Celebrities on Mounjaro, Zepbound, Wegovy, Ozempic, and Other GLP-1 Weight Loss Drugs
Weight ManagementWeight Loss

15 Celebrities Who’ve Taken GLP-1 Weight Loss Drugs

Discover what star athletes and actors on Zepbound, Mounjaro, Ozempic, and Wegovy have to say about their experiences on these game-changing medications.
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Updated on December 30, 2025
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What Celebrities Have Said About Taking GLP-1s

These celebrities are reducing the stigma around GLP-1s.

GLP-1 medications are no longer Hollywood’s “worst kept secret.” From award-winning actors to sports icons, more and more celebrities are sharing how GLP-1 drugs like Ozempic, Wegovy, Zepbound, and Mounjaro have shaped their weight loss experiences.

Their honesty is helping shift the conversation away from shame and toward real talk about managing weight and the impact this can have on all aspects of life, including physical and mental health.

Here are 15 well-known figures who’ve shared their GLP‑1 journeys — what worked, what didn’t, and how it’s changed them.

1

Oprah Winfrey

Oprah Winfrey
In March 2024, Winfrey hosted a prime-time show on ABC titled An Oprah Special: Shame, Blame, and the Weight Loss Revolution, in which she talked about all things GLP-1 and her personal success on these drugs.

“In my entire life, I never dreamed that we would be talking about medicines that are providing hope for people like me who have struggled for years with being overweight or with obesity,” she told People magazine.

But she didn’t reveal one setback she’d had on her health journey. In a later interview with People, published in December 2025, Winfrey revealed that just six months after starting GLP-1s, she’d decided to see if she could “beat the medication” by stopping injections. Her goal was to prove she could maintain the weight loss on her own.

Over the next 12 months, however, she regained about 20 pounds and had valuable new insight into GLP-1 use. “It’s going to be a lifetime thing,” Winfrey said. “I’m on high blood pressure medication, and if I go off the high blood pressure medication, my blood pressure is going to go up. The same is true, I now realized, with these medications. I’ve proven to myself I need it.”

GLP-1s aren't just for the stars. Explore our recommendations for the best ways to buy weight loss medications online.

2

Serena Williams

Serena Williams
The tennis legend Serena Williams revealed in summer 2025 that after having her second child she lost 31 pounds (lb) by using the GLP‑1 drug Zepbound (tirzepatide). In an interview with People, she emphasized that even after extensive sports training and healthy eating, she felt stuck.

“I knew my body was missing something it needed. For me, the answer was GLP-1s,” Williams said.

As a paid ambassador for Ro, a telehealth GLP-1 provider, she’s using her platform to emphasize that using a weight loss drug “isn’t a shortcut, it’s healthcare.” And that the drug is part of an overall plan that also includes a healthy diet and exercise.

“I feel like I have a lot of energy and it’s great. I just feel pretty good about it,” said Williams.

3

Rebel Wilson

Rebel Wilson
The star of Pitch Perfect and The Hustle shared that she used Ozempic for a period of time to maintain the weight loss she experienced when she made 2020 her “Year of Health” and lost 77 lb.

“Someone like me could have a bottomless appetite for sweets, so I think those drugs can be good,” she later said in a 2024 interview. Wilson added that she no longer used GLP-1s and was happy with her current “still curvy and solid” weight.

“I feel strongly that young women shouldn’t try to obsess over looking like Victoria’s Secret models — they should just look like themselves. … I know that my relationship with food is complicated,” she also said.

4

Whoopi Goldberg

Whoopi Goldberg
In 2024 the actor and talk show personality revealed to her cohosts on The View that she took Mounjaro (tirzepatide) to lose a significant amount of weight. “I will tell you, I weighed almost 300 lb when I made [the 2022 film] Till. I had taken all those steroids, I was on all this stuff, and one of the things that’s helped me drop the weight was the Mounjaro. That’s what I used.”

Goldberg also discussed how all the constant chatter around people’s appearance can be harmful — and how everyone should be nicer to themselves and others. “Maybe the key is to stop judging everybody. Maybe that’s the key,” she said.

5

Charles Barkley

Charles Barkley

The former professional basketball star said he lost around 60 lb by taking Mounjaro, in addition to maintaining a healthy diet and exercise.

“It's been great. I'm starting to feel like a human being,” Barkley revealed on The Pat McAfee Show, according to a post on the social platform X. Describing his experience, he said, “It's been amazing,” and added that his ultimate goal is to live longer. “I started at 352, and I’m down to 290,” with an ultimate goal of 270, he said.

6

Kathy Bates

Kathy Bates
The Oscar winner Kathy Bates has lost 100 lb over the past seven years — 80 through lifestyle changes and the final 20 with Ozempic. The journey began after a type 2 diabetes diagnosis that inspired her to “get serious about her health,” she said in a 2024 interview.

“It was hard work … especially during the pandemic,” said Bates.

The actor also shared her plans to work out more with activities like walking and Pilates in order to maintain her weight loss.

7

Meghan Trainor

Megan Trainor

The “All About That Bass” singer and her husband, the actor Daryl Sabara, took the lowest drug dose and combined the shots with exercise and balanced meals in a weight loss journey made for two.

