What Is Milk Soy Protein Intolerance?

Updated on April 28, 2025
Milk soy protein intolerance (MSPI) is a temporary inability to digest the proteins in either cow’s milk, soy milk, or both, which typically affects infants. It’s also referred to as cow’s milk protein intolerance, and it’s different than a milk allergy.
Allergic colitis is the most common symptom of MSPI.
Allergic colitis can cause inconsolable crying and bloody stool in infants. While this can feel intense and be scary for parents, MSPI is treatable through dietary changes and is temporary in most children, often fading by the baby’s first birthday.