11 Common Symptoms Women Should Never Ignore

11 Common Symptoms Women Should Never Ignore

11 Common Symptoms Women Should Never Ignore
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Once most people hit their forties, an array of symptoms begin to pop up. Many of them are simply changes that come with natural aging. However, some symptoms can signal serious health problems.

Paying attention to when new symptoms occur and looping in your physician can help you stay on top of your health and longevity. Here are 11 symptoms you shouldn’t ignore.

1. Out-of-the-Ordinary Breast Changes

The size, feel, and look of your breasts is as individual as you are, and breasts often change throughout the menstrual cycle. Some women normally have lumps; others get a lump every month before their period.

Not all breast changes point to cancer, says Rosmy Barrios, MD, director of the Regenerative Medicine Department at the Specialized Clinic for Regenerative Medicine P.A.R.K.S in Novi Sad, Serbia. But it’s always better to err on the side of caution and get it checked out.

Breast cancer can appear as an unusual redness of the skin that looks like an infection, swelling, lumps, bumps, or nodules.

 Other potential symptoms include nipple discharge that’s bloody, nipple changes, and breasts that become unusually asymmetrical. Breast cancer can also appear without any signs or symptoms.

Susan Oakley, MD, a urogynecologist at St. Elizabeth Healthcare in Newport, Kentucky, recommends yearly mammograms after you turn 40. She suggests people schedule it during their birth month to help them remember.

2. Irregular Vaginal Bleeding

Irregular vaginal bleeding can have a number of explanations, including:

  • Birth control changes
  • Cervical or vaginal infections
  • Intercourse
  • Perimenopause
  • Sexually transmitted infections

In addition to these factors, irregular vaginal bleeding can also be the first sign of cervical or uterine cancer, says Dr. Oakley, “so it is critical to stay up-to-date with your Pap smear and reach out to your gynecologist if this bleeding occurs.”

While unexpected bleeding can be normal before menopause, if you experience any bleeding postmenopause, reach out to your doctor right away.

 “Do not wait for it to happen twice,” Oakley says.

3. Sudden Weight Changes

Unexplained changes in weight can be a sign of a health problem. For example, weight loss can be a symptom of gastrointestinal problems, while weight gain may be a warning sign of thyroid issues.

If you gain or lose 10 or more pounds over 6 to 12 months, it could be a sign of a medical issue. “Without changing your diet or activity levels,” says Oakley, “sudden weight gain could indicate a benign tumor in your body producing abnormal amounts of certain steroids or hormones [or another cause].”

“One of the most common causes of sudden weight gain is hypothyroidism,” explains Dr. Barrios. Hypothyroidism is a condition where the thyroid gland doesn’t make enough hormones, which can lead to weight gain and fatigue, among other symptoms.

Barrios says weight gain can also result from:

Some symptoms that may seem harmless, like bloating, can actually be an early indicator of issues like bowel obstruction or even certain cancers, like ovarian cancer.

 While you may not want to run to the doctor every time you feel gassy, be sure to mention the symptom during your annual checkup.
Illustrative graphic titled Symptoms Women Should Never Ignore shows Out-of-the-ordinary breast changes Irregular vaginal bleeding Sudden weight changes  Moles that bleed or change Persistent leg pain Persistent heart palpitations  Chest pain
Everyday Health

4. Moles That Bleed or Change

Moles can be troublemakers for the skin, and people can fail to catch problems early. A good rule of thumb, says Oakley, is to follow the “ABCDEs” when checking any mole for signs of possible melanoma:

  • Asymmetric appearance
  • Border that’s irregular
  • Color variation
  • Diameter larger than a pencil eraser
  • Evolving size, color, and shape

“If you have a mole that changes or bleeds,” says Laura Purdy, MD, a family medicine physician in private practice in Calabasas, California, “then you definitely want to check in with your doctor to see if you need to have a biopsy.”

If there's a history of skin cancer in your family, watch your moles even more closely, and get them routinely checked. If you have a concern about a mole, it may be wise to take a photo of it every six months to make it easier to notice changes over time.

