How to Take Care of Your Mental Health on a GLP-1

How to Take Care of Your Mental Health on a GLP-1

Everyday Health independently vets all recommended products. All prices are accurate at time of publish. If you purchase a featured product, we may be compensated. Learn why you can trust us.
The recent popularization of GLP-1s has been a game-changer for people managing obesity, type 2 diabetes, and other ongoing (chronic) health conditions. GLP-1s affect appetite and reward pathways in your brain. That helps reduce hunger and food cravings for many people, which can trigger significant weight loss.

 You may find yourself losing weight and noticing some of the health improvements that led you to start a GLP-1 in the first place. Yet, your feelings may be complicated.

“Body changes may result in sudden feelings of emotional distress that include anxiety, grief, and uncertainty,” says Kat Grassetti, LCSW, a San Diego-based women’s health specialist and the clinical director at Monima Wellness Center. In response to these difficult feelings, Grassetti recommends practicing body neutrality. That means you focus on what your body is physically able to do rather than how it looks. “[Observing] the gradual shift in your physical body without pressure will help you adjust,” she says.

Then, there's the physical attention that accompanies weight loss. Folks may make comments on your changing body, which can feel triggering. It’s important to prepare for these situations and figure out what works best for you. A friend’s “You look great!” can be a double-edged sword, especially if you’re feeling uncertain about your weight loss journey. Set your own goals and try not to validate yourself and your body based on others’ opinions. Feeling better about yourself is the most important feedback.

We’re here to help with some great ways you can take care of your mental health while on a GLP-1, including practical strategies and professional support you can seek along the way.

What Is a GLP-1 and How Can It Help Me?

First, let’s get down to the basics: GLP-1 stands for glucagon-like peptide-1. These medications work similarly to your body’s preexisting gut hormones. More insulin is created, and levels of glucagon (a hormone that helps control blood sugar) decrease. These effects can lead to less appetite and, for many people, significant weight loss over time.

GLP-1s are used in some surprising ways, too. For example, some doctors prescribe GLP-1s for alcohol use disorder, because these meds may help reduce cravings for alcohol and lessen its rewarding effects. Early research suggests that this use is most effective when combined with cognitive behavioral therapy, a type of talk therapy that can also be helpful when taking a GLP-1 for weight loss.


What Are the Risks of Taking GLP-1s?

If you want to take GLP-1s, be aware that they can come with some risks and side effects. In the short term, you may have nausea, vomiting, diarrhea, and constipation. Not much data exists on the long-term effects due to how new these drugs are. But studies suggest that persistent use of GLP-1s can result in serious bone mass and muscle loss, along with weight regain after you stop taking the drug.

Some rare but potentially serious risks have been reported, including pancreatitis, kidney issues, depression, and suicidal thoughts.

 This is why it’s critical to stay in close contact with your healthcare professional and why we recommend getting regular psychotherapy while on a GLP-1.
GLP-1s are legitimate prescription drugs that can play an important role in treating obesity, type 2 diabetes, and other health conditions when prescribed appropriately. These medications also can be misused. It’s becoming increasingly common for folks to use these as weight loss medications while in the depths of disordered eating or body image issues. Many also pursue GLP-1s as a quick way to lose weight without making sustainable lifestyle changes, which can make it harder to stay at a healthy weight long-term.

While some people may be tempted to seek out GLP-1s mainly for cosmetic weight loss, these medications aren't appropriate for everyone to take. They should be used only under the guidance of a qualified healthcare professional. GLP-1 use can be especially risky for those who have a history of disordered eating or body image issues.

Online Therapy for Help With the Weight-Loss Emotional Roller Coaster

Weight loss isn’t just a change in your body; it’s an emotional change, too. Body image issues can spike with weight loss, because it can lead to a hyper-focus on your body as it changes, says Susan McClanahan, PhD, a licensed clinical psychologist and cofounder of SpringSource: Eating, Weight & Mood Disorders in Chicago. Connecting with professional support is one of the best ways to weather these tides. A therapist can help as you unpack the mental repercussions of losing weight, develop a changing relationship to food, or hit a plateau.

Brightside Health

For Cognitive Behavioral Therapy

Brightside Health

Cognitive behavioral therapy (CBT) helps you identify negative or harmful thoughts and change the way you react to them. This can be especially useful for someone whose body is changing fast and who turned to a GLP-1 because of body image issues. This type of therapy can help you change how you think about your body and build more positive associations and attitudes.

