of available studies found that taking 2,400 to 6,000 milligrams of L-citrulline daily for 7 to 16 days increased nitric oxide synthesis and enhanced athletic performance.

To help you choose the best NO supplements, we consulted registered dietitians and looked for supplements that are third-party tested and made in Current Good Manufacturing Practices (CGMP)-certified facilities. Here are the eight nitric oxide-boosting supplements we recommend.

Our Top Picks for Nitric Oxide–Boosting Supplements

When to Consult Your Doctor

Everyday Health recommends speaking with your doctor before adding any supplement to your diet, to make sure it is safe and appropriate for your individual health needs. While nitric oxide is naturally produced in the body, Kaitlyn Comeau, RD, owner of KC Gaining Wellness in Nova Scotia, Canada, advises caution for people with heart conditions, low blood pressure, or those taking blood pressure medications.

It’s also important to note that NO supplements aimed at improving cardiovascular health and exercise performance are an evolving area of research, and many available supplements include a combination of compounds. The long-term benefits of individual and combination products, safety of longer term use, and ideal candidates for supplementation aren’t yet fully understood. It’s best to consult with your healthcare provider or a skilled integrative health practitioner before starting NO supplementation.

Best Liquid

Blonyx Beet-It Sport Nitrate 400

$49.95 at Amazon
$55.50Now 10% Off
Buy on Amazon $49.95

Pros

  • Convenient single-serving bottles
  • Only two ingredients
  • Additive-free, preservative-free
  • Vegan-friendly
  • Third-party tested
  • Produced in a CGMP-compliant facility

Cons

  • Strong beet flavor
  • May cause gastrointestinal issues after drinking

Key Specs

  • Form: Liquid
  • Serving size: One bottle, two to three hours before training, or two bottles on event day
  • NO-boosting ingredients: Nitrates from beet juice (400 mg)
  • Third-party tested: Yes

We didn’t find many liquid nitric oxide-boosting supplements in our research, but we loved Blonyx Beet-It Sport Nitrate 400 because it comes in convenient, single-serve bottles and is made with concentrated beet juice — a natural NO booster. For people looking for a natural way to boost NO production, these beet juice–based shots may be the perfect solution.

Research shows that beet juice, which contains nitrates, can significantly boost NO production and improve athletic performance.

 Specifically, beet juice may improve explosive exercise performance, sprint performance during short and intense bursts of activity, and increase training volume by enhancing muscle endurance.

 Studies show that nitrates are effective as a performance-enhancing aid when taken in doses of around 300 to 1,000 mg, two to three hours before exercise.

 Since this supplement contains 400 mg of nitrates from beet juice, it fits the bill.

We also love that these supplements are manufactured in a CGMP-certified facility, which means they follow strict guidelines for manufacturing, safety, and independent product-quality verification. These supplements are also NSF Certified for Sport and Informed Sport certified, which means they’ve been rigorously tested for banned substances, making this supplement ideal for competitive athletes who need assurance that the products they’re using are free of substances prohibited by sports governing bodies, such as the World Anti-Doping Agency. On the Blonyx website, you can request the certificate of analysis for all its supplements. This certificate shows detailed information about the contents and quality of a supplement and ensures that the product meets strict quality and safety standards.

Finally, in addition to getting the supplement, if you buy it from the Blonyx website, you also get a Beet It Sport Nitrate 400 guide and instructions on how to use it during the first month for success. Plus, if you use it as directed and don’t see an improvement in your performance, they’ll refund your money.

Best Powder

Type Zero Clean Stim-Free Preworkout + Nitric Oxide Booster

$32.95 at Amazon
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Pros

  • Convenient powder format
  • Contains L-citrulline, arginine AKG, beetroot extract
  • Sugar-free, caffeine-free
  • Third-party tested
  • Made in a CGMP-compliant facility
  • Four different flavors

Cons

  • Contains beta-alanine, which may cause a tingling sensation
  • Some users report headaches

Key Specs

  • Form: Powder
  • NO-boosting ingredients: L-citrulline malate (5,000 mg), arginine AKG (2,000 mg), beet root extract (1,000 mg)
  • Serving size: One scoop (15 grams), 15 to 30 minutes before a workout
  • Third-party tested: Yes

Type Zero Clean Stim-Free Preworkout + Nitric Oxide booster is our pick for the best powder nitric oxide booster, for several reasons. We like that unlike many powdered pre-workout/nitric oxide boosters, this one doesn’t contain any stimulants, such as caffeine. Since it’s not recommended that you consume caffeine close to bedtime, this powder can be used regardless of when you usually work out.

