Libido Supplements: What Are They and Do They Work?

Note: The U.S. Food and Drug Administration (FDA) does not approve supplements for safety or effectiveness. Talk to a healthcare professional about whether a supplement is the right fit for your individual health, and about any potential drug interactions or safety concerns.
If you’re experiencing sexual dysfunction, such as a sluggish libido or difficulty getting an erection or having an orgasm, you may be tempted to try a supplement. However, it’s important to know that they can have limitations.
Many herbs are marketed as sex enhancers, but the evidence behind these claims is extremely thin, says Ikhlas Khan, PhD, the director of the National Center for Natural Products Research at the University of Mississippi. That doesn’t mean you shouldn’t try a supplement to potentially help your sex life, but “you should be educated as much as you can before you do,” Dr. Khan says. In addition, you should always talk to your healthcare provider, be it about supplementation or to address any underlying causes of sexual dysfunction.
Most studies on libido-boosting supplements are small and not well designed. That means that even the existing evidence should be viewed with caution, and more high-quality research is needed to better understand the effects of these products.
If you take other medications, be aware that some supplements can interfere with prescription drugs. Also, women who are pregnant or nursing should speak with their healthcare provider before taking supplements.
What Are Libido Supplements?
- Dehydroepiandrosterone (DHEA)
- Fenugreek
- Ginkgo biloba
- Ginseng
- Horny goat weed
- L-arginine
- Maca
- Tribulus
- Yohimbe
- Zinc
Types of Libido Supplements and the Science Behind Them
Walk into any pharmacy or health food store, and you’ll find plenty of supplement products promising to heat up your sex life. Most of these supplements have side effects, and many lack complete ingredient information on the packaging, such as how much of a particular herb or substance is in one capsule, gummy, or tincture. They also often fail to include where the herb or substance has been sourced from. This makes it even harder to evaluate them for quality and purity.
Among the many products claiming to correct sexual dysfunction, here are some of the most popular ones — and some of their purported benefits. However, keep in mind that research in this area is lacking and limited, and it’s best to discuss your concerns with your doctor first.
L-Arginine
However, this study “had a small sample size and focused on postmenopausal women, which limits generalizability,” says Angela Downey, MD, a family physician in private practice in Winnipeg, Manitoba.
Overall, “the research is promising in some areas but generally sparse,” she adds. “Many studies are small, short-term, or not done on women. There’s a big need for more diverse, high-quality trials before we can confidently say what works.”
- Gastrointestinal upset (stomach pain, bloating, diarrhea)
- Gout
- Headache
- Allergic response
- Airway inflammation or worsening of asthma symptoms
Yohimbe
However, “this study is a broad scientific review, not a clinical trial, so it’s more about mechanisms than real-world outcomes,” says Dr. Downey. “Also, lots of the research it cites is animal-based or outdated.”
- Heart attacks
- Seizures
- Anxiety
- Stomach problems
- Rapid heart rate
- Increased blood pressure
Be sure to speak with your healthcare provider before starting a yohimbe supplement, to make sure you are not at risk of any of these conditions or concerns, says Downey.
Ginkgo Biloba
That said, “these recent studies are mostly preclinical or theoretical,” says Downey. “Some small human trials suggest benefits, but results are mixed. Doses, durations, and populations studied differ a lot.”
- Headache
- Dizziness
- Upset stomach and constipation
- Heart palpitations
- Bleeding in those with a known bleeding risk
Downey also notes that ginkgo can interact with medications like blood thinners, so it’s important to talk to your doctor before you try this supplement to make sure it’s safe for you.
Ginseng
- Insomnia
- Skin rash, irritation, or burning
- Liver damage
- Low blood sugar
- Allergic reaction
Kava
- Headache
- Dizziness
- Digestive upset
- Headache
- Dry, flaky skin
Fenugreek
Overall, the evidence is mixed, highlighting the need for larger and more diverse clinical studies, Downey notes.
- Diarrhea and nausea
- Headache
- Dizziness
- Drop in blood sugar (when taken in large doses)
- Allergic reactions, such as hives anywhere on the body, or a tingling or itchy feeling in the mouth
Who May Want to Try Libido Supplements
Libido supplements may appeal to adults experiencing mild, occasional dips in sex drive, especially when those changes are linked to factors like stress or hormonal shifts (such as menopause or perimenopause), says Downey.
To choose a quality supplement, check the label for approvals from USP, NSF, or ConsumerLab. These indicate that the product has undergone third-party testing for quality and purity.
The Takeaway
- Many libido supplements are marketed with bold claims.
- Herbs like ginseng, fenugreek, L-arginine, and ginkgo biloba may offer some support for sexual function in some people, but studies on their effects are mixed and limited.
- Many ingredients in libido supplements may interact with common medications.
- It is vital to know the root cause of your sexual dysfunction before starting supplements.
- Speak with a healthcare provider before starting supplements, and check in again if your circumstances change while taking them.
Additional reporting by Meryl Davids Landau.
- Can Supplements Save Your Sex Life? Harvard Health Publishing. May 11, 2021.
- Low Libido (Low Sex Drive). Cleveland Clinic. April 21, 2025.
- Prescott H et al. Medicinal Plants/Herbal Supplements as Female Aphrodisiacs: Does Any Evidence Exist to Support Their Inclusion or Potential in The Treatment of FSD? Journal of Ethnopharmacology. April 6, 2020.
- Cui T et al. A Urologist’s Guide to Ingredients Found in Top-Selling Nutraceuticals for Men’s Sexual Health. Journal of Sexual Medicine. 2015.
- L-Arginine. Mayo Clinic. June 28, 2025.
- L-Arginine. MedlinePlus. February 2, 2025.
- Collins JK et al. Watermelon Consumption Increases Plasma Arginine Concentrations in Adults. Nutrition. March 2007.
- L-Arginine: Does It Lower Blood Pressure? Mayo Clinic. June 13, 2024.
- Nowacka A et al. Multifaceted Nature of Yohimbine — a Promising Therapeutic Potential or a Risk? International Journal of Molecular Sciences. November 29, 2024.
- Yohimbe. National Center for Complementary and Integrative Health. May 2025.
- Akaberi M et al. Ginkgo biloba: An updated review on pharmacological, ethnobotanical, and phytochemical studies. Pharmacological Research – Modern Chinese Medicine. December 2023.
- Gajjala SR et al. Premature Ejaculation: A Review. Indian Journal of Sexually Transmitted Diseases and AIDS. July 2014.
- Meston CM et al. Short- and Long-Term Effects of Ginkgo Biloba Extract on Sexual Dysfunction in Women. Archives of Sexual Behavior. February 15, 2008.
- Mashhadi ZN et al. A systematic review of clinical trials on Ginkgo (Ginkgo biloba) effectiveness on sexual function and its safety. Avicenna Journal of Phytomedicine. July 2021.
- Concerto C et al. A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications. Current Issues in Molecular Biology. July 25, 2022.
- Ginkgo. National Center for Complementary and Integrative Health. February 2025.
- Ginkgo. LiverTox. March 14, 2018.
- Li X et al. Ginseng and Ginseng Herbal Formulas for Symptomatic Management of Fatigue: A Systematic Review and Meta-Analysis. Journal of Integrative and Complementary Medicine. August 9, 2023.
- Ghorbani Z et al. The effect of ginseng on sexual dysfunction in menopausal women: a double-blind, randomized, controlled trial. Complementary Therapies in Medicine. August 2019.
- Lee HW et al. Using Ginseng for Menopausal Women’s Health Care: A Systematic Review of Randomized Placebo-Controlled Trials. Complementary Therapies in Clinical Practice. August 2022.
- Asian Ginseng. National Center for Complementary and Integrative Health. February 2025.
- Bian T et al. Kava as a Clinical Nutrient: Promises and Challenges. Nutrients. October 5, 2020.
- Kava. National Center for Complementary and Integrative Health. April 2025.
- Sarris J et al. Kava for the Treatment of Generalized Anxiety Disorder RCT: Analysis of Adverse Reactions, Liver Function, Addiction, and Sexual Effects. Phytotherapy Research. January 24, 2013.
- Fenugreek. National Center for Complementary and Integrative Health. February 2025.
- Thomas JV et al. Phytoestrogenic effect of fenugreek seed extract helps in ameliorating the leg pain and vasomotor symptoms in postmenopausal women: a randomized, double-blinded, placebo-controlled study. PharmaNutrition. December 2020.
- Rao A et al. Influence of a Specialized Trigonella foenum‐graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study. Phytotherapy Research. April 24, 2015.
- Koliji T et al. A Systematic Review of Herbal Medicines to Improve the Sexual Function of Menopausal Women. Journal of Herbmed Pharmacology. August 16, 2020.
- Herbal Supplements: Why to Check With a Healthcare Provider First. Cleveland Clinic. February 13, 2024.
- Complementary and Alternative Medicine. National Cancer Institute. October 31, 2024.

