MS Fatigue: 12 Ways to Fight It

12 Ways to Fight MS Fatigue

12 Ways to Fight MS Fatigue
Stocksy
Approximately 80 percent of people with multiple sclerosis (MS), a chronic autoimmune disease affecting the central nervous system, live with fatigue as a symptom.

“Other MS symptoms may come and go, but fatigue seems to be a constant, no matter what stage of MS they’re in,” says neurologist Jeffrey Cohen, MD, former director of Cleveland Clinic’s Mellen Center for Multiple Sclerosis Treatment and Research in Ohio.

How MS Fatigue Is Different

For many people living with MS, however, the word “fatigue” doesn’t quite capture the feeling of being completely depleted.

“I’ve always wished there was another term to describe MS fatigue,” says Michael Wentink, a writer with MS who lives in San Antonio, Texas, with his wife and two children. “When people hear fatigue as a symptom of MS, they often think, Oh, sure, I’m tired, too, but it’s not at all the same feeling,” he says.

“I remember what it was like to feel tired or fatigued before I had MS, and this is totally different,” says Wentink.

The kind of fatigue that comes with MS isn’t the kind that comes from exertion, Wentink explains: “I can wake up from a night of sleep and feel fatigued. After my shower and shaving, sometimes I literally need to go lie down on the bed for a little bit afterward to recover.”

What Causes MS Fatigue?

“There are many reasons someone with MS experiences fatigue,” Dr. Cohen says. “Some are directly related to MS, and some are not.”

Some of the types of fatigue that may affect people with MS are:

  • Indirect Fatigue Stress, trouble sleeping due to muscle spasms, side effects from medication, and depression that may go along with a chronic illness like MS can all cause fatigue. “Doctors should also rule out unrelated causes of fatigue, such as anemia or thyroid disease,” Cohen says.
  • Neurologic Fatigue “MS symptoms, like tremors, muscle weakness, and muscle spasms, use up a lot of energy and can lead to fatigue,” Cohen says. “Damage that has been sustained over time along nerve pathways can be aggravated by stress, activity, fever, and heat exposure. All of these factors contribute to MS fatigue.”
  • Autoimmune Fatigue “Persistent tiredness, or lassitude, is common in many autoimmune diseases and is probably the most common type of MS fatigue,” Cohen says. “It is very similar to the type of fatigue experienced in chronic fatigue syndrome.”
Perspectives
Portrait of a person
Cory
Living with multiple sclerosis
“For someone who doesn't experience fatigue truly, it's hard for them to understand. It's not sleepy. It's not tired. It's an inside exhaustion. You want to do things, but you mentally can't do it.”
Transcript Available

How to Reduce Your MS Fatigue

Is there anything you can do to reduce your fatigue? Experts say yes. Here are some tips for preserving your energy so you can get the most out of each day:

1. Work Closely With Your MS Healthcare Providers

Make and keep regular appointments with your doctor to assess whether your disease is under the best control possible and you’re receiving optimal MS treatment.

“In many cases, when MS is well-controlled, it can help in terms of fatigue levels,” says Devon Conway, MD, a neurologist at Cleveland Clinic’s Mellen Center for Multiple Sclerosis Treatment and Research in Ohio.

2. Get Plenty of Sleep

Practice good sleep hygiene, which includes going to bed and getting up at around the same time every day, suggests Conway. “If you sleep a lot but you still feel fatigued, you should be screened for a potential sleeping disorder,” he says.

Sleep disorders are common among people with MS but are often overlooked.

Research has found that people with MS are at an increased risk for sleep disorders like insomnia and restless legs syndrome, which are related to daytime fatigue.

3. Avoid Heat Exposure

Getting overheated is a surefire way to increase fatigue, so staying cool is a must. To survive summers in Texas, Wentink does plenty of advance planning.

“When it gets really hot, I know that if I’m going to do an activity, it has to be before the sun rises or after the sun sets,” he says. “If I’m going to one of my kids’ sporting events, I make sure I bring plenty of water.”