This supplement also contains both L-citrulline and arginine alpha-ketoglutarate (AKG), which is L-arginine that’s bonded with alpha-ketoglutarate, which can also support energy metabolism.

 Research shows that L-citrulline is better for promoting NO synthesis, as L-arginine is not well-absorbed in the intestines. In contrast, L-citrulline is well-tolerated and well-absorbed, making it ideal for stimulating NO production.

 For improving athletic performance, some benefits have been shown when taking doses of 6,000 to 8,000 mg of a combination of L-citrulline and malic acid around one hour before exercise.

 Most supplements that are third-party tested don’t contain this much, but this supplement comes close, at 5,000 mg of citrulline. It’s available in four different flavors (fruit punch, cherry limeade, pineapple orange mango, and blackberry lemonade), so there’s something for everyone to enjoy.
This supplement also contains beetroot powder. Beets contain nitrates, which stimulate NO production and may improve athletic performance.

 Type Zero also contains ingredients like chromium, gamma-aminobutyric acid (GABA), and beta-alanine. Chromium has been shown to significantly reduce fasting blood sugar and insulin levels in people with type 2 diabetes, while GABA supplementation may help protect the brain, reduce insomnia, and lower blood pressure.

According to the International Society of Sports Nutrition, beta-alanine supplementation may help improve exercise performance and reduce muscle fatigue.

 However, it may cause a tingling sensation in some people. This can be avoided by taking a lower dose (1.6 grams) or choosing a sustained-release supplement. Since this supplement only contains 400 milligrams of beta-alanine, it’s less likely to cause a tingling sensation.

This supplement is third-party tested and manufactured in a CGMP-compliant facility, ensuring that you receive a high-quality supplement.

Best Gummy

Juvenon BloodFlow-7 Gummies

$38.21 at Amazon
$44.95Now 15% Off
Buy on Amazon $38.21

Pros

  • Contains Nitrosigine
  • Vegan-friendly
  • Contains resveratrol
  • Third-party tested
  • Manufactured in FDA-registered facility

Cons

  • 6 grams of added sugar
  • Limited buying options

Key Specs

  • Form: Gummy
  • NO-boosting ingredients: Nitrosigine (500 mg)
  • Other ingredients of note: Resveratrol (30 mg)
  • Serving size: Two gummies, once daily
  • Third-party tested: Yes
We chose Juvenon BloodFlow-7 Gummies as the best gummy nitric oxide booster because they contain Nitrosigine and are gelatin-free, making them vegan-friendly. Nitrosigine is a patented type of arginine that’s bound to silicon and stabilized by inositol, a type of sugar that plays a role in cell communication. This makes it more bioavailable than other forms of arginine, which may enhance its effects. It’s been shown to increase levels of arginine in the blood for up to six hours. Studies also show that taking Nitrosigine increases energy levels before exercise and increases hyperemia, or higher blood flow, after exercise.

This supplement also contains resveratrol, an antioxidant found in fruits like grapes and blueberries, which has been shown to help reduce inflammation.

 Resveratrol may also help reduce risk factors for certain chronic diseases. A meta-analysis of randomized controlled trials showed that resveratrol supplementation may reduce blood pressure in people with type 2 diabetes. It was also shown to significantly reduce LDL (“bad”) cholesterol and HbA1C (a measure of blood sugar levels for the past three months).

Juvenon BloodFlow-7 gummies are produced in a U.S. Food and Drug Administration (FDA)–registered facility and are third-party tested to ensure purity and potency. They also have a 60-day unconditional guarantee, within which time you can get a refund of the purchase price of the gummies if they didn’t work for you or if you decide you no longer want to use them. One downside of these gummies, however, is that they contain 6 grams of added sugar, which could be an issue for those trying to minimize their sugar intake.

