Signs You Should Change Your Postpartum Depression Treatment

5 Signs You Should Change Your Postpartum Depression Treatment

5 Signs You Should Change Your Postpartum Depression Treatment
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Treatment options for postpartum depression (PPD) may include psychotherapy (talk therapy), medication, lifestyle changes, or a combination of these approaches. The right treatment can take some trial and error to find, and what works well for one person may not be the right fit for another.

Your first treatment plan may not be your final one, and your healthcare provider may make adjustments along the way. They may do this if your symptoms aren’t improving or are worsening, if a prescribed medication is causing difficult side effects, or the type of therapy you’re receiving isn’t resonating with you.

Here are five signs it may be time to talk with your healthcare provider about adjusting your PPD treatment. Don’t stop a medication, change your dose, or alter your treatment plan on your own without consulting your healthcare team first.

1. Symptoms Aren’t Improving — or Are Getting Worse

Antidepressants — often paired with psychotherapy — are the first-line treatment option for moderate to severe PPD.

Antidepressants aren’t an overnight fix, and it’s important to give them time to work. But you should notice improvements, such as better sleep or a boost in energy, within the first few weeks, and noticeable improvements in mood and daily functioning within four to eight weeks.

If you’ve given medication a few weeks to take effect and your symptoms haven’t improved, it’s worth speaking up, says Laudy Burgos, LCSW, a board member of Postpartum Support International and the associate director of social work in the women’s and children’s division at Mount Sinai Hospital in New York City.

“If you tell me six to eight weeks into treatment that how you’re feeling is the same, that’s not a good sign,” Burgos says.

Not everyone with PPD finds that their symptoms respond fully to their first prescribed medication. A review of clinical trials of antidepressants for PPD found that, for selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed antidepressants and first choice for PPD, reported response rates ranging from 43 to 87 percent and remission rates ranging from 37 to 65 percent after six to eight weeks of treatment.

There’s also an important caveat when medication is involved: Medication hasn’t necessarily “failed” unless it’s been taken at an appropriate therapeutic dose for long enough to have its intended effect, says Lulu Zhao, MD, an obstetrician-gynecologist and the codirector of women's behavioral health at the Cleveland Clinic, where she specializes in mood disorders during key reproductive transitions, such as pregnancy and postpartum. Starting doses are often intentionally lower to limit initial side effects, which are common with antidepressants, and your provider will likely increase your dose shortly afterward, she says.

If you’re not feeling better after several weeks or months, let your doctor know. They can help you determine whether you need to give the medication more time to work, a dosage adjustment, another medication, or a completely different approach.

And if your symptoms suddenly worsen at any point after starting a medication, especially if you feel significantly more anxious or unable to sleep, tell your doctor immediately. Those may be signs it might not be the right medication for you. “If you’re telling me you’re sadder, you’re more anxious, you’re more hopeless, you’re having difficulty functioning, or you can barely function, that’s concerning,” Burgos says.

2. You Feel Better — but Only Partially

Feeling better is encouraging, but some improvement doesn’t mean your PPD is fully treated. If you’re noticeably better but still experiencing sadness, anxiety, difficulty coping, or other lingering symptoms, tell your healthcare provider.

The goal is to reach remission, Zhao says. That means symptoms have fallen into a nondepressed range on validated screening questionnaires, which are tools that help providers assess the severity of their patients’ depressive symptoms.

In day-to-day terms, that looks like being able to go about your normal activities and no longer having significant lingering depressive symptoms, she says.

“You’re not in remission just because you’re better than you were,” Zhao says. For example, she says, she often sees patients who return to their usual responsibilities, but feel like small stressors may be enough to worsen their PPD symptoms. “You shouldn’t feel like you’re functioning but like it takes just one thing to break the camel’s back,” she says.

That said, this doesn’t mean you should abandon a treatment plan that’s helping. Instead, your provider may recommend continuing it longer or adjusting part of the plan to help you reach full recovery. In some cases, this may involve adding resources, such as a support group with other postpartum moms, rather than replacing what’s working, Burgos says.

Zhao generally advises being in remission for at least six months before stopping treatment to prevent a relapse of PPD symptoms.

3. Medication Side Effects Are Hard to Tolerate

Side effects are common when starting antidepressants. With selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed antidepressants, you may encounter gastrointestinal upset, increased anxiety or feeling “amped up,” and vivid dreams, Zhao says.

