Palliative Care for Metastatic Prostate Cancer: Symptom Relief and Support

Palliative Care for Metastatic Prostate Cancer: How to Find Symptom Relief and Support

Palliative Care for Metastatic Prostate Cancer: How to Find Symptom Relief and Support
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If you or a loved one has metastatic prostate cancer, slowing the cancer progression isn’t the only concern. Dealing with the pain, nausea, fatigue, and other side effects of this cancer and its treatments must also be considered.

That’s where palliative care can help. It’s supportive care, given alongside treatments like hormone therapy and chemotherapy, that helps with symptom relief in metastatic prostate cancer. "It’s a mix of medications and other treatment approaches to try to reduce pain and other symptoms, including things like nausea and vomiting, constipation, anxiety, and stress," says Alicia Morgans, MD, MPH, a genitourinary medical oncologist and the director of the survivorship program at Dana-Farber Cancer Institute in Boston.

This supportive program isn’t just for prostate cancer patients, either. Their caregivers can also benefit from palliative care. It can connect them with the resources they need to take better care of their loved one — and themselves.

Palliative vs. Hospice Care

Even though palliative care can make daily life more manageable during cancer treatment, not everyone takes advantage of it. According to some estimates, only 14 percent of people who need this type of care actually receive it.

You don’t have to wait until your symptoms become unbearable to ask for palliative care. You can start at any time, from the day you’re diagnosed.
— Andrew Esch, MD

Martin Gugino, who was diagnosed with metastatic prostate cancer in 2015, has never officially been in a palliative care program, but he has taken anti-nausea drugs and other medications to lessen the side effects of his treatments. He has a theory about why more men don't take advantage of this program. "I think a lot of people confuse it with hospice, and they won't try it for that reason," he says.

One survey found that, among 3,000 respondents, only 11 percent had an adequate understanding of palliative care.

 Even some doctors mistakenly assume their patients have to be near the end of life to receive palliative care, "so the referrals aren't made," says Andrew Esch, MD, a senior education adviser at the Center to Advance Palliative Care in New York City.

Although palliative care and hospice care are both focused on improving quality of life for people with cancer, these two programs are not the same. Hospice care is used at the end of life — generally when someone has six months or less to live, and they have stopped receiving treatments to slow their cancer. Palliative care happens during prostate cancer treatment.

Palliative Treatments for Metastatic Prostate Cancer

These are a few of the palliative treatments that doctors recommend for managing symptoms of advanced prostate cancer.

Anti-Nausea Medications

Nausea and vomiting are common side effects of chemotherapy. To manage this symptom, you might first try lifestyle changes such as eating smaller meals, drinking more fluids, and avoiding foods that upset your stomach.

If those measures don't work, your doctor can prescribe an antiemetic medication like ondansetron (Zofran). It works by blocking the chemical serotonin, which triggers nausea.

Exercise

Fatigue can be one of the most debilitating symptoms of advanced prostate cancer because it prevents you from doing the things you want to do. "I think graded exercise is probably the most effective treatment for fatigue," Esch says. With this therapy, you start exercising slowly and gradually increase your effort over time.

"Try walking to the mailbox and do that a few days in a row," he suggests. "Then see if you can walk to the mailbox twice. Then see if you can walk three or four houses down." Keep a log to track your progress.

Pain Medications

Not every man with metastatic prostate cancer will have pain. But when pain does occur, it's often because the cancer has spread to the bones or is pressing on nerves.

Doctors often try to minimize the use of opioid pain relievers because of side effects like drowsiness and the potential for addiction. Instead, for advanced prostate cancer pain management, they may prescribe anti-inflammatory drugs like steroids or nonsteroidal anti-inflammatory drugs (NSAIDs). Bisphosphonates also reduce bone pain by slowing bone breakdown and preventing fractures.

For the type of shooting pain triggered by the tumor pressing on a nerve, drugs for nerve pain like gabapentin (Neurontin) or pregabalin (Lyrica) may be helpful. Muscle relaxants are good for easing muscle spasms. And lidocaine patches and creams or heating pads can be helpful for relaxing the muscles around the bone area.

Radiation

Radiation won't cure metastatic prostate cancer, but it can shrink tumors enough to relieve bone pain. A type of radiation therapy called stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiotherapy (SABR), aims a very precise beam of radiation at specific areas of bone that contain cancer.

Another option is to take a radioactive drug like radium-223 (Xofigo) that works inside your body to shrink cancer in your bones. Dr. Morgans says radiation helps 70 to 80 percent of her patients and allows some of them to cut down on or avoid narcotic pain medications.

Relaxation Techniques

Living with advanced prostate cancer is stressful. Deep breathing, progressive muscle relaxation, and guided imagery are just some of the relaxation methods that can help ease that stress. There’s evidence that these techniques can help ease symptoms and improve coping skills in cancer patients.

Surgery

In early-stage prostate cancer, the goal of surgery is to cure the cancer. In advanced prostate cancer, it's more about symptom relief. A procedure called transurethral resection of the prostate (TURP) removes cancer that’s blocking the urethra and making it hard to urinate.

 Surgery is also done to fix a bone that cancer has weakened to the point of fracture.

Talk Therapy

Therapy can be a powerful tool for managing the stress of advanced prostate cancer. A social worker, therapist, or counselor from your palliative care team can offer advice and help you work through any issues you're having. They can also help you deal with sexual health and intimacy issues that arise during prostate cancer treatment.

A review published in 2024 found one type of therapy called cognitive behavioral therapy (CBT) helpful for improving depression, anxiety, and quality of life in prostate cancer survivors. This treatment also improved participants' sexual function, including their desire and sexual satisfaction.

How to Get Palliative Care

You don't have to wait until your symptoms become unbearable to ask for palliative care. You can start at any time, from the day you're diagnosed, says Esch.

If your oncologist or cancer hospital doesn't suggest palliative care, ask about it. Not every cancer hospital offers this program, but resources may be available in your community. "If you can't find anything and you speak to your local hospice, they may be able to point you in the direction of a palliative care group," Morgans says. You can also search for a program in your area through the Get Palliative Care Provider Directory.

It's worth asking for palliative care when you're diagnosed with advanced prostate cancer. This program can give you relief from pain, stress, and other symptoms, and let you focus on controlling your cancer.

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
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  3. Managing Nausea and Vomiting at Home. American Cancer Society. June 26, 2024.
  4. Managing Pain in Advanced Prostate Cancer. Prostate Cancer UK. March 2026.
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  6. About Mind-Body Therapies. Memorial Sloan Kettering Cancer Center.
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  9. Pieramico S et al. A Systematic Review on the Efficiency of CBT Interventions for the Mental and Sexual Health of Survivors of Prostate Cancer. Sexual Medicine Reviews. January 2024.

Tingting Tan, MD, PhD

Medical Reviewer

Tingting Tan, MD, PhD, is a medical oncologist at City of Hope National Medical Center.

Dr. Tan's research has been published in multiple medical and scientific journals, including...

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Stephanie Watson

Author
Stephanie Watson is a freelance health writer who has contributed to WebMD, AARP.org, BabyCenter, Forbes Health, Fortune Well, Time, Self, Arthritis Today, Greatist, Healthgrades, ...