Seeking out shade and wearing an ice pack around his neck also help Wentink from getting overheated.

4. Take Good Care of Your Overall Health

Maintaining a healthy weight and optimal blood pressure and cholesterol levels, and avoiding type 2 diabetes can all help with MS fatigue, says Dr. Conway.

“A healthy diet and a regular exercise program can really help,” says Cohen. “If you are physically out of shape and overweight, everything you do requires more energy.”

5. Fuel Your Body With High-Quality Foods

There’s no specific diet for MS, but the National Multiple Sclerosis Society recommends following a healthy diet that prioritizes colorful fruits and vegetables, lean protein, whole grains, and healthy fats while minimizing processed foods, refined grains, and added sugars.

“Consuming simple carbohydrates such as sugary foods and highly refined foods such as white bread, white rice, or pasta can cause blood sugar levels to spike and crash. The ‘crash’ can exacerbate preexisting fatigue in persons with MS,” explains Barbara Giesser, MD, neurologist and MS specialist at Pacific Brain Health Center in Santa Monica, California, and medical reviewer for Everyday Health.

How can you avoid this? Regularly choosing high-quality foods can help, says Dr. Giesser. Good options include:

  • Protein-packed options, like beans, nuts, and lean animal proteins
  • Fiber-rich foods, like oatmeal, brown rice, and high-fiber breakfast cereals
  • Fresh fruit and leafy green vegetables
  • Fat-free or low-fat yogurt
  • Omega-3-containing foods, like salmon and walnuts

6. Practice Mindful Movement, Such as Yoga or Tai Chi

Forms of exercise that include meditation and a mind-body connection, such as tai chi and yoga, may be helpful for MS fatigue. A review of research found that mind–body exercise had the most significant effect on reducing fatigue versus other exercise in people with MS.

“Yoga can be beneficial, as it incorporates mindfulness, stretching, and low-impact exercise,” says Conway.

7. Take Breaks and Pace Yourself

Pacing yourself and taking breaks during the day can help you stay healthy, says Wentink.

“When I’m drained and continue to push, I think I’m putting myself at risk for getting sick,” he says. “When I feel fatigued, I take it as a sign that I need to step back and take a break.”

Symptoms tend to get worse when severe fatigue sets in, says Wentink. “I try to slow down before that happens because I don’t want to bring on a relapse,” he adds.

8. Discuss Energy-Boosting Medication With Your Doctor

Modafinil (Provigil) is a wakefulness-promoting medication that works for some people with MS. The antiviral medication amantadine (Symmetrel) and dalfampridine (Ampyra), a drug approved to help with walking in people with MS, are also used to counter fatigue in people with MS. Using these medications for fatigue is an off-label use. The research on how much these drugs help with MS fatigue is conflicting, with some studies concluding that they offer therapeutic benefits while other studies suggest that they’re not more effective at reducing fatigue than a placebo and more research is needed.

9. Get Help for Depression

If you are feeling down and hopeless, or if things that used to be enjoyable don’t interest you anymore, you may be depressed. Depression is one of the most common symptoms of MS, and left untreated, it can make your fatigue worse.

Depression is treatable, so if you think you might be depressed, tell your healthcare provider right away.

10. Engage in Regular Physical Activity

“I encourage exercise for my patients,” says Conway. “In my experience, it can make fatigue worse at first, but if a person can get over the initial hump, it can actually improve fatigue,” he says.

If you’re not sure how to get started with exercise or need some help identifying exercises that will improve your fitness without wearing you out, try working with a physical therapist or a personal trainer who is knowledgeable about MS.

Consulting with a physical therapist or occupational therapist about specific energy conservation strategies may also be helpful.

11. Simplify Your Life

“I have to resist being overcommitted, especially during the holidays,” says Wentink. Even though the chaos can be “beautiful chaos” with friends and loved ones, it can still cause health issues, he says. “I’ve experienced relapses in January or February, and I believe it’s because I pushed myself too hard during the holidays,” says Wentink.

