Recognizing the Signs of Mild Cognitive Impairment Due to Alzheimer’s Disease

Recognizing the Signs of Mild Cognitive Impairment Due to Early Alzheimer’s Disease

Almost everyone can relate to misplacing their car keys or forgetting the name of an actor. It’s a type of memory lapse that’s not unusual and can become even more common with age.

In other cases, though, these incidents can be a sign of mild cognitive impairment (MCI), which can develop into Alzheimer’s disease or another type of dementia.

“As we get older, our bodies and our brains age,” says Monica Moreno, senior director of care and support at the Alzheimer’s Association. That’s why it can be easy to regard problems with memory or reasoning as a normal part of aging. “But there are some symptoms or warning signs that may indicate something more serious is going on,” she says.

MCI and Alzheimer’s: What’s Happening in the Brain

Mild cognitive impairment is characterized by the wearing down of the myelin sheaths that surround neurons — nerve cells that are responsible for sending and receiving messages between the brain and other areas of the body.

As the protective myelin erodes, communication between neurons slows down, which, in turn, can interfere with the ability to retrieve memories and information. That’s typically the reason for those tip-of-the-tongue moments that are familiar to many people as they head toward their 60s and beyond.

Mild cognitive impairment can remain stable or — for 10 to 15 percent of people diagnosed with the condition — progress to Alzheimer’s disease or some other type of dementia.

 In this case, the damage to the neurons is due to abnormalities in certain naturally occuring proteins in the brain (amyloid and tau). Neurons eventually stop working altogether, and the connections between them break down.
In the early stages of both mild cognitive impairment and Alzheimer’s, the damaged neurons are usually located in the hippocampus, the area of the brain involved in memory storage. Later on, the neurons elsewhere in the cortex — areas responsible for language, math, reasoning, social behavior, and visual-spatial ability — can also be affected.

Early Signs of MCI Due to Alzheimer’s

People with Alzheimer’s disease will often experience more severe memory loss than people who are aging normally. This degree of memory loss leaves them “amnestic,” or unable to remember new information. They typically repeat, ask questions over and over, and rapidly forget what was said between questions.

Other symptoms are likely to set in, too. These include having difficulty carrying on a conversation or using the wrong name for an object, being unsure, and not understanding explanations, problems, and situations easily.

 “When we test [a person for Alzheimer’s disease], we test whether they have memory impairment plus impairment in another domain,” says Victoria Leavitt, PhD, a clinical neuropsychologist at Columbia University in New York City.

Among the signs of Alzheimer’s are:

Memory Loss That Interferes With Normal Functioning

One of the most common (and earliest) signs of Alzheimer’s disease is an inability to remember information, particularly new information. Over time, this memory loss can start to take a toll on daily life.

A person in the early stages of Alzheimer’s may forget to go to appointments, take medications, or pay bills or not remember how to get to a familiar location. They may forget what they need at home and buy the wrong things. They may make errors driving or get lost.

Difficulty Doing Familiar Tasks

When Moreno asks people with Alzheimer’s what prompted them to see a doctor, they often say they’ve been having trouble doing activities that they did their whole life. “Tasks that had been so normal and easy for them were now becoming more and more difficult,” she says.

For example, “I met a woman who was a vice president of a bank, and one day she was trying to help her grandsons with their homework, and she couldn’t do a simple math problem,” says Moreno. “Then there was an award-winning chef who suddenly forgot how to make an omelet one morning.” In each case, tasks that had been easy for that particular person had suddenly become impossible.

“If there’s something that you’ve done your whole life, and now all of a sudden you’re being challenged with doing it, that can be an indication that something more serious is going on,” she says.

Trouble Speaking or Finding the Right Words

Dr. Leavitt says that along with memory loss, people with mild cognitive impairment typically have trouble with language. “It comes across as, ‘I can’t get the words out,’ or ‘Her name is on the tip of my tongue,’” she says. “It’s something that’s very common, but [in people with Alzheimer’s], it’s more severe.”

People with mild cognitive impairment due to Alzheimer’s may also have trouble keeping up a conversation. They may stop in the middle of a sentence and lose their train of thought, for example, or repeat themselves. They can also have trouble retrieving words from their brain’s storehouse of information, which is known as “lexical access.”

“Think of your brain as a big warehouse,” says Leavitt. “You’ve got all these little forklifts, and you send them off to aisle 9, row 47. That requires coordination among areas of your brain to go to the right place, grab the information, and bring it out. … When it falls apart a little bit, that’s normal, healthy aging. But when that starts to fall apart a lot, that tends to be a signifier of Alzheimer’s.”

Other signs of mild cognitive impairment or Alzheimer’s include difficulty keeping track of time and dates, trouble judging distances, withdrawal from family and friends, and poor decision-making (such as overspending) — all of which can make daily life challenging and even unsafe.

When to See a Doctor

Moreno encourages people to see a doctor if they (or a loved one) notice even one of the symptoms of mild cognitive impairment or Alzheimer’s. “You shouldn’t wait to experience all the signs,” she says.

A general doctor, neurologist, geriatrician, or psychiatrist can perform tests to evaluate cognitive functioning. The ones that are most often used include:

  • Montreal Cognitive Assessment (MoCA), which involves memorizing a short list of words, naming certain objects, and copying shapes
  • Mini-Mental State Exam (MMSE), which requires counting backward, identifying objects, and stating other facts, such as the date
  • Mini-Cog Screening, which involves memorizing and recalling words and drawing a picture of a clock with the hands pointing to a specific time

A neurologist can also order blood work and brain scans, such as a CT scan or MRI, to evaluate the structure of the brain and find possible contributing causes.

 A PET scan of the brain can reveal the presence of amyloid, and a spinal tap (less commonly done), in which fluid is drawn from the spinal cord, can reveal the presence of amyloid and tau.

It’s important to get a diagnosis as soon as possible, because the medications that slow the progression of the disease work best when used early. It’s never too early to get help for distressing symptoms of memory loss, functional problems, or neuropsychiatric problems, such as anxiety, apathy, depression, and irritability. By the same token, don’t avoid diagnosis and treatment because you think it’s too late.

“It can be hard to face the reality of decline that [you or] a loved one is experiencing, [but] you have to put safety above everything else,” says Leavitt.

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. How Memory and Thinking Ability Change With Age. Harvard Health Publishing. August 30, 2017.
  2. Memory Problems, Forgetfulness, and Aging. National Institute on Aging. November 22, 2023.
  3. Mild Cognitive Impairment (MCI). Alzheimer’s Association.
  4. What Happens to the Brain in Alzheimer’s Disease? National Institute on Aging. January 19, 2024.
  5. 10 Early Signs and Symptoms of Alzheimer’s and Dementia. Alzheimer’s Association.
  6. Cognitive Test. Cleveland Clinic. January 14, 2025.
  7. How Is Alzheimer’s Disease Diagnosed? National Institute on Aging. December 8, 2022.
  8. Earlier Diagnosis. Alzheimer’s Association.
Jessica-Baity-bio

Jessica Baity, MD

Medical Reviewer

Jessica Baity, MD, is a board-certified neurologist practicing in southern Louisiana. She cares for a variety of patients in all fields of neurology, including epilepsy, headache, ...

Maria Masters

Maria Masters

Author

Maria Masters is a contributing editor and writer for Everyday Health and What to Expect, and she has held positions at Men's Health and Family Circle. Her work has appeared in Hea...