Brightside Health is an online therapy platform specializing in CBT. We found Brightside Health’s therapists highly skilled, and we appreciated the coping skills program included in the monthly plan. We were also impressed with its affordability. You won’t pay more than $349 a month for weekly therapy sessions, unlimited messaging with your mental healthcare professional, and psychiatry services if you need medication in addition to therapy.

Talkspace

For Those With a Chronic Illness

Talkspace

If you’re using a GLP-1 for an ongoing illness that prevents you from losing weight naturally, getting therapy with a professional who specializes in chronic illnesses can be invaluable. Talkspace offers access to therapists with experience supporting people living with long-term conditions, making it an excellent option for this type of care.

OurRitual logo

For Couples Therapy

OurRitual

Life on a GLP-1 can feel very different. Changing eating habits can affect your social life, as you may go out to meals with loved ones less often. You could be in situations where you simply aren’t hungry, and others might make comments about your lack of appetite.

Your relationship with your partner may be most impacted. If one partner has changes in appetite and energy, it can affect the relationship dynamic. Your partner may feel left behind or may wonder how best to support you on your journey.

We thoroughly enjoyed our time using OurRitual’s couples counseling services. The company has a subscription model with live sessions and self-guided tools. OurRitual uses an approach called the Gottman method and emotionally focused therapy. The goal is to boost communication, connection, intimacy, and conflict-resolution skills.

innerwell logo

For Those With Trauma

Innerwell

If you have a history of trauma — especially trauma related to body image, weight loss, or medical ailments — seeking support from a trauma specialist is a good idea. We especially love Innerwell for this. Eye movement and desensitization and reprocessing therapy (EMDR) has been shown to be effective for treating trauma.

 Innerwell has a roster of therapists who specialize in EMDR, making it a great option for deep, lasting healing.

“For people who used food to manage stress, anxiety, or difficult emotions, the reduction in appetite can actually surface feelings they haven’t had to sit with in years,” says Dr. McClanahan. Trauma therapy can be immensely helpful in getting to the root of those painful emotions and difficult experiences, and it can teach you new ways to cope with stressors that don’t involve eating. Grassetti says it’s important to notice when you’re experiencing emotional triggers and question whether they’re linked to your eating habits.

Grow therapy logo

For Eating Disorder Support

Grow Therapy

Your self-worth isn’t based on your weight, but that knowledge alone may not be enough to stop self-judgment. “Self-judgment tends to spike when progress stalls, when weight comes back, or when someone compares their experience to what they expected or what someone else reported,” says McClanahan.

It can be difficult to maintain perspective when any of these things happen, so opting for regular therapy sessions can keep you on track. We like that Grow Therapy features a wide range of therapists throughout the country who accept insurance. And many of them specialize in body image and eating disorders.

Those with active restrictive eating disorders, like anorexia nervosa or atypical anorexia, shouldn’t take a GLP-1 unless they work closely with an eating disorder specialist, McClanahan says. Emerging research suggests some GLP-1 use can reduce binge eating, indicating some usefulness when treating binge eating disorder. But it’s still key to also get help from mental health professionals.

One-Stop Shops: Telehealth for GLP-1s and Therapy

When assessing your options for starting a GLP-1, it’s best to work with a healthcare professional and a mental health specialist. They can help you sort through the factors influencing your decision, especially issues related to body image or your relationship with food. A therapist can be a good sounding board when you’re thinking about starting a GLP-1.

“GLP-1 medications can be genuinely life-changing for the right patient, but they are not appropriate for everyone, and the psychological screening piece is often skipped,” says McClanahan. A telehealth platform that offers both GLP-1s and online therapy can seriously streamline your healthcare, and it may even help save you money on memberships.

PlushCare

With Insurance

PlushCare

If you’re looking for a telehealth option that takes your insurance, check out PlushCare. It accepts most major insurers, including UnitedHealthcare, Anthem BlueCross, Cigna, Aetna, and Humana. PlushCare is one of the few platforms that offers physician-guided weight loss medication as well as mental health therapy and medication. It can also serve as your online urgent care provider, making it a true one-stop healthcare shop.

