GLP-1s, Obesity, Emotional Eating, and Binge Eating

Can GLP-1s Treat Emotional Eating and Binge Eating in People With Obesity?

Can GLP-1s Treat Emotional Eating and Binge Eating in People With Obesity?
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Blockbuster GLP-1 weight loss drugs like semaglutide (Ozempic, Wegovy) help people eat less by dampening hunger and the persistent thoughts known as food noise. But so far, there’s less scientific evidence showing that these medications can prevent emotional eating, particularly for people with binge eating disorder, a diagnosable mental health condition.

While GLP-1 drugs can alter the chemistry of hunger in powerful ways, they don’t necessarily help with the emotional and psychological factors often found at the root of eating disorders. Some evidence suggests that these medications may be able to help some people binge less, but experts do not yet recommend them as a replacement for traditional mental health therapy, and more research is necessary before healthcare professionals would consider them a standard part of treatment.

Some healthcare professionals prescribe GLP-1s off-label for binge eating disorder. As you consider your options, touch base with your healthcare provider to understand how GLP-1s work, consider the risks and benefits, and understand what may happen if you stop taking the medication.

GLP-1s, the Brain, and Food Noise

Food noise refers to constantly thinking about food to a point where it may become excessive or harmful, and it may be associated with binge eating.

For example, you may start thinking about your next meal during or immediately after eating, or struggle to focus due to food-related mental chatter.

GLP-1 receptor agonists seem to help reduce food noise by reducing hunger signaling and increasing satiety, says Chris Esposito, DO, a bariatric surgeon at Northwell’s Staten Island University Hospital in New York.

However, while GLP-1s can decrease the reward sensation from food by making you less hungry, they don’t necessarily treat the underlying causes of eating disorders, Dr. Esposito adds. And because there’s so little protocol in place to screen for eating disorders prior to prescribing these weight loss drugs, scientific research on the effectiveness of treating these conditions with GLP-1s is a developing field.

GLP-1s and Emotional Eating

Emotional eating refers to consuming food to cope with negative emotions, and common triggers include relationship conflicts, work issues, or financial pressures.

One review of dozens of studies shows that factors like psychological distress, prolonged stress, depression, and anxiety play a role in emotional eating.

“Emotional eating can be multifactorial, but food provides a form of psychological comfort or outlet in times of stress,” Esposito says. “GLP-1s do not relieve stress or treat the underlying stressors.”

It is possible that GLP-1s can help suppress emotional eating: Esposito says that the feeling of fullness they provide could make overeating in response to emotional stress less desirable. However, these medications will not address other psychological factors involved in emotional eating, including anger, fear, or boredom, he says.

“I am not sure GLP-1s can help emotional eaters, and if they do, I fear that it’s only by helping people to restrict more, which is the opposite of what we do in psychotherapy for binge eating and emotional eating,” adds Lauren Muhlheim, PsyD, owner of Eating Disorder Therapy LA in Los Angeles.

GLP-1s and Binge Eating Disorder

GLP-1s do not currently have approval from the U.S. Food and Drug Administration (FDA) as a treatment for binge eating disorder. Healthcare professionals do, however, prescribe them off-label as an anti-binge drug. “Off-label” means that a healthcare professional might prescribe an approved medication for purposes other than its approved use if they judge that it can be safe and effective for a different problem.


Eating disorders in general are complex, and a variety of factors may influence them. These can include genetics, brain biology, cultural and social ideals, and underlying mental health conditions.

Binge eating disorder is a more serious condition than emotional eating. While emotional eating often ebbs and flows as a source of stress relief, binge eating involves rapid, large meals with a loss of control, often followed by episodes of intense shame.

GLP-1 medications can’t alleviate symptoms caused by all of these factors, but they may help certain patients by addressing some of the biological causes of hunger.

“For some people with binge-type eating disorders, these medications appear to mitigate some of the biological roots of disordered eating,” says Kim Dennis, MD, founder of the therapy practice SunCloud Health in Chicago and member of the National Association of Anorexia Nervosa and Associated Disorders’ Scientific Advisory Board.

A systematic review that pulled data from 8,069 participants across 25 randomized controlled trials found that taking GLP-1 agonists led to results beyond weight loss. They also helped to reduce episodes of binge eating, emotional eating, and loss-of-control eating.

The study highlights that GLP-1s could be a vital part of a binge eating treatment plan in the future, alongside psychological therapy and social support. However, the study authors highlight that further research is necessary, as it’s unclear whether the increased dietary restraint that GLP-1s may contribute to is helpful for self-control or may instead lead to imbalanced forms of restricted eating, such as skipping meals.

Because of this medication’s limitations in terms of treating the emotional aspects of eating, it also won’t address trauma or body image distortions, for example, if those issues are at the root of a person’s eating disorder, Dr. Dennis adds.

“Further evidence will be necessary before we can see the complete picture, but they show promise as, at the minimum, an adjunct to current therapy,” says Esposito.

When to See a Doctor About Binge Eating or Emotional Eating

If you have a binge eating disorder or display symptoms of emotional eating, it’s important to discuss your symptoms with your provider to determine treatment options beyond any improvements you may see from GLP-1 medications.

Treatment

Treatment for emotional eating and binge eating currently involves addressing the mental health conditions behind them, such as shame, poor body image, negative emotions, and depression. This may include talk therapy like cognitive behavioral therapy (CBT), which helps you manage triggers, including enhanced CBT (CBT-E), which is specifically shaped for eating disorders.

For those with binge eating disorders, doctors may also prescribe lisdexamfetamine dimesylate (Vyvanse). Although it’s a medication for attention-deficit/hyperactivity disorder (ADHD), the FDA has approved it to treat moderate to severe binge eating disorder in adults. However, it’s a stimulant that can be habit-forming.

In time, GLP-1s may join the roster of approved treatments for binge disorder, but longer-term randomized controlled trials are necessary to test their long-term impact on health and assess whether short-term improvements may lead to sustainable positive changes.

Recognizing Binge Eating Disorder

If you have not yet received a binge eating disorder diagnosis, your doctor may ask questions and analyze your answers according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Criteria include:

  • Eating an abnormally large amount of food
  • Experiencing loss of control
  • Eating far more rapidly than normal
  • Eating until uncomfortably full
  • Consuming large amounts of food when not physically hungry
  • Eating alone out of embarrassment for the quantity
  • Self-loathing, depression, or guilt after overeating

Doctors don’t consider purging food, vomiting, taking laxatives, or overexercising to be diagnostic criteria for binge-eating disorder, and the behaviors above must occur at least once a week.

Resources We Trust

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Sean Hashmi, MD

Medical Reviewer

Sean Hashmi, MD, is an experienced nephrologist and obesity medicine specialist based in Southern California. As the regional director for clinical nutrition and weight management ...

Kelsey Kloss

Author

Kelsey Kloss is a health and wellness journalist with over a decade of experience. She started her career as an in-house editor for brands including Reader’s Digest, Elle Decor, Go...