The Grammy winner took to social media to respond to people who kept commenting on her transformation after her appearance at Billboard’s 2025 Women in Music Awards.

"No, I don’t look like I did 10 years ago. I’ve been on a journey to be the healthiest, strongest version of myself for my kids and for me. I’ve worked with a dietitian, made huge lifestyle changes, started exercising with a trainer, and yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy. And I’m so glad I did because I feel great,” Trainor wrote on Instagram.

8

Billie Jean King

Billie Jean King

Ten-time Grand Slam winner Billie Jean King spoke to actor Julia Louis-Dreyfus on the podcast Wiser Than Me about her decision to try a GLP-1.

“I’m a binge eater,” said the 80-year-old King. “Every morning, I wake up, I tell myself I have an eating disorder. … It’s interesting with the new injections, you know, with the Ozempics of the world. It’s very interesting because my doctor wants me to try it.”

She later revealed that she had already started on the medication and hoped that it would help quiet the food noise in her mind.

9

Jim Gaffigan

Jim Gaffigan
The comedian Jim Gaffigan, author of the bestselling book Dad Is Fat, shared in an interview with People that after his weight reached 270 pounds, he tried Mounjaro and lost 50 pounds, crediting the drug for helping him feel better, lighter, and more alive. “I’m just grateful because it’s such a better life,” he said.

Gaffigan is puzzled by the stigma around the medication, which is part of the reason he wanted to talk about it. “I don’t think there’s anything wrong with it. … It’s just whatever gets you through,” he said.

10

Claudia Oshry

Claudia Oshry
For Oshry, a comedian, the cohost of the podcast The Toast, and the creator of the popular Instagram account @girlwithnojob, taking a GLP-1 was a no-brainer. She told listeners on her podcast, “You thought they were going to make a weight loss drug and I wasn't going to take it?”

She joked at the time that she would regain the weight because her Ozempic use wasn’t permanent. In a 2024 interview she revealed that she’d stopped taking the injections when she and her husband, Ben Soffer, decided to have kids.

11

Elon Musk

Elon Musk
When one fan asked the billionaire owner of X in 2022, “What’s your secret? You look awesome, fit, ripped, and healthy. Lifting weights? Eating healthy?” Musk credited fasting and Wegovy for his transformation.

The Tesla and SpaceX chief has said he wants to make the drug more accessible to all Americans, posting on X in 2024 that “nothing would do more to improve the health, lifespan, and quality of life for Americans” than making GLP-1s “super low cost to the public.”

12

Rosie O’Donnell

Rosie ODonnell
The actor and comedian first revealed on TikTok that she had shed 10 lb on Mounjaro, and then followed it up with another post about how she lost 15 lb on the lowest dose.

Two years later, O’Donnell is still “shocked” by the transformation of her body. In addition to staying on the weight loss drugs, the actor eats less sugar, drinks water, and tries to move more.

13

Tracy Morgan

Tracy Morgan
The comedian and former star of The Last O.G. made headlines when he shared on Today in 2023 that he was taking Ozempic. “That’s how this weight got lost. … I went and got a prescription and I got Ozempic. I'm not letting it go,” he said.

Morgan has continued to praise the drug, saying, “Ozempic did great by me and I was glad to use it. I take Ozempic every Thursday,” as E! News reported. “It cuts my appetite in half.”

14

Chelsea Handler

Chelsea Hander

Surprisingly, the comedian didn’t know she was taking Ozempic when she first received a prescription, she said in an interview on the Call Her Daddy podcast. “My anti-aging doctor just hands it out to anybody,” Handler said. “I didn't even know I was on it.”

Apparently, that doctor suggested she take it “if you ever want to drop five pounds.” Handler later realized she was on the medication when she told a friend she was taking semaglutide, and her friend said it was Ozempic. Since then, Handler has stopped taking the medication.

15

Amy Schumer

Amy Schumer
Schumer’s first go-round with a GLP-1 didn’t go well. On a 2023 episode of the talk show Watch What Happens Live With Andy Cohen, the comedian and actor said she was “one of those people that felt so sick” taking Ozempic, which led her to discontinue it.

Three years later, in 2025, the actor reported she was having “a really good experience” taking a different weight loss drug, Mounjaro, along with hormone replacement therapy for perimenopause symptoms.