5. Persistent Leg Pain

Random leg pains can flare up from time to time, but if your leg pain hangs around, you may want to get it checked out. Leg pain can come from something as simple as a strained muscle, or a more notable issue like a tendon injury in your knee.

For simple muscle aches and pains, you can treat your symptoms at home with rest, ice, and elevating your leg. If the pain persists, however, work with your physician to decide if more intervention or treatment is needed.

Swelling and pain in one leg that doesn't go away may signal a blood clot, known as deep vein thrombosis (DVT). The swollen leg can also be darker in color or painful.

These signs should be tended to at once, particularly if you’re at higher risk for DVT. “Sometimes,” says Dr. Purdy, “blood clots can break off and become clots in the lungs, which can be life-threatening.”

If you’re at risk for DVT and develop a red, swollen calf that is warm to the touch, seek medical attention immediately.

6. Heart Palpitations Lasting 15 Minutes or Longer

Whether it’s from stress or exercise, it’s not uncommon to occasionally experience your heart fluttering or pounding in your chest. A few seconds or even minutes of heart palpitations can be benign, says Oakley. But if they last longer than 15 minutes, that could mean a more serious problem, like heart arrhythmia or heart disease.

Atrial fibrillation, a type of heart rhythm disorder, can cause your heart to beat irregularly and can significantly increase your heart rate, leading to your heart’s upper and lower chambers not working together properly. When prolonged, this can result in blood clots that can move to other parts of the body and may lead to stroke or heart failure over time.

If you experience palpitations along with other symptoms, such as trouble breathing, chest pain, or chest pressure, Oakley says to seek medical help.

7. Chest Pain

Your chest can hurt for all sorts of reasons. Heartburn, anxiety, and muscle aches can all spark this symptom.

“Chest pain is absolutely a symptom that you don’t want to ignore,” Purdy says. If you experience chest pain at rest or with activity, let your healthcare provider know. This is particularly important if the pain goes away after a short period of rest, which can indicate a blocked artery around the heart.

Heart disease is the number one killer of women in America today.

The most common heart attack symptom in men and women is chest pain or discomfort. But women may experience other symptoms such as shortness of breath, dizziness, nausea and vomiting, extreme fatigue, a cold sweat, or pain in the arms, back, neck, or stomach.

 Because symptoms may vary, there’s a chance that they can be missed. So it’s best to get these and any other symptoms checked out.

8. Worsening Shortness of Breath

Don’t ignore shortness of breath, assuming it’s from a lack of exercise or recent weight gain. If you experience shortness of breath after exertion that progressively gets worse, it could be a sign of a heart disease like aortic stenosis (the narrowing of a main artery leaving the heart) or coronary artery disease (a partial blockage in an artery leading to the heart).

Another common cause of shortness of breath is congestive heart failure (CHF). If you have CHF, your body doesn’t handle changes in fluid levels well. That’s because your heart can’t pump effectively, causing a traffic jam of sorts, making it hard to get rid of extra fluid in your body.

The fluid then leaks into spaces it’s not supposed to be, including your lungs, causing shortness of breath. Check with your doctor if you have shortness of breath that suddenly or progressively gets worse.

9. Sudden Changes in Your Vision

As you age, it’s normal for your vision to change over time. But don’t ignore visual changes that affect only one eye, the sudden onset of double vision, sudden pain, or the inability to see the center of what you’re looking at.

Vision changes, explains Oakley, can come from something as simple as eyestrain from looking at your computer too long. But it can also point to macular degeneration, glaucoma, or more serious problems like concussion or stroke, especially if the symptoms come on suddenly.

Sudden vision changes can also be caused by other medical conditions, says Barrios, including:

“Some types of sudden vision change can actually be vision threatening,” says Purdy, “and so every moment counts.” If you experience symptoms like pain, headache, or bleeding anywhere on the eyeball, you should see a physician immediately.