Best Budget

Double Wood Supplements Nitric Oxide Booster

$16.15 at Amazon
$19.95Now 19% Off
Buy on Amazon $16.15

Pros

  • Most affordable on our list
  • Contains Nitrosigine, L-citrulline
  • Vegan-friendly
  • Third-party tested
  • Certificate of analysis available
  • Made in a CGMP-certified facility

Cons

  • One dose is three capsules
  • Lower dose of citrulline, arginine

Key Specs

  • Form: Capsule
  • NO-boosting ingredients: Nitrosigine (500 mg), L-citrulline (500 mg), arginine AKG (250 mg), arginine HCl (250 mg)
  • Serving size: Three capsules, once daily
  • Third-party tested: Yes
Double Wood Supplements Nitric Oxide Booster is the least expensive option on our list (at 33 cents a dose), but it still contains high-quality ingredients like Nitrosigine and L-citrulline (as well as L-arginine and arginine AKG), both of which have been shown in research to significantly boost NO production.

 These capsules are also vegan-friendly, so people following any type of diet can enjoy the savings.

We appreciate that all Double Woods Supplements products are third-party tested and manufactured in a CGMP-compliant facility, and also that publicly available certificates of analysis are available that show exactly what is in each supplement. Double Wood Supplements offers a 30-day money-back guarantee on the first bottle of any supplement you buy. If you’re unsatisfied with the product, you can contact them within 30 days, and they will refund the purchase price of one supplement bottle.

One downside of this supplement is that a dose is three capsules, which could be burdensome for some, although the capsules are relatively small and easy to swallow. This supplement also contains lower amounts of arginine and citrulline than other NO supplements. If you want to increase your dosage of citrulline and arginine by taking this supplement more than the recommended daily amount, speak with your healthcare provider to ensure that there are no contraindications for doing so.

Best for Muscle Growth

CON-CRĒT Creatine HCl + Nitric

$29.97 at Walmart
$31.99Now 6% Off
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Pros

  • Contains creatine
  • Contains citrulline and beet powder
  • Gluten-free
  • No sugar or artificial colors, flavors, or sweeteners
  • Manufactured in a CGMP-compliant facility

Cons

  • Not NSF Certified for Sport
  • Multiple servings per day needed

Key Specs

  • Form: Powder
  • NO-boosting ingredients: Citrulline HCl (750 mg), organic beet root powder (2,000 mg)
  • Other notable ingredients: Creatine (750 mg)
  • Serving size: One scoop (6.05 grams), one to two times daily for general health, or two to three times daily for intense exercise
  • Third-party tested: No
We chose CON-CRĒT Creatine HCl + Nitric Oxide as the best NO-boosting supplement for muscle growth because, in addition to beet powder and citrulline, which boost NO production and enhance athletic performance, it also contains creatine.

Creatine is one of the most well-studied sports supplements. A 2022 review of the effects of creatine supplementation on muscle growth found that creatine supplementation was an effective way to promote muscle growth in young, healthy, physically active people.

 This NO-booster contains no sugar or calories and is free of artificial colors, flavors, and sweeteners. Its short ingredient list may be appealing to those looking for a supplement without a lot of additives.

One downside of this supplement is that although it’s manufactured in a CGMP-compliant facility, it isn’t third-party tested by NSF Certified for Sport like the other CON-CRĒT creatine supplements. However, given that CON-CRĒT has many other products that are third-party tested, we still feel comfortable recommending this one.

Best for Heart Health

Pure Encapsulations Nitric Oxide Ultra

$75 at Amazon
Buy on Amazon $75

Pros

  • Contains cranberry, grape seed extract
  • Contains L-citrulline
  • Vegetarian-friendly
  • Hypoallergenic
  • Third-party tested
  • Manufactured in a CGMP-compliant facility

Cons

  • Low dose of L-citrulline
  • Effectiveness and results vary

Key Specs

  • Form: Capsule
  • NO-boosting ingredients: L-citrulline (1,000 mg)
  • Other notable ingredients: Cranberry fruit extract and grape seed extract (382 mg)
  • Serving size: Two capsules, one to two times daily
  • Third-party tested: Yes
Pure Encapsulations Nitric Oxide Ultra earned our pick for the best NO-boosting supplement for heart health because, in addition to containing L-citrulline, which boosts NO production and can reduce blood pressure, it also contains cranberry and grape seed extract — antioxidants that may help with blood-vessel dilation.

