What Causes Blood in Urine (Hematuria)?

Blood in your urine may indicate various medical conditions, particularly those affecting the kidneys, bladder, urinary tract, and prostate.
Causes of Hematuria
- Bladder or kidney stones
- Kidney disease
- Kidney injury
- Enlarged prostate
- Urinary tract infection
- Blood clots
- Kidney infections
- Cancer of kidneys, bladder, or urethra
- Sickle cell anemia
- Blood at the beginning of urination may mean the bleeding originates in the urethra.
- Blood in the urine stream may be due to your bladder, kidneys, or ureters.
- Blood at the end of urination may suggest that the cause involves the bladder or prostate.
- cyclophosphamide (Cytoxan)
- penicillin
- aspirin
- heparin
- anticoagulants such as warfarin (Coumadin), rivaroxaban (Xarelto), dabigatran (Pradaxa), or apixaban (Eliquis)
Blood may also come from these other sources:
- The vagina during menstruation
- Ejaculation in men (often because of a prostate problem)
- A bowel movement due to hemorrhoids or other issues
What Causes Small Blood Clots in Urine?
Can Dehydration Cause Blood in Urine?
While dehydration is less likely to be a direct cause of hematuria, it can lead to related conditions.
Causes of Hematuria in Children
Visible and microscopic blood in children's urine can indicate a medical condition or a risk of developing one.
- Urinating more often than usual
- Painful urination
- Fever
- Abdominal pain or masses
- Pain in the sides
- Cola-colored urine
- High blood pressure
- Swelling
- Hearing loss
- Eye abnormalities
- Skin rashes
- Joint inflammation
- Fatigue
- Easy bruising
- Hemarthrosis
- Bleeding gums
- Bleeding joints, causing pain, reduced movement, warmth, and swelling
- Polycystic kidney disease
- Kidney stones
- Hereditary nephritis
- Alport syndrome
- Sickle cell disease
- Kidney cysts
Symptoms That Accompany Blood in Your Urine
Regardless, consulting your doctor anytime your urine is discolored can help you determine whether the change is harmless or more serious.
- Discomfort or pain while urinating
- Urgent need to urinate
- Frequent need to urinate
- Unexpected or unexplained weight loss
- Inability to urinate
- Fever
- Nausea or vomiting
- Abdominal pain
- Chills
Diagnosing the Cause of Blood in Urine
- Antinuclear antibody test
- Blood creatinine level
- Kidney biopsy
- Complete blood count
- Strep test
- Blood disorder tests
- Coagulation tests
- Blood chemistry tests
- 24-hour urine collection
“Many doctors and patients underestimate the importance of searching for a cause for blood in the urine,” says Anne Schuckman, MD, an associate professor of urology and urologic oncology at the Keck School of Medicine at the University of Southern California in Los Angeles. She recommends that a urologist evaluate any patients with hematuria.
“Infection can cause blood, but unfortunately, many patients who have blood in the urine may also have some white cells in the urine and receive treatment for a presumed urinary tract infection,” Dr. Schuckman says. “The antibiotics may help for a while. However, a serious underlying cause of the blood may be missed without a full investigation.”
Schuckman notes that new guidelines support less intense workups for patients who are younger and do not have a smoking history, allowing many patients to forgo a cystoscopy and get a molecular urine test instead. “Others may need imaging studies such as an ultrasound or a CT scan,” says Schuckman. “If people have a significant smoking history, it remains very important to undergo a direct look into the bladder using a cystoscopy to rule out serious issues such as bladder cancer.”
Treating the Causes of Hematuria
The Takeaway
- True hematuria (blood in your urine) may be a sign of an underlying medical condition, such as a urinary tract infection, kidney or bladder stones, endometriosis, an enlarged prostate, or cancer of the kidneys, bladder, or urethra.
- Some blood in your urine is normal during the menstrual cycle, as it does not originate from the urinary tract, and certain foods can change the color of urine.
- Hematuria can occur due to certain medications and strenuous exercise.
- If you have blood in your urine and symptoms like painful or frequent urination, fever, weight loss, or abdominal pain, speak with a healthcare professional.
Resources We Trust
- Cleveland Clinic: Hematuria
- American Kidney Fund: Blood in Urine (Hematuria) Causes and Treatment
- Cincinnati Children’s: Hematuria in Kids: What Does It Mean?
- Jefferson Health: There’s Blood in My Urine. Is It Serious?
- Urology Care Foundation: The Meaning Behind the Color of Urine
- Blood in urine (hematuria) causes and treatment. American Kidney Fund. July 17, 2025.
- Blood in urine (hematuria): Symptoms & causes. Mayo Clinic. December 24, 2025.
- Hematuria: Blood in the urine. Iowa Health Care. November 2020.
- Urine - bloody. MedlinePlus. July 1, 2025.
- Kidney Stones. Mayo Clinic. April 4, 2025.
- Hematuria (Blood in the Urine) in Children. National Kidney Foundation. February 21, 2025.
- Kallash M et al. Approach to Persistent Microscopic Hematuria in Children. Kidney360. July 10, 2020.
- Thin Basement Membrane Disease. National Kidney Foundation.
- Blood in urine (hematuria): Symptoms & causes. Mayo Clinic. December 24, 2025.
- Hematuria. Cleveland Clinic. January 14, 2025.
- Blood in urine (hematuria): Diagnosis & Treatment. Mayo Clinic. December 24, 2025.

Christopher Wolter, MD
Medical Reviewer
Christopher Wolter, MD, is an assistant professor in urology at Mayo Clinic in Phoenix, Arizona. He has been in practice since 2008, specializing in the areas of urinary incontinence, pelvic organ prolapse, urologic reconstruction, urologic prosthetics, post prostate cancer survivorship, erectile dysfunction, neurourology and neuromodulation, and overall functional considerations of urogenital health.
Dr. Wolter has been heavily involved in urologic education. He spent the last 12 years heavily involved in resident education and leadership for his department, including the last eight years as urology residency program director. He currently serves as the director of urologic education for the preclinical and clinical rotations for the Mayo Clinic Alix School of Medicine Phoenix, Arizona, campus.
Wolter completed his undergraduate and medical education at the University of Illinois. He then completed his urology residency at Tulane University in New Orleans, followed by a fellowship in female pelvic medicine and reconstructive urology at Vanderbilt University in Nashville, Tennessee.
