The Connection Between E. Coli and Urinary Tract Infections (UTIs)

The Connection Between E. Coli and Urinary Tract Infections (UTIs)

The Connection Between E. Coli and Urinary Tract Infections (UTIs)
Adobe Stock (2)
Urinary tract infections (UTIs) are one of the most common types of bacterial infections, with more than 150 million diagnoses worldwide each year.

 E. coli (Escherichia coli) is responsible for 75 percent of all uncomplicated or classic UTIs, or infections of the lower urinary tract in otherwise healthy women. It is also in more than half of complicated cases, or those that affect other urinary-tract functions or occur in men, pregnant women, or people with weakened immune systems.

E. coli is normally found in your intestines, but it can enter your urinary tract and travel upward, potentially causing an infection in your bladder or kidneys. UTI symptoms alone can’t tell you whether E. coli or other bacteria is to blame, as many infections feel identical. A urine culture is the only reliable test to confirm if E. coli is in your urinary tract or if another organism is causing your UTI.

 Your doctor can work with you to guide the most effective treatment.

How Does E. Coli Enter Your Urinary Tract?

E. coli lives inside of us naturally and usually causes no harm. But some E. coli are pathogenic, meaning they can cause illness. Research has shown, for instance, that nearly 1 in 5 UTIs may come from a strain of E. coli present in meat.

With UTIs, E. coli bacteria from your intestines is present in fecal matter. And trace amounts of said fecal matter make their way into your urinary tract through the urethra opening and begin to multiply.

Women are more prone to having UTIs in general, as 60 percent may have a UTI in their lifetime.

 One of the reasons is that women have short urethras, so E. coli bacteria from the rectum doesn’t have a long distance to travel to reach the urethra and bladder to cause an infection.

Common ways in which this traveling or infection can happen include:

  • Sexual Contact A woman’s urethra is located next to the vagina and anus. This makes it easy for bacteria to move into the urinary tract during sexual intercourse and sexual contact.

  • Improper Wiping For women, wiping from back to front after a bowel movement can drag E. coli directly into the urethra. Because of this, it’s best to wipe from front to back.

  • Holding Urine Frequent bathroom use lets your body continue to flush bacteria such as E. coli from your system. This is especially important before and after sex. To encourage frequent urination, drink plenty of water throughout the day.

Other factors can raise your risk of a UTI, including:

  • Diabetes People with high blood sugar are not able to fight off germs and bacteria as well as others, making them more prone to UTIs.
  • Spinal Cord Injuries This type of nerve damage prevents you from being able to empty your bladder completely, thereby allowing E. coli bacteria to multiply.
  • Kidney Stones Having kidney stones or a condition that blocks the flow or urine, such as a tumor or an enlarged prostate, can trap urine in your bladder and contribute to a UTI or another infection.
  • Catheter Use Medical tubes placed in your urethra and bladder to remove urine can also trigger a UTI.
  • Recent Urinary Procedures If you’ve had urinary surgery or an exam of your urinary tract that involves medical instruments, you may be at an increased risk of getting a UTI.

7 Surprising Risk Factors for Urinary Tract Infections

Discover 7 surprising things that can increase your risk of getting a UTI.
7 Surprising Risk Factors for Urinary Tract Infections

UTIs From Antibiotic-Resistant E. Coli

Antibiotics are the first-line treatment for UTIs. But some strains of E. coli, including extended-spectrum beta-lactamase (ESBL) E. coli, have become more resistant to many of these drugs.

As many as one-third of these cases may be resistant to common antibiotics taken by mouth such as amoxicillin (Amoxil), levofloxacin, and trimethoprim-sulfamethoxazole (Bactrim, Septra).

People most at risk for drug-resistant E. coli UTIs include those with urinary catheters, anyone with a history of recurrent UTIs, and people who recently had a course of antibiotics.

Not only are drug-resistant infections harder to treat, but people who get these infections are also at an increased risk for a potentially life-threatening complication called sepsis.

 This happens when your body’s infection response damages tissues and organs.