A study published in 2022 that looked at the effects of cranberry on blood vessel function found that taking a cranberry supplement daily increased blood vessel dilation, which improved overall blood vessel function.

 And a study published in 2021 found that daily grape seed extract supplementation was associated with better blood vessel function and improved blood pressure. It also lowered perceived stress.

 Overall, the addition of these two ingredients to the supplement may improve its heart-health benefits.

We also like that this supplement is hypoallergenic and free of allergens like wheat, soy, dairy, eggs, tree nuts, peanuts, and gluten. It’s also free of artificial colors, flavors, sweeteners, coatings and shellacs, genetically modified organisms, and unnecessary binders, fillers, and preservatives. Overall, it’s a supplement that appeals to a wide range of dietary needs. Finally, third-party labs like Eurofins and Advanced Laboratories test all Pure Encapsulations products, and they are also produced in a CGMP-compliant facility, ensuring the highest quality.

There are a couple of downsides to this product. First, it contains a relatively low dose of L-citrulline. If you plan on taking more of this product to reach the effective dose of 6,000 milligrams to lower blood pressure, speak with your doctor to ensure that doing so is safe for you.

 It’s also worth noting that our research found that the effectiveness and results of this supplement can vary by person, so keep in mind that, as with any supplement, what’s effective for one person may not be effective for another.

Best Vegan

Jarrow Formulas Arginine-Citrulline Sustain

$42.36 at Amazon
Buy on Amazon $42.36

Pros

  • Vegan-friendly
  • Third-party tested
  • Affordable vegan formula
  • Contains L-arginine, L-citrulline
  • Free of common allergens

Cons

  • Tablets may crumble if not stored in original bottle
  • Results vary

Key Specs

  • Form: Tablet
  • NO-boosting ingredients: L-arginine (500 mg), L-citrulline (500 mg)
  • Serving size: Two tablets, one to two times daily
  • Third-party tested: Yes

We chose Jarrow Formulas Arginine-Citrulline Sustain as the best vegan NO-boosting supplement because it was one of the few vegan formulas that is both affordable and third-party tested to ensure purity and potency. At around 40 cents a dose, this supplement was significantly less expensive than some of the other vegan NO-boosters we reviewed. We also liked that this supplement is free of common allergens like wheat, gluten, soy, dairy, egg, fish, shellfish, peanuts, tree nuts, and sesame, making it a good choice for those with food sensitivities.

The two NO-boosters in this supplement are L-arginine and L-citrulline. While it contains relatively low doses of both, its only other ingredient is a small amount of vitamin C, so you could speak with your healthcare provider about taking a higher dose of this supplement, if necessary.

Best for Erectile Dysfunction

Innosupps Nitro Wood

$19.99 at Amazon
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Pros

  • Contains French maritime pine bark extract
  • Vegan-friendly
  • No artificial sweeteners, additives
  • Third-party tested
  • Manufactured in a CGMP-compliant facility

Cons

  • May cause “niacin flush”
  • Does not contain L-arginine or L-citrulline

Key Specs

  • Form: Capsule
  • NO-boosting ingredients: Beetroot powder (200 mg)
  • Other ingredients: French maritime pine bark extract (200 mg)
  • Serving size: Two capsules
  • Third-party tested: Yes
Innosupps Nitro Wood earned our pick as the best NO-booster for erectile dysfunction because, in addition to beetroot powder, a known NO-booster, it also contains French maritime pine bark extract. A small study of people with erectile dysfunction found that supplementing with French maritime pine bark extract led to significant improvements in erectile function.

 In addition, a meta-analysis of three studies showed similar potential benefits for erectile disfunction symptoms.

This supplement is third-party tested and produced in a CGMP-compliant facility. Plus, Innosupps has a 30-day money-back guarantee. If you’re unsatisfied with the product, they will refund your money if you initiate a return within 30 days of receiving it.

One thing to note about this supplement is that it contains 10 milligrams of niacin. This may cause “niacin flush.” While niacin flush typically occurs with doses of 30 to 50 milligrams of niacin, sensitive individuals may experience it at lower doses. When a person experiences niacin flush, the skin on their face, arms, and chest becomes red, accompanied by a burning, tingling, and itching sensation. In serious cases, it can be accompanied by headaches, dizziness, and a decrease in blood pressure.