Kayli Anderson, RDN
Medical Reviewer
Kayli Anderson has over a decade of experience in nutrition, culinary education, and lifestyle medicine. She believes that eating well should be simple, pleasurable, and sustainable. Anderson has worked with clients from all walks of life, but she currently specializes in nutrition therapy and lifestyle medicine for women. She’s the founder of PlantBasedMavens.com, a hub for women to get evidence-based, practical, and woman-centered guidance on nutrition and cooking, hormone health, fertility, pregnancy, movement, mental well-being, nontoxic living, and more.
Anderson is board-certified in lifestyle medicine and serves as lead faculty of the American College of Lifestyle Medicine’s (ACLM) "Food as Medicine" course. She is past chair of the ACLM's registered dietitian member interest group, secretary of the women's health member interest group, and nutrition faculty for many of ACLM's other course offerings. She is the coauthor of the Plant-Based Nutrition Quick Start Guide and works with many of the leading organizations in nutrition and lifestyle medicine to develop nutrition content, recipes, and educational programs.
Anderson frequently speaks on the topics of women’s health and plant-based nutrition and has coauthored two lifestyle medicine textbooks, including the first one on women’s health, Improving Women's Health Across the Lifespan.
She received a master's degree in nutrition and physical performance and is certified as an exercise physiologist and intuitive eating counselor. She's a student of herbal medicine and women's integrative and functional medicine. She lives with her husband in the Colorado Rocky Mountains, where you’ll find her out on a trail or in her garden.

Diana Rodriguez
Author
Diana Rodriguez is a Kentucky-based health news writer. She is skilled at turning confusing doctor-speak and complex medical topics into understandable language for readers. She is a managing editor at Mayo Clinic and has written extensively for HealthDay.