“We used to think of a urinary tract infection as something that would be a bit of an annoyance,” says Jason Tetro, a microbiologist in Edmonton, Alberta, Canada, and author of The Germ Files and The Germ Code. “But if it’s antibiotic-resistant, then that means your standard regimen of antibiotics will not work, and then you have to start looking at going into much stronger antibiotics.”

   Poll

How quickly do you typically feel better after starting antibiotics for a UTI?

What Are the Symptoms of an E. Coli UTI?

Symptoms of a UTI can vary from person to person. Some people may have no symptoms at all. But for most, a UTI can be uncomfortable or even painful.

The only way to find out if the infection comes from E. coli in the urinary tract is through lab testing of a urine sample. Otherwise, symptoms of an E. coli UTI resemble those of infections with other causes, Tetro says.

“When you have a classic UTI, your symptoms can’t tell you what it is that’s causing it,” he says. “All it can tell you is that something’s not right and you want to go get that looked at.”

Some common UTI symptoms include:

  • Strong, persistent urge to urinate
  • Painful and burning urination
  • Passing only minimal amounts of urine
  • Strong-smelling, cloudy urine
  • Red or pink-tinged urine, which indicates blood is present
  • Pain in the upper back and sides
  • Fever and chills
  • Nausea or vomiting
  • Pelvic pressure
Medical Illustration of How a UTI Affects the Body, Man centered, surrounded by symptoms including chills, back or side pain, frequent urination, burning while urinating, passing less urine, cloudy or discolored urine, pelvic pain, nausea of vomiting
Urinary tract infections can cause multiple symptoms throughout your body.Everyday Health

Preventing E. Coli UTIs

While you can’t always prevent a UTI, you can lower your risk of getting a UTI caused by E. coli in the urinary tract with a few lifestyle changes.

“The best way to prevent it is really just to have good hygiene practices,” Tetro says.

These habits can include:

  • Drink plenty of fluids. Aim to drink six to eight glasses of water a day. Staying hydrated dilutes urine and helps flush bacteria from your urinary tract before an infection can take hold.

  • Practice good hygiene. If you’re a woman, try to always wipe from front to back after using the toilet to prevent bacteria from moving from your rectum to your urethra. During your period, change pads and tampons regularly.

  • Urinate often if you can. Pee frequently to help clear bacteria from your system. Empty your bladder right before and after sex, and drink a full glass of water to help flush out bacteria.

  • Consider trying cranberry products. While research is mixed, drinking cranberry juice or taking extract supplements may help some people reduce their UTI risk. These products are generally safe for most people, but it’s wise to talk to your doctor before turning to this option.

  • Avoid using certain birth control methods. Use of diaphragms, unlubricated condoms, and condoms with spermicide can increase the risk of infection.

  • Wear breathable clothing. Wearing tight-fitting pants or underwear can trap moisture and encourage bacterial growth. Opt for loose-fitting clothes and cotton underwear instead.

  • Talk to your doctor about medications. If you’re in postmenopause, you may benefit from vaginal estrogen cream, which helps rebalance vaginal pH. Your healthcare provider may also recommend probiotics or other supplements to support urinary health.

Treating E. Coli UTIs

Antibiotics are the first line of treatment for UTIs. Which one your doctor prescribes will be based on the type of bacteria found in your urine.

Uncomplicated UTIs may resolve after a few days once you take medication, Tetro says. Complicated or severe UTIs may take longer or require intravenous antibiotics in a hospital.

The Takeaway

  • E. coli is responsible for as much as 75 percent of all uncomplicated urinary tract infections and can enter the urinary tract via fecal matter, sexual activity, improper wiping, or other ways.
  • The only way to tell if a UTI is from E. coli is from a urine sample, as symptoms may resemble infections from other bacteria.
  • Although most uncomplicated UTIs can resolve within a few days with antibiotics, some UTIs are resistant to antibiotics — and complicated UTIs may require other treatments and more time to go away.
  • Preventing E.coli-triggered UTIs focuses on hygiene and lifestyle habits. Aim to drink plenty of water, wipe from front to back, urinate before and after sex, and avoid certain birth-control methods.