Comparison Table

Best For
Serving Size
NO-boosting ingredients
Third-party tested
Blonyx Beet-It Sport Nitrate 400
Liquid
1 to 2 single-serving bottles
Nitrates from beet juice (400 mg)
Yes
Buy Now $49.95
Type Zero Clean Stim-Free Preworkout + Nitric Oxide Booster
Powder
1 scoop
L-citrulline malate (5,000 mg), arginine AKG (2,000 mg), beet root extract (1,000 mg)
Yes
Buy Now $32.95
Juvenon BloodFlow-7 Gummies
Gummy
2 gummies
Nitrosigine (500 mg)
Yes
Buy Now $38.21
Double Wood Supplements Nitric Oxide Booster
Budget
3 capsules
Nitrosigine (500 mg), L-citrulline (500 mg), arginine AKG (250 mg), arginine HCl (250 mg)
Yes
Buy Now $16.15
CON-CRĒT Creatine HCl + Nitric Oxide
Muscle growth
1 scoop
Citrulline HCl (750 mg), organic beet root powder (2,000 mg)
No
Buy Now $29.97
Pure Encapsulations Nitric Oxide Ultra
Heart health
2 capsules
L-citrulline (1,000 mg)
Yes
Buy Now $75
Jarrow Formulas Arginine-Citrulline Sustain
Vegan
2 tablets
L-arginine (500 mg), L-citrulline (500 mg)
Yes
Buy Now $42.36
Innosupps Nitro Wood
Erectile dysfunction
2 capsules
Beetroot powder (200 mg)
Yes
Buy Now $19.99

How We Chose the Best Nitric Oxide–Boosting Supplements

Our selection process for the best nitric oxide boosters involved thorough research and criteria designed to prioritize safety, effectiveness, and value. We reviewed over 25 popular NO boosters on the market and compared key factors such as ingredient quality, third-party testing, and price per serving. We also consulted with Kaitlyn Comeau, RD, owner of KC Gaining Wellness in Nova Scotia, Canada, and Leah Reitmayer Murnane, RD, owner of Lettuce Eat Dessert in Fayetteville, North Carolina.

Overall, we chose products that meet rigorous quality standards, ensuring that only reputable brands with transparent sourcing and labeling made it onto our final list. While we did include one supplement that was not third-party tested, that company has many other products that are third-party tested. We felt confident that being produced in the same facilities as these other products meant it was a high-quality supplement that we could recommend. As a registered dietitian myself, I’m qualified to evaluate the quality and effectiveness of supplements. I also interviewed two fellow registered dietitians to gain insight into NO boosters’ potential benefits and uses, especially for athletic performance and heart health.

What to Look for When Buying Nitric Oxide–Boosting Supplements

When choosing a nitric oxide-boosting supplement, there are a few things to consider to ensure you’re getting a safe, effective, and high-quality product:

  • Ingredients: Look for NO-boosting ingredients like L-arginine, L-citrulline, and beetroot extract, as these are the most effective in promoting NO production. Some products also contain supporting ingredients like antioxidants that may further support circulation and energy levels.
  • Third-party testing: Choose products that are third-party tested or have certifications like NSF-Certified for Sport to ensure they’re free of banned substances and contain only what’s listed on the label.
  • Form: NO boosters are available in many different forms, including capsules, liquids, and powders. Pick the one that best suits your lifestyle and preferences.
  • Price: Compare prices and keep the cost per serving in mind to ensure you’re getting good value for money.
  • Brand reputation: Look for brands with a good reputation for transparency and quality. Check customer reviews to see what real-life supplement users think of the product.
  • Dose: To improve athletic performance, 6,000 to 8,000 milligrams of L-citrulline and 3,000 to 6,000 milligrams of L-arginine have been recommended, but individual dosing may vary.

     Still, it’s worth noting that most high-dose citrulline and arginine supplements on the market are not third-party tested and contain other ingredients as part of a pre-workout formula. Since not everyone is looking for a pre-workout supplement, these products may not be appropriate. If you’re using a supplement containing just citrulline or arginine, you may be able to increase your dose to reach the recommended daily dose of these nutrients, but shorter term use is recommended, as longer use safety isn’t as well established.