It’s always a good idea to tell your doctor about any initial side effects you have. Some are mild and often improve after you’ve taken the medication consistently for two to three weeks. Others are more significant, may linger, and may signal that the medication might not be right for you. In terms of side effects that can persist, some people experience fatigue, sedation, sexual dysfunction, muscle aches, or other symptoms that become difficult to live with, says Zhao.

“When you have persistent side effects that don’t seem to be an initiation side effect and that can’t be ameliorated by treatment tweaking, that might be a sign that you should try a different medicine,” she says.

Don’t make changes to your medication yourself. “I do recommend that you talk to your doctor before you decide yourself to stop something,” Zhao says. Sometimes, an adjustment as simple as changing the time of day you take the medication may address a problem.

4. Therapy Isn’t Resonating With You

The relationship you have with your therapist matters. In some cases, you may feel like your therapist isn’t listening, their style doesn’t suit you, or the specific type of therapy isn’t clicking.

“The first psychotherapist you find is not necessarily the best match for you, and that’s just like medicine,” Zhao says. “If the first medicine doesn’t work, you should try a different medicine or a different therapist.”

For PPD, Burgos often recommends cognitive behavioral therapy (CBT) and interpersonal therapy (IPT), which are evidence-based therapies for depression and other mental health conditions.

But someone may not like the homework involved with CBT, or they might not connect with the IPT approach. If you don’t feel like those approaches are helping you, other evidence-based therapies like couples therapy, family therapy, or eye movement desensitization and reprocessing (EMDR) therapy are also options, Zhao says.

Before immediately switching your therapist or type of therapy, consider telling your therapist what you feel isn’t working. “If you don’t like the way your therapist is approaching things, you think they’re not giving you enough directed guidance, you think they’re too validating, not validating enough, you should just tell them directly,” Zhao says.

Sometimes adjustments can be made between a provider and patient. If it still doesn’t feel right, changing therapists or trying another form of therapy may make sense for you.

5. You’re Having Thoughts of Suicide, Self-Harm, or Harming Your Baby

Thoughts about death or suicide, urges to self-harm, or thoughts of harming your baby require immediate medical attention.

“If someone wants to hurt themselves or they’re talking about harming their baby, to me, that’s a psychiatric emergency,” Burgos says. “And it requires immediate treatment. That is not something that I would wait to see my therapist in a few days or next week.”

If you have a history of major depressive disorder or another mental health condition, you may have an increased risk for postpartum psychosis, a mental health emergency that causes a person to feel detached from reality. Symptoms of postpartum psychosis, such as hallucinations, paranoia, or thoughts that seem bizarre or disconnected from reality, also require urgent medical help.

You shouldn’t have to determine how serious the situation is on your own; err on the side of caution, says Zhao. “If you feel you’re experiencing psychosis or hallucinations or thoughts that seem bizarre to you, you should let a medical professional know,” she says.

In severe cases, a higher level of treatment may be necessary. Options can include inpatient hospitalization, intensive outpatient programs, or partial hospitalization programs, depending on a person’s symptoms and safety needs, says Burgos.

Crisis Prevention

If you or a loved one is experiencing significant distress or having thoughts about suicide and needs support, call or text 988 to reach the 988 Suicide & Crisis Lifeline, available 24/7.

For more help and information, see these Mental Health Resources and Helplines.

Resources We Trust

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Carlson K et al. Perinatal Depression. StatPearls. January 22, 2025.
  2. Chen Y et al. Risk Factors for Treatment Resistance Among Women with Postpartum Depression in a Nationwide Study. Nature Mental Health. February 4, 2026.
  3. Assessment and Treatment of Perinatal Mental Health Conditions. American College of Obstetricians & Gynecologists.
  4. Antidepressants. Mayo Clinic. August 29, 2025.
  5. Postpartum Depression. Anxiety & Depression Association of America.
  6. Postpartum Depression: Symptoms & Causes. Mayo Clinic. November 24, 2022.
  7. Postpartum Psychosis. Cleveland Clinic. September 13, 2022.
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Allison Young, MD

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Allison Young, MD, is a board-certified psychiatrist providing services via telehealth throughout New York and Florida.

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