Resources We Trust

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Ackerson BK et al. Risk Factors for Recurrent Urinary Tract Infections Among Women in a Large Integrated Health Care Organization in the United States. The Journal of Infectious Diseases. November 15, 2024.
  2. Zhou Y et al. Urinary Tract Infections Caused by Uropathogenic Escherichia coli: Mechanisms of Infection and Treatment Options. International Journal of Molecular Sciences. June 2023.
  3. Bono MJ et al. Uncomplicated Urinary Tract Infections. StatPearls. February 21, 2025.
  4. Aziz M et al. Zoonotic Escherichia Coli and Urinary Tract Infections in Southern California. Clinical Microbiology. October 23, 2025.
  5. Urinary Tract Infection (UTI). Mayo Clinic. September 26, 2025.
  6. What Causes UTIs and UI? National Institutes of Health. May 5, 2022.
  7. Mareș C et al. Update on Urinary Tract Infection Antibiotic Resistance — A Retrospective Study in Females in Conjunction with Clinical Data. Life. January 9, 2024.
  8. Miftode IL et al. The Impact of Urinary Catheterization on the Antibiotic Susceptibility of ESBL-Producing Enterobacterales: A Challenging Duo. Antibiotics. May 17, 2024.
  9. Shao Y et al. Related Factors of Bloodstream Infections Associated With Urinary Tract Infections and Pathogenetic Characteristics Analysis. European Journal of Medical Research. November 29, 2024.
  10. Urinary Tract Infections. Cleveland Clinic. April 6, 2023.
  11. Williams G et al. Cranberries for Preventing Urinary Tract Infections. Cochrane Database of Systematic Reviews. November 10, 2023.
  12. Urinary Tract Infections. Cleveland Clinic. April 6, 2023.

Christopher Wolter, MD

Medical Reviewer

Christopher Wolter, MD, is an assistant professor in urology at Mayo Clinic in Phoenix, Arizona. He has been in practice since 2008, specializing in the areas of urinary incontinence, pelvic organ prolapse, urologic reconstruction, urologic prosthetics, post prostate cancer survivorship, erectile dysfunction, neurourology and neuromodulation, and overall functional considerations of urogenital health.

Dr. Wolter has been heavily involved in urologic education. He spent the last 12 years heavily involved in resident education and leadership for his department, including the last eight years as urology residency program director. He currently serves as the director of urologic education for the preclinical and clinical rotations for the Mayo Clinic Alix School of Medicine Phoenix, Arizona, campus.

Wolter completed his undergraduate and medical education at the University of Illinois. He then completed his urology residency at Tulane University in New Orleans, followed by a fellowship in female pelvic medicine and reconstructive urology at Vanderbilt University in Nashville, Tennessee.

Holly Pevzner

Holly Pevzner

Author

Holly Pevzner is a writer who specializes in health, nutrition, parenting, and pregnancy. She is currently a staff writer at Happiest Baby. Her work, including essays, columns, features, and more, spans a variety of publications, websites, and brands, such as EatingWell, Family Circle, Fisher-Price, Parents, Real Simple, and The Bump. Pevzner has written several monthly health columns, including for First for Women and Prevention magazines. She previously held senior staff positions at Prevention, Fitness, and Self magazines, covering medical health and psychology. She was also a contributing editor at Scholastic's Parent & Child magazine.

carmen-chai-bio

Carmen Chai

Author

Carmen Chai is a Canadian journalist and award-winning health reporter. Her interests include emerging medical research, exercise, nutrition, mental health, and maternal and pediatric health. She has covered global healthcare issues, including outbreaks of the Ebola and Zika viruses, anti-vaccination movements, and chronic diseases like obesity and Alzheimer’s.

Chai was a national health reporter at Global News in Toronto for 5 years, where she won multiple awards, including the Canadian Medical Association award for health reporting. Her work has also appeared in the Toronto Star, Vancouver Province, and the National Post. She received a bachelor’s degree in journalism from Ryerson University in Toronto.