     It’s important to speak with your doctor before doing so, as NO-boosters are not safe in certain situations, such as if you’re taking a blood pressure-lowering medication or have kidney issues.

What Are the Benefits of Taking a Nitric Oxide–Boosting Supplement?

According to Comeau, nitric oxide boosters can support healthy blood flow, boost exercise performance, and promote heart health by helping blood vessels relax and lowering blood pressure. She adds that some studies also suggest they may benefit brain health by improving blood flow and brain function.

 Overall, supplementation to increase NO production is an emerging and evolving area of research, and these products are not part of conventional clinical guidelines at this time.
NO boosters like L-citrulline and beetroot powder/juice may lower blood pressure. A 2019 systematic review and meta-analysis found that L-citrulline supplementation may lower systolic blood pressure (the top number). When taken in doses of 6,000 mg or more per day, a reduction in diastolic blood pressure (the bottom number) was also observed.

Beetroot juice is also associated with lower blood pressure. A 2017 systematic review and meta-analysis found that supplementation with beetroot juice was associated with significantly lower systolic and diastolic blood pressure numbers.

 Finally, a 2022 systematic review and meta-analysis found that L-arginine supplementation may be effective at reducing blood pressure.

However, although NO boosters may reduce blood pressure, they’re not part of conventional hypertension management guidelines and would be more of a complementary approach. It’s also vital to include evidence-based lifestyle changes like watching your salt intake, exercising, and getting enough sleep.

What Are the Downsides of Taking a Nitric Oxide–Boosting Supplement?

According to Reitmayer Murnane, nitric oxide boosters may cause gastrointestinal issues such as nausea, stomach pain, and bloating. They may also cause a drop in blood pressure, she adds. This is why it’s important not to take NO boosters if you’re already taking a blood pressure-lowering medication. Since NO boosters can also lower blood pressure, the combination may lead to dangerously low blood pressure.

It’s also recommended that those with kidney issues have a discussion with their doctor or nephrologist before starting these supplements, as they may impact kidney function and structure with long term use.

 Common side effects of NO boosters include bloating, mild headaches, and stomach upset, says Comeau. “Since long-term risks aren’t fully known,” she explains, “it’s wise to use NO boosters with caution, especially for those with preexisting health conditions.”

FAQ

What are nitric oxide–boosting supplements used for?
“NO boosters may be beneficial for endurance athletes or individuals looking to decrease fatigue during exercise,” says Murnane. They may be helpful in these situations because NO can help improve blood flow, she explains. “It also helps increase blood oxygen delivery to the muscles,” she adds, “which can help increase performance and endurance in athletes, as well as overall health.”
“For athletes, taking NO boosters 30 minutes before exercise is ideal,” says Comeau, “while nonathletes may benefit from a morning dose to support daily energy and circulation.” She recommends following the manufacturer’s recommended dosage and staying consistent to allow the benefits to build over time.
“Most users report feeling the effects within 30 to 60 minutes of taking NO supplements,” says Comeau, “especially when used for exercise.” For ongoing and longer-term benefits, such as enhanced blood flow or brain support, Comeau notes that it may take several days to a few weeks of consistent use to notice changes.
“NO boosters can interact with blood pressure medications and blood thinners,” says Comeau, “so it’s important to consult with a physician or pharmacist before use, particularly if you’re taking other medications.”

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Sarah Glinski, RD

Author

Sarah is a registered dietitian and accomplished health and nutrition writer known for her expertise in crafting engaging content. She received dual bachelor’s degrees in nutrition and biology with distinction from the University of Alberta. She started her career in 2018 as a clinical dietitian and has experience in several clinical areas, including weight management, diabetes, kidney disease, oncology, gut health, and intuitive eating.

In 2022, Sarah took her wealth of clinical experience and transitioned to freelance writing. She has contributed to outlets like Forbes Health, Well+Good, Livestrong, Yahoo!, and PS, and has written about topics ranging from mental health to gut health to diabetes care. Her goal as a writer is to convey complex health information in an easy-to-understand and engaging way.

Sarah is dedicated to simplifying complex health information so people can make informed decisions regarding their health. She currently lives in British Columbia, Canada, where she enjoys reading or crocheting in the company of her husband and two cats.

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Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
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