Simplifying and choosing commitments carefully helps preserve energy, he says. “I feel at peace letting some things go to improve my quality of life in the long term,” he says. “I’m hoping that my overall state of health 20 or 30 years down the road will be better because of how I’m managing my life now.”

12. Manage Your Stress

Stress can make MS symptoms feel worse, and long-term stress that goes unresolved can lead to depression, anxiety, and sleep problems.

That makes it crucial to identify the sources of stress in your life and find ways to manage it.

What’s your best bet for stress reduction? “Some useful stress management techniques include getting enough restorative sleep, physical exercise, meditation, and yoga,” says Giesser.

Learning to be mindful has also been associated with stress reduction — and possibly fatigue — in people with MS.

 If you’d like to learn how to be more mindful, a variety of resources, including books, free online guided meditations, and a handful of apps, can help you get started.

Additional reporting by Becky Upham and Christina Vogt.

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Fatigue and Multiple Sclerosis. National Multiple Sclerosis Society.
  2. Broch L et al. High Prevalence of Fatigue in Contemporary Patients with Multiple Sclerosis. Sage Journals. March 18, 2021.
  3. Zhang S et al. Research Progress in Sleep Disorders Associated with Multiple Sclerosis. Multiple Sclerosis and Related Disorders. November 2025.
  4. Ghalamkari A et al. Sleep Disorders and Associated Factors in Multiple Sclerosis Patients: A Cross-Sectional Study in Iran. BMC Neurology. October 14, 2025.
  5. Kołtuniuk A et al. Sleep Disturbances, Degree of Disability and the Quality of Life in Multiple Sclerosis Patients. International Journal of Environmental Research and Public Health. March 10, 2022.
  6. Diet and Nutrition. National Multiple Sclerosis Society.
  7. Zhang XN et al. Comparison of Different Exercise Modalities on Fatigue and Muscular Fitness in Patients with Multiple Sclerosis: A Systematic Review with Network, and Dose-response Meta-analyses. Frontiers in Neurology. November 26, 2024.
  8. Rastkar M et al. The Effects of Fampridine on MS-related Fatigue: A Systematic Review. Frontiers in Neurology. January 19, 2026.
  9. Sadeqi Y et al. The Effectiveness of Amantadine and Dalfampridine in Improving Fatigue in Patients with Multiple Sclerosis: A Randomized, Double-blind, Clinical Trial. Current Journal of Neurology. October 7, 2022.
  10. Ghazanfar S et al. The Use of Modafinil for the Treatment of Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis of Controlled Clinical Trials. Brain and Behavior. July 2024.
  11. Nourbakhsh B et al. Safety and Efficacy of Amantadine, Modafinil, and Methylphenidate for Fatigue in Multiple Sclerosis: A Randomized, Crossover, Double-Blind Trial. Lancet Neurology. January 2021.
  12. Depression and Multiple Sclerosis. National Multiple Sclerosis Society.
  13. Emotional Well-being and Multiple Sclerosis. National Multiple Sclerosis Society.
  14. Hemond CC et al. A Single-Arm, Open-Label Pilot Study of Neuroimaging, Behavioral, and Peripheral Inflammatory Correlates of Mindfulness-Based Stress Reduction in Multiple Sclerosis. Scientific Reports. June 18, 2024.
Barbara S. Giesser

Barbara S. Giesser, MD, FAAN, FANA, Dipl. ABLM

Medical Reviewer

Barbara S. Giesser, MD, FAAN, FANA, Dipl. ABLM, is a neurologist who has specialized in the care of persons with multiple sclerosis since 1982. She has been faculty in the departme...

Chris Iliades

Chris Iliades, MD

Author

Chris Iliades, MD, is a full-time medical writer and journalist based in Boothbay Harbor, Maine. He practiced clinical medicine for 15 years before transitioning to medical writing...