Rybelsus (Semaglutide (Oral/Injection))
This medication guide is specific to Rybelsus.
Semaglutide oral is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.
Semaglutide oral may also be used for purposes not listed in this medication guide.
uses
What is Rybelsus (Semaglutide (Oral/Injection)) used for?
- Diabetes Type 2
- Weight Loss
- Diabetes Mellitus
- Diabetic Coma (in DM Type II)
- Diabetic Ketoacidosis (in DM Type II)
- Cardiovascular Risk Reduction
warnings
What is the most important information I should know about Rybelsus (Semaglutide (Oral/Injection))?
You should not use semaglutide oral if you are allergic to it, or if you have or have ever had:
- multiple endocrine neoplasia type 2 (tumors in your glands); or
- a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer).
Tell your doctor if you have or have ever had:
- a severe stomach problem such as problems with digesting food or slowed emptying of your stomach (gastroparesis);
- pancreas disorder;
- a planned surgery or a medical procedure;
- eye problems caused by diabetes; or
- kidney disease.
It is not known if semaglutide oral will harm an unborn baby. You should stop using this medicine at least 2 months before you plan to become pregnant. Ask your doctor for a safer medicine to use during this time. Controlling diabetes is very important during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breastfeed while using this medicine.
Side Effects
What are the side effects of Rybelsus (Semaglutide (Oral/Injection))?
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- vision changes;
- severe stomach problems--diarrhea or constipation;
- signs of a thyroid tumor--swelling or a lump in your neck, trouble swallowing, a hoarse voice, feeling short of breath;
- pancreatitis or gallbladder problems--severe pain in your upper stomach spreading to your back, nausea and vomiting, chalky-colored stools, stomach pain after eating, heartburn, and bloating;
- low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or
- kidney problems--swelling, urinating less, feeling tired or short of breath.
Common side effects may include:
- nausea, vomiting, stomach pain, loss of appetite; or
- diarrhea, constipation.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Rybelsus (Semaglutide (Oral/Injection)) if I’m pregnant or breastfeeding?
It is not known if semaglutide oral will harm an unborn baby. You should stop using this medicine at least 2 months before you plan to become pregnant. Ask your doctor for a safer medicine to use during this time. Controlling diabetes is very important during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breastfeed while using this medicine.
Interactions
What drugs and food should I avoid while taking Rybelsus (Semaglutide (Oral/Injection))?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Rybelsus (Semaglutide (Oral/Injection))?
Use Rybelsus (Semaglutide (Oral/Injection)) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using exactly as directed on the label, or as prescribed by your doctor.
Semaglutide oral is usually taken once per day. Follow your doctor's instructions.
Take on an empty stomach in the morning with water (no more than 4 ounces). Wait at least 30 minutes before you eat, drink, or take any oral medicines.
Swallow the tablet whole and do not crush, chew, or break it.
Blood sugar can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals.
Low blood sugar (hypoglycemia) can make you feel very hungry, dizzy, irritable, or shaky. To quickly treat hypoglycemia, eat or drink hard candy, crackers, raisins, fruit juice, or non-diet soda. Your doctor may prescribe glucagon injection in case of severe hypoglycemia.
If you need surgery or any medical procedure, tell the doctor ahead of time that you are taking semaglutide oral. You may need to stop using the medicine for a short time.
Tell your doctor if you have frequent symptoms of high blood sugar (hyperglycemia) such as increased thirst or urination. Ask your doctor before changing your dose or medication schedule.
Call your doctor if your symptoms do not improve, or if they get worse.
Your treatment may also include diet, exercise, weight control, medical tests, and special medical care.
You may get dehydrated during prolonged illness. Call your doctor if you are sick with nausea, vomiting or diarrhea, or if you eat or drink less than usual.
Store the medicine in the original package at room temperature, away from moisture and heat.
Skip the missed dose and take your next dose at the regular time. Do not take two doses in one day.
Overdose Signs
What happens if I overdose on Rybelsus (Semaglutide (Oral/Injection))?
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