We had a good experience testing therapy with PlushCare. We believe it would work well for someone who needs guidance on a specific situation, such as GLP-1 use. Appointments may be available as soon as the same day, depending on the service. Membership is around $20 a month, plus your copay if using insurance or $129 per visit without insurance.

Sesame logo

Without Insurance

Sesame

Care without insurance may not be synonymous with affordability, but Sesame is trying to change that. The company’s online weight loss program starts at $59 per month (payable in a lump sum of $708 for a 12-month, nonrefundable commitment). Therapy appointments may be as little as $94 with a Sesame Plus membership, which costs $10.99 per month or $99 per year, no insurance required. Mental health medication is also available, as is online urgent care and prescription refills. You may also be able to access in-person appointments with the service. It’s a great model for those seeking convenient, affordable care without insurance.

Psychiatry and Medication Management

If you’re on psychiatric medication or you’re interested in trying one, you’ll want to connect with a psychiatrist who understands your goals and current medication usage. They can help you select the best medication that will balance harmoniously with a GLP-1.

Many psychiatric medications can lead to weight gain, so you may have chosen to start a GLP-1 because of the side effects of a psychiatric drug.

Conversely, some GLP-1 users say they get psychiatric side effects, such as a flattened affect or a loss of interest, that may be improved by medication. Research into this connection is mixed, though.

Rula logo

For Psychiatry and Therapy

Rula

For those seeking psychiatric care and medication management, as well as therapy, we highly recommend trying Rula. We had a great experience with the service. Its therapists were experienced, thoughtful, attentive, and easy to connect with. We love that you can choose your own therapist from a list of recommended matches and that the portal makes it easy to communicate with your mental health professional between appointments.

The service is in-network with most insurance. Therapy and psychiatry appointments may be available as soon as the next day. For psychiatry, the service matches you with healthcare professionals covered by your insurance.

Talkiatry logo

With Insurance

Talkiatry

For a psychiatry service that’s exclusively available via insurance, we like Talkiatry. Its healthcare professionals can prescribe a variety of medications, including those for anxiety and depression. These two conditions can easily surface as your body changes and your brain struggles to keep up. Talkiatry excels at connecting you with a telehealth psychiatrist who can help you understand your symptoms and guide you as you work together to find the best medication for your situation.

Dietitians to Help Maximize Your Nutrition

Taking a GLP-1 isn’t where the support ends. While taking the medication, it’s best to embrace lifestyle changes such as eating nutritious food and working exercise into your daily routine. This is how you create habits you can keep up beyond your time spent using the drugs.

When considering new healthy habits, take a holistic approach that accounts for both the emotional and physical changes you’re going through. Try to find physical activities you love, stick to regular mealtimes, and get quality sleep, says Grassetti. A dietitian can help you develop sustainable nutrition habits alongside GLP-1 treatment. They can help support your long-term health and make future transitions off medication easier.

Also, keep in mind that taking a GLP-1 changes your physical relationship to food, but not the mental associations. “It does not rewrite the psychological patterns, histories, and coping behaviors that shaped [a person’s] relationship with food,” says McClanahan.

So even though your body physically doesn’t experience hunger in the same way, taking a GLP-1 allows you to lose weight without changing what you eat or how you eat. For example, if you’ve always downed a pint of ice cream after a particularly grueling day, taking a GLP-1 won’t change that urge. And that urge will still be there if and when you stop the medication.

Nourish logo

With Insurance

Nourish

GLP-1s call for a new relationship to how nutrition is approached. Nourish is a program that provides access to registered dietitians covered by insurance. Partnering with one can help you begin to create sustainable meal plans and healthy food habits. Plus, working with a dietitian has been shown to improve GLP-1 treatment outcomes.

Fay nutrition logo

For Specialized Diets

Fay Nutrition

Special diets, dietary needs, medications, and coexisting conditions need knowledgeable nutrition experts. Fay Nutrition’s dietitians offer specialized nutrition counseling for a wide array of situations. Have a chronic illness? Vegetarian or vegan? Have a history of disordered eating? Food sensitivities or allergies? These dietitians can help plan meals around such needs, and many more. Plus, Fay Nutrition takes most insurance.

You may also find yourself exercising more, but with a reduced appetite on a GLP-1, it can be a struggle to get enough to eat to power your workouts. Dietitians can help you optimize and balance your nutrition.