The Takeaway

  • Celebrities including Serena Williams and Charles Barkley have spoken openly about GLP-1 medications, helping reduce stigma.
  • These stars describe both the benefits and challenges of Ozempic, Wegovy, Zepbound, and Mounjaro.
  • Their stories show how GLP-1s can be transformative for some people but are not a permanent solution for others.
EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Getz S. Watch 'An Oprah Special: Shame, Blame and the Weight Loss Revolution' Monday, March 18. ABC. March 17, 2024.
  2. Leonard E. Oprah Winfrey Tackles Key Issues Around Weight Loss Drugs Amid Obesity Epidemic: 'Very Personal to Me’. People. March 18, 2024.
  3. Eileen Finan. Oprah Reveals She Stopped Using GLP-1s for 6 Months — and Shares Exactly What Happened (Exclusive). People. December 20, 2025.
  4. Serena Williams Reveals She Lost 31-Lbs. Using Weight-Loss Medication: ‘I Feel Great’ (Exclusive). People. August 21, 2025.
  5. Serena’s on Ro. Ro.
  6. Holohan M. Rebel Wilson shares how many hours a day she worked out during her ‘year of health’. Today. April 1, 2024.
  7. Agnew M. Rebel Wilson on Sex, Weight and Working with Sacha Baron Cohen. The Times. March 31, 2024.
  8. Rebel Wilson Reveals She Tried Ozempic for Weight Loss: 'Those Drugs Can Be Good'. People. March 31, 2024.
  9. Quinn D. Whoopi Goldberg Reveals She Used Weight Loss Medication Mounjaro After Hitting 300 Lbs.: ‘That’s a Lot of Me’. People. March 19, 2024.
  10. Goh RH. Celebrities Can't Lose Weight Without People Speculating They're on Ozempic. Serena Williams Is the Latest to Say She's Using a GLP-1. Business Insider. Aug 14, 2024.
  11. Kathy Bates Sets the Record Straight on Her Ozempic Use After Losing 100 Lbs.: ‘There’s Been a Lot of Talk’. People. October 9, 2024.
  12. Billie Jean King Says She Has ‘Taken a Few Injections’ to Quiet the Noise of Her Binge Eating Disorder. People. April 25, 2024.
  13. Comedian Jim Gaffigan Says He Lost 50 Lbs. with the Help of Mounjaro: ‘It’s Such a Better Life’ (Exclusive). People. November 14, 2024.
  14. Greene J. Claudia Oshry Says She's Been 'So Hungry' Since She Stopped Ozempic. People. March 6, 2024.
  15. Girl with No Job’s Claudia Oshry Is ‘Coming to Terms’ with Gaining Pregnancy Weight. Us Weekly. November 18, 2024.
  16. Elon Musk Rockets Weight-Loss Drug Into Public Eye. University of Colorado Anschutz. October 19, 2022.
  17. Smith R. Rosie O'Donnell Gives Weight Loss Update After Taking Diabetes Drug. Newsweek. March 16, 2023.
  18. Rosie O’Donnell Shows Off Dramatic Weight Loss After Using Mounjaro: ‘I Can’t Believe This Is Me’. People. May 24, 2025.
  19. Tracy Morgan opens up about childhood and life-altering choices. Today. August 14, 2023.
  20. Heller C. Tracy Morgan Sets the Record Straight on Experience With Ozempic . E! News. March 28, 2024.
  21. Chelsea Handler 'Didn't Know' She Was on Ozempic, Says Her Doctor 'Just Hands It Out to Anybody'. People. January 25, 2023.
  22. Amy Schumer Says She Tried Ozempic, Tells Others 'Lying' About It to 'Be Real' About Their Weight Loss. People. June 9, 2023.
  23. Amy Schumer Says She’s ‘Having a Really Good Experience’ with Weight Loss Drug After Past Fail: ‘Mounjaro’s Been Great’. People. March 23, 2025.
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Sean Hashmi, MD

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Castle Connolly Top Doctor, Member of American College of Lifestyle Medicine

Sean Hashmi, MD, is an experienced nephrologist and obesity medicine specialist based in Southern California. As the regional director for clinical nutrition and weight management at a prominent healthcare organization in Southern California, Dr. Hashmi oversees the development and implementation of cutting-edge nutritional programs and weight management strategies. With his innovative approach and unwavering commitment to providing evidence-based solutions, he is a highly sought-after speaker and a leader in his field.

Hashmi founded the nonprofit organization SelfPrinciple.org to provide accessible and accurate health, nutrition, and wellness information to the public. Through this platform, he shares the latest research findings, empowering individuals to make informed decisions about their well-being. Self Principle also supports children's education by providing scholarships, books, and supplies, so that students have the resources necessary to succeed academically and build a brighter future.

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Leslie Barrie

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Leslie Barrie is a health and nutrition writer and editor who loves running marathons and attempting to cook healthy meals for her family (even if they don’t always turn out as planned). She received her bachelor of science degree at UCLA and her master of science degree at the Columbia University Graduate School of Journalism. She has written and edited for publications like Health magazine, Seventeen, and Woman’s Day. Leslie won a Hearst Spotlight Award for her work in 2018 at Woman’s Day, and helped plan the Woman’s Day Red Dress Awards, an event honoring changemakers fighting to end heart disease in women.

When she isn’t writing, Leslie loves chasing her daughter and son around outside, going on family hikes, and starting her day with a big bowl of muesli.
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Becky Upham, MA

Becky Upham

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Becky Upham has worked throughout the health and wellness world for over 25 years. She's been a race director, a team recruiter for the Leukemia and Lymphoma Society, a salesperson for a major pharmaceutical company, a blogger for Moogfest, a communications manager for Mission Health, a fitness instructor, and a health coach.

Upham majored in English at the University of North Carolina and has a master's in English writing from Hollins University.

Upham enjoys teaching cycling classes, running, reading fiction, and making playlists.

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