How Pumpkin Is a Cancer-Fighting Superfood — and 3 Recipes to Get You Started

Pumpkin is a staple of autumn treats, found in everything from pies to muffins to breads. But on its own, this squash is packed with healthy nutrients that may protect against cancer.
No one food can ward off cancer, says Shaye Arluk, RDN, the nutrition and wellness coordinator at Sentara Brock Cancer Center in Norfolk, Virginia, but an overall healthy diet is certainly a good start. This fall, consider swapping pumpkin muffins for pumpkin chili — you just might find that the squash is more versatile (and healthier) than you thought.
How Pumpkin May Reduce Cancer Risk
Cell-Protecting Nutrients
Fiber for a Healthy Gut
- Bulks up stools: Fiber adds bulk to stools, speeding up their passage through the intestines. This can improve our metabolic health, protecting against certain cancers.
- Balances hormones: Fiber helps your body use insulin more effectively, which prevents cancer-promoting inflammation. It also decreases estrogen, a hormone that can increase your risk for breast cancer.
- Helps with weight management: Eating more fiber can help keep you at a healthy weight, which is one way to prevent cancer, says Arluk.
- Balances gut bacteria: Fiber helps your body maintain a healthy microbiome — the community of bacteria and other microorganisms in your digestive system. A healthy gut microbiome may, in turn, help protect against colorectal cancer.
How Much Pumpkin Should You Eat?
“A serving of pumpkin is ½ cup canned or mashed or about one cup of pumpkin cooked and cubed,” says Anna Maria Merz, RD, an outpatient oncology dietitian at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute in Columbus.
Pumpkin Seeds vs. Pumpkin Flesh
- Strengthen your immune system
- Reduce inflammation
- Protect against free radicals
Pumpkin peels and leaves — two parts of the plant that are often overlooked — are also packed with nutrients. “The pumpkin peel contains a rich source of beta-carotene, polyphenols, potassium, and fiber,” says Arluk. “Pumpkin leaves are also used globally because they contain higher levels of antioxidants, minerals, and iron than our standard greens like spinach, kale, and broccoli.”
Fresh vs. Canned Pumpkin
Canned pumpkin can be as healthy as fresh pumpkin, says Merz. Canning pulls out the water content and creates a denser product per serving, so you usually get double the fiber and more iron from canned pumpkin than from the same amount fresh, says Arluk.
“When buying canned pumpkin puree, look for '100 percent pure pumpkin' on the label or check that 'pumpkin' is the only ingredient on the ingredient list,” says Merz.
Just make sure you choose unsweetened canned pumpkin. “Avoid pumpkin pie filling or pumpkin pie mix, which often contain added sugars and syrups that increase calories without adding nutritional value,” says Tallman.
“If you opt to use fresh — rather than canned — pumpkin in your food preparation, choose baking pumpkins, also called sugar pumpkins or pie pumpkins, instead of large carving pumpkins,” says Tallman. Baking pumpkins have more sugar and less moisture, which makes them a better option for purees, pies, soups, and breads than carving pumpkins.