How Can I Work On Having a Better Body Image?

It can be easy to conflate health with body size. But the truth is that body size can have very little to do with health.

 A larger body size doesn’t necessarily equate to poor health, contrary to the assumptions of many. Rather, health involves a wide variety of factors. So, the idea that a smaller body is related to enhanced health can actually feed into disordered body image and eating.

McClanahan recommends staying connected to how you feel rather than to your physical appearance. Is it getting easier to climb steps? Can you walk for longer without getting winded? These are positive results that support body neutrality and shift the focus away from aesthetics.

It also helps to notice when external feedback is pulling you away from your own unique experience. Having a discussion with your friends and loved ones that sets boundaries around your weight loss can be very helpful. If you don’t want anyone commenting on your body, tell them that. Or if you do want positive feedback, tell them that, too. You decide who to listen to and who needs to keep their opinions to themselves.

Practicing self-compassion is key. You’ll need to give yourself time to adjust and grace while doing so. Your body might be changing more quickly than your attitude can. It’s hard to unlearn years of experience with your old body, so be patient with yourself as you lose weight.

Why Trust Everyday Health

We independently investigate and recommend products and services we believe will enrich the lives of our readers and meet their specific needs. You can trust our reviews because we do the legwork for you. Read more about why you can trust us.

Julia Childs Heyl, MSW

Author

Julia Childs Heyl, MSW, is a California-based clinical social worker and mental health writer. Her writing often focuses on mental health disparities and uses critical race theory ...

Angela-Harper-bio

Angela D. Harper, MD

Medical Reviewer

Angela D. Harper, MD, is in private practice at Columbia Psychiatric Associates in South Carolina, where she provides evaluations, medication management, and psychotherapy for adul...

Orlando de Guzman

Fact-Checker

Orlando de Guzman is a writer and editor with expertise in health and environmental news. He has a background in investigative and science journalism and has worked on documentary ...

Olivia Campbell

Editor

Olivia Campbell is the New York Times bestselling author of Women in White Coats: How the First Women Doctors Changed the World of Medicine and Sisters in Science: How Four Women P...

Hannah Owens

Hannah Owens, LMSW

Tester

Hannah Owens is a licensed social worker and mental health writer and editor with a background in community mental health. Currently, she is a freelance writer and editor at Everyd...

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Eren-Yazicioglu CY et al. Can GLP-1 Be a Target for Reward System Related Disorders? A Qualitative Synthesis and Systematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol. Frontiers in Behavioral Neuroscience. January 18, 2021.
  2. Olukorode JO et al. Recent Advances and Therapeutic Benefits of Glucagon-Like Peptide-1 (GLP-1) Agonists in the Management of Type 2 Diabetes and Associated Metabolic Disorders. Cureus. October 21, 2024.
  3. Klausen MK et al. Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial. The Lancet. May 2, 2026.
  4. UC Davis Health examines systemic impact of GLP-1–based therapies. UC Davis Health. December 5, 2025.
  5. Kim JA et al. Exploring the Side Effects of GLP-1 Receptor Agonist: To Ensure Its Optimal Positioning. Diabetes & Metabolism Journal. July 1, 2025.
  6. Gainer D et al. A FLASH OF HOPE: Eye Movement Desensitization and Reprocessing (EMDR) Therapy. Innovations in Clinical Neuroscience. July 1, 2020.
  7. Aoun L et al. GLP-1 receptor agonists: A novel pharmacotherapy for binge eating (Binge eating disorder and bulimia nervosa)? A systematic review. Journal of Clinical & Translational Endocrinology. February 29, 2024.
  8. McIntyre RS et al. Psychotropic Drug–Related Weight Gain and Its Treatment. American Journal of Psychiatry. January 1, 2024.
  9. A new era of weight loss: Mental health effects of GLP-1 drugs. American Psychological Association. July 1, 2025.
  10. Despain D et al. Optimizing nutrition, diet, and lifestyle communication in GLP-1 medication therapy for weight management: A qualitative research study with registered dietitians. Obesity Pillars. October 13, 2024.
  11. Richards JR et al. Highway to the danger zone? A cautionary account that GLP-1 receptor agonists may be too effective for unmonitored weight loss. Obesity Reviews. February 6, 2024.