Flu-Like Illnesses Hit 30-Year High — Is It Too Late to Get a Flu Shot?

This flu season seems to be going from bad to worse.
The percentage of flu tests coming back positive jumped by 33 percent over the previous week, and about 11 million cases total have already been recorded this flu season.
“It looks like we are in for a rough flu season,” says Mark Rupp, MD, an infectious disease specialist and the interim chair of the department of internal medicine at the University of Nebraska Medical Center in Omaha. “Influenza-like illness trends are sharply up and we probably have a few weeks before flu peaks.”
Flu Has Already Killed 5,000 People in the U.S.
While most people get through the flu with about a week of rest, fluids, and care, many have much more severe illness. Already this season, flu has led to 120,000 hospitalizations and 5,000 deaths.
“Flu usually involves the upper airways, but when it gets into the lungs, it can turn deadly,” says Dr. Rupp. “This is particularly true for those who have certain risk factors, such as old age [those over 65], underlying cardiorespiratory disease, or immunosuppression.”
Sojib Zaman, PhD, an assistant professor of health sciences at James Madison University in Harrisonburg, Virginia, warns that in some instances, even seemingly healthy people can become seriously ill or die from flu.
“Sometimes the virus causes severe lung injury very quickly, or a secondary bacterial infection [usually pneumonia] strikes,” he says. “Also, ‘healthy’ people may have risk factors that they do not realize they have, and delays in seeking care or antivirals can matter.”
A New Flu Mutation Is Driving the Surge
A rise in flu activity can be expected this time of year due to holiday travel and children going back to school, spreading respiratory viruses to classmates and taking the infection home to others.
A major factor adding fuel to the fire this season, however, is an unexpected mutation in the flu virus that allows it to better evade any immune defenses. A new version of influenza A (H3N2) called subclade K is highly contagious and accounts for the vast majority of influenza cases in all parts of the United States and across the Northern Hemisphere, according to Andrew Pekosz, PhD, a virologist with the division of infectious diseases at Johns Hopkins Bloomberg School of Public Health in Baltimore.
Although some have called this strain a “super flu,” Dr. Pekosz considers the label misleading as there is no evidence at this time indicating that subclade K causes more severe illness.
“The rate of hospitalization appears quite consistent with that of other influenza seasons; it’s just that this virus is causing a lot more infections, and we are seeing a proportional rise in severe cases,” he says.
Vaccine Is Not a Perfect Match but Provides Significant Protection
Many months ago, when manufacturers decided on the formula for this season’s vaccine, subclade K was not yet on the radar, so this year’s shot is considered somewhat of a mismatch.
“The K subclade has ‘genetically drifted’ from the H3N2 strain that is in the flu vaccine, so this could be contributing to the number of cases,” says Rupp.
Still, because the vaccine contains components that protect against the H3N2 strain in general, the shot is expected to provide significant protection against serious illness.
Samantha Picking, PharmD, the senior director of immunizations for the pharmacy chain Walgreens, views low vaccination rates as contributing to higher than usual flu cases.
“Vaccination rates continue to lag in comparison to pre-pandemic years,” she says. “When fewer individuals are vaccinated, we lose the benefits of herd immunity, which helps protect vulnerable groups and limit the overall spread of the virus.”
Is It Too Late to Get a Flu Shot?
Dr. Picking adds that it’s not too late to get vaccinated as flu season typically lasts into the spring. But getting the shot sooner than later is recommended as it takes about two weeks for it to become fully effective.
Along with vaccination, the following measures can also help reduce flu transmission:
- Wash hands frequently.
- Avoid touching your face.
- Stay home if you’re sick and stay away from those who are sick.
- Wear a well-fitted N95 mask (especially if you are in a high-risk group) when in enclosed spaces with other people, such as on airplanes or mass transit.
- If you get sick, check with your pharmacy or doctor about getting influenza antiviral drugs, as they can help you feel better and reduce your risk of severe disease if taken within 48 hours of symptom onset.
- Weekly US Influenza Surveillance Report: Key Updates for Week 52, ending December 27, 2025. Centers for Disease Control and Prevention. January 5, 2025.
- National, Regional, and State Level Outpatient Illness and Viral Surveillance. FluView Interactive. December 27, 2025.
- Hajjar S et al. The First Influenza Pandemic of the 21st Century. Annals of Saudi Medicine. January-February 2010.
- Jenco M. CDC: 9 Children Have Died of Flu This Season; Previous Season Sets Record. American Academy of Pediatrics. January 6, 2026.
- Ferdinands J et al. Does Influenza Vaccination Attenuate the Severity of Breakthrough Infections? A Narrative Review and Recommendations for Further Research. Vaccine. June 23, 2021.
- Vaccination Trends. Centers for Disease Control and Prevention. January 5, 2026.

Emily Kay Votruba
Fact-Checker

Don Rauf
Author
Don Rauf has been a freelance health writer for over 12 years and his writing has been featured in HealthDay, CBS News, WebMD, U.S. News & World Report, Mental Floss, United Press International (UPI), Health, and MedicineNet. He was previously a reporter for DailyRx.com where he covered stories related to cardiology, diabetes, lung cancer, prostate cancer, erectile dysfunction, menopause, and allergies. He has interviewed doctors and pharmaceutical representatives in the U.S. and abroad.
He is a prolific writer and has written more than 50 books, including Lost America: Vanished Civilizations, Abandoned Towns, and Roadside Attractions. Rauf lives in Seattle, Washington.