Roasted Pumpkin Halves
This is perhaps the easiest way to cook and enjoy fresh pumpkin at home. In fact, one might say that it’s as easy as pie. If you’re going to blend or puree the cooked pumpkin for a soup or pie, this is the way to do it.
PREP TIME
5 minCOOK TIME
35 minTOTAL TIME
40 minIngredients
Directions
Preheat oven to 400 degrees F. Line a baking sheet with parchment paper and set aside.
Slice pumpkin in half and remove all seeds and strings. Reserve seeds for roasting.
Lightly brush flesh of pumpkin with olive oil and place it cut-side down on lined baking sheet.
Carefully pierce skin of each pumpkin half with a knife in a few places.
Place baking sheet in preheated oven and bake until pumpkin can be easily pierced with a fork, about 35–45 minutes.
Allow pumpkin to cool thoroughly before handling.
Nutrition Facts
Amount per serving
Serving sizeAbout 1 cup puree
calories
57total fat
1gsaturated fat
0.2gprotein
2gcarbohydrates
13gfiber
1gsugar
5gadded sugar
0gsodium
2mgTAGS:
Anti-Inflammatory, Low-Fat, Heart-Healthy, Gluten-free, Low-Sodium, Vegetarian, VeganRate recipe
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Veggie-Packed Pumpkin Chili
With 10 grams (g) of fiber per serving, this veggie-stuffed chili really packs a nutritional punch. Plus, the smooth, pumpkin-enhanced broth is more than just nutritious, it adds a number of important nutrients to this dish as well. For example, ½ cup of pumpkin puree contains more than the recommended daily amount of vitamin A, according to the USDA and NIH.
PREP TIME
10 minCOOK TIME
27 minTOTAL TIME
37 minIngredients
Directions
Place a large pot over medium heat. Add olive oil, onion, mushrooms, and sweet potato. Cook, stirring frequently, until the onion softens, about 5 minutes. Add garlic and cook until it becomes fragrant, about 1 minute more.
Add cinnamon, cumin, chili powder, onion powder, salt, and pepper and cook for 1 minute.
Add remaining ingredients, reduce heat, cover, and simmer for 20 minutes, stirring occasionally. Serve and enjoy.
Nutrition Facts
Amount per serving
Serving size2 cups
calories
217total fat
5.8gsaturated fat
1gprotein
9gcarbohydrates
35gfiber
10gsugar
7.3gadded sugar
0.3gsodium
326mgTAGS:
Cholesterol-Conscious, Dinner, Gluten-free, Mediterranean, High-Fiber, Vegan, VegetarianRate recipe
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Curried Pumpkin Soup
Nothing combines the flavors and feelings of autumn quite like pumpkin soup. Here, the rich flavor of curry brings this soup to life while lending the anti-inflammatory benefits of the spices it contains (namely turmeric, as Johns Hopkins Medicine notes). A touch of black pepper is added to increase your body’s ability to absorb the curcumin from the turmeric, as described in the results of a past study. Low-sodium broth makes this recipe healthier for your ticker.
PREP TIME
15 minCOOK TIME
25 minTOTAL TIME
40 minIngredients
Directions
Place a large stockpot over medium heat. Add olive oil and onion and sauté until onions begin to soften, about 5 minutes.
Add garlic and apple to stockpot. Sauté, stirring occasionally, until ingredients are soft, about 5 to 10 more minutes.
Add pumpkin and broth and bring mixture to a boil, then reduce to a simmer. Cover and continue to simmer for 15 minutes.
Remove pot from heat. Blend using an immersion blender or cool slightly and use a countertop blender.
Return to stove and season with curry powder, nutmeg, cumin, salt, and pepper. Stir in milk, if using, and serve.
Nutrition Facts
Amount per serving
Serving size1⅔ cup
calories
165total fat
5gsaturated fat
0.8gprotein
3gcarbohydrates
31gfiber
4gsugar
17gadded sugar
1gsodium
369mgTAGS:
Gluten-free, Vegetarian, Vegan, Side DishRate recipe
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Resources We Trust
- Mayo Clinic: From Inflammation to Heart Health: The Perks of Pumpkin in Your Diet
- Cleveland Clinic: The Health Benefits of Pumpkin Seeds
- American Institute for Cancer Research: Pumpkin and Cancer Protection
- National Foundation for Cancer Research: Cancer-Fighting Food: Pumpkin
- Prevent Cancer Foundation: Pumpkin Spice Protein Bites
- Gavril Rațu RN et al. Pumpkin and Pumpkin By-Products: A Comprehensive Overview of Phytochemicals, Extraction, Health Benefits, and Food Applications. Foods. August 26, 2024.
- Pinna N et al. Carotenoids from Different Pumpkin Varieties Exert a Cytotoxic Effect on Human Neuroblastoma SH-SY5Y Cells. Nutrients. September 9, 2024.
- Squash, Pie Pumpkin, Peeled, Seeded, Raw. U.S. Department of Agriculture. April 24, 2025.
- Chart of High-Fiber Foods. Mayo Clinic. December 24, 2025.
- Hu J et al. Use of Dietary Fibers in Reducing the Risk of Several Cancer Types: An Umbrella Review. Nutrients. May 30, 2023.
- Celiberto F et al. Fibres and Colorectal Cancer: Clinical and Molecular Evidence. International Journal of Molecular Sciences. August 31, 2023.
- Cancer Prevention Overview (PDQ®)–Health Professional Version. National Cancer Institute. February 12, 2025.
- Farvid MS. Fiber Consumption and Breast Cancer Incidence: A Systematic Review and Meta-Analysis of Prospective Studies. Cancer. April 6, 2020.
- Fu J et al. Dietary Fiber Intake and Gut Microbiota in Human Health. Microorganisms. December 18, 2022.
- Kandalai S et al. The Human Microbiome and Cancer: A Diagnostic and Therapeutic Perspective. Cancer Biology & Therapy. July 27, 2023.
- Dietary Guidelines For Americans, 2025–2030. U.S. Department of Agriculture. 2025.
- Kassa MG et al. Phytochemical Composition, Health Benefits, Functional Properties, and Food Applications of Pumpkin Seeds. Food Science & Nutrition. May 8, 2026.
- Seeds, Pumpkin Seeds (Pepitas), Raw. U.S. Department of Agriculture. April 20, 2023.
- Peng M et al. Effect of Roasting on the Antioxidant Activity, Phenolic Composition, and Nutritional Quality of Pumpkin (Cucurbita pepo L.) Seeds. Frontiers in Nutrition. March 10, 2021.
- Raza N et al. Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights. Food Science & Nutrition. January 28, 2026.
- Batool M et al. Nutritional Value, Phytochemical Potential, and Therapeutic Benefits of Pumpkin (Cucurbita sp.). Plants. May 24, 2022.

Jennifer Frediani, PhD, RD
Medical Reviewer
Jennifer K. Frediani, PhD, RD, ACSM-CES, is a nutrition scientist, exercise physiologist, and registered dietitian with over two decades of experience in clinical research, educati...

Abby McCoy, RN
Author
Abby McCoy is an experienced registered nurse who has worked with adults and pediatric patients encompassing trauma, orthopedics, home care, transplant, and case management. She is...