10. Unexpected Bowel Habit Changes

Changes in bowel movements may indicate whether something’s gone wrong in the body. Symptoms like bleeding or blood in the stool, changes in the amount, frequency (either constipation or diarrhea), consistency, or appearance of stools, can signal a health problem.

Conditions like irritable bowel syndrome, inflammatory bowel disease, colon cancer and anal cancer can be the reason behind the change in bowel habits.

“While most changes in bowel habits or stool consistency are related to our diet and activity level,” says Oakley, “you should see your physician immediately if you notice unprovoked rectal bleeding, very black ‘tarry’ stools, or a large amount of mucus consistently with each bowel movement.”

11. Extreme Fatigue

Feeling tired after a night of interrupted sleep usually isn't cause for concern, but unexplained or extreme fatigue can be a sign of something more serious.

For example, fibromyalgia, a disorder that causes chronic deep muscle pain, may also cause debilitating fatigue and headaches. Severe fatigue may also be caused by serious conditions that need medical attention, including anemia, respiratory conditions like COPD, chronic kidney disease, diabetes, and cancer.

Antihistamines, antidepressants, and pain medicines at higher doses can cause significant fatigue.

If you experience severe fatigue symptoms for several weeks, set up an appointment with your healthcare provider. Your physician will likely perform an exam, ask about your health history, and order laboratory tests to make sure nothing urgent is going on.

Headache, nausea, fatigue, and achiness may be signs of a common cold or flu virus or a sign of heatstroke, especially in older adults. If you suspect heatstroke — call 911 or medical personnel immediately.

The Takeaway

  • As you age, you’ll likely start to experience new aches and pains, many of which are a normal part of getting older.
  • Some symptoms, however, may signal a serious health issue. Unexpected or severe pain, bleeding, or fatigue are all signs you should reach out to your doctor right away.
  • Conditions like diabetes, heart failure, and even cancer can show early signs that may be overlooked.
  • Keeping track of your symptoms and communicating them to your doctor can help catch issues early.

Additional reporting by Abby McCoy.

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
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  2. Breast Cancer Early Detection and Diagnosis. American Cancer Society.
  3. Vaginal Bleeding. Mayo Clinic. May 02, 2023.
  4. Auguste TC. Bleeding After Menopause Could Be a Problem. Here's What to Know. American College of Obstetricians and Gynecologists. February 2024.
  5. Unexplained Weight Loss. Cleveland Clinic. August 5, 2024.
  6. Unexplained Weight Gain. Cleveland Clinic. April 24, 2025.
  7. Bloated Stomach. Cleveland Clinic. September 10, 2021.
  8. Find skin cancer: How to perform a skin self-exam. American Academy of Dermatology Association. May 15, 2023.
  9. Leg Pain. Mayo Clinic. April 25, 2023.
  10. Know the Risks, Signs & Symptoms of Blood Clots Infographic. Centers for Disease Control and Prevention. May 15, 2024.
  11. Atrial Fibrillation. Mayo Clinic. January 14, 2026.
  12. About Women and Heart Disease. Centers for Disease Control and Prevention. May 15, 2024.
  13. Heart Attack Symptoms in Women. American Heart Association. December 13, 2024.
  14. Aortic Stenosis Overview. American Heart Association. May 23, 2024.
  15. Heart Failure and Congenital Heart Disease. American Heart Association. December 18, 2025.
  16. Sudden Vision Loss. Cleveland Clinic. February 19, 2023.
  17. Changes in Bowel Habits. Cleveland Clinic. September 21, 2023.
  18. Fatigue. Mayo Clinic. February 20, 2026.
  19. Common Cold. Johns Hopkins Medicine.
  20. Heat-related Illnesses. Centers for Disease Control and Prevention. March 3, 2026.
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Michelle Seguin, MD

Medical Reviewer

Michelle Seguin, MD, is a board-certified family medicine, lifestyle medicine, and certified functional medicine physician (IFMCP). She is a practicing physician at Root Functional...

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Tammy Worth

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Tammy Worth is a freelance healthcare reporter based in Kansas City, Missouri. She has been in the industry for 20 years, during which time she was a reporter and then editor at a ...