7 Ways Creatine Could Benefit Your Body and Mind

7 Potential Health Benefits of Creatine

7 Potential Health Benefits of Creatine
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Note: The U.S. Food and Drug Administration (FDA) does not approve supplements for safety or effectiveness. Talk to a healthcare professional about whether a supplement is the right fit for your individual health, and about any potential drug interactions or safety concerns.

Creatine is a natural substance made from amino acids by the liver, kidneys, and pancreas, and it’s found in the muscles and brain.

 Its main function is to transport energy in the body’s cells, says Michael Roberts, PhD, a professor in the School of Kinesiology at Auburn University in Alabama.

Creatine supplements are often associated with better physical strength, but they may also offer a host of other health benefits that assist the body’s mental and emotional needs.

1. It May Boost Physical Performance

Creatine is a popular supplement for athletes and weight lifters because the extra energy boost it provides may allow them to squeeze out a few extra reps, lift a bit heavier, or go a little longer and harder.

“Creatine may increase strength, [muscle size], and performance, especially in high-intensity intermittent activities like sprints, weight lifting, and team sports,” says Heidi Skolnik, CDN, a fellow of the American College of Sports Medicine, based in Englewood Cliffs, New Jersey.

Creatine is one of the most extensively studied nutritional supplements for athletic performance:

  • Research finds that creatine supplements may increase how much physical exertion a person can maintain, including during sports such as sprinting, swimming, and cycling.

  • Creatine may increase endurance and performance during workouts that require low-intensity movements mixed with repeated bursts of high-intensity activity, such as mountain biking or triathlons.

  • Creatine supplementation has also been shown to boost muscle growth in healthy young adults, though the effects are less clear in other groups, such as those who are older or who have health conditions.

  • It has also been shown to increase strength when combined with resistance training, particularly in men under 50. Those same benefits were not seen in women.

“Creatine can benefit almost all if not all athletes, no matter what sport they are doing, making it a popular supplement,” says Shelley Balls, RDN, who is based in Smoot, Wyoming.

2. It May Enhance Exercise Recovery

The evidence about whether creatine can help with post-workout soreness or injury healing is promising, especially in younger, fit adults.

Healthy men ages 21 to 36 who supplemented with creatine for recovery from dumbbell exercises saw faster recovery of range of motion, better strength retention, less muscle swelling, less muscle stiffness, and less muscle fatigue than those who did not take creatine, according to a small study of 20 men.

Creatine may also have antioxidant and anti-inflammatory effects in the body, which may speed up post-exercise recovery after endurance workouts.

Illustrative graphic titled Potential health benefits of Creatine Graphic shows may help build muscle, boost athletic performance, may help improve muscle recovery and help support cognitive function. Everyday Health logo
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3. It May Reduce Body Fat

The lean muscle that creatine helps create can help speed up the body’s metabolism. In a meta-analysis of studies involving more than 600 adults ages 50 and older, those who took creatine supplements during resistance training had a greater reduction in body fat percentage than those who took a placebo.

“Creatine supplementation doesn’t just benefit athletes — it provides positive benefits to recreational fitness enthusiasts, as well as younger and older individuals,” says Balls.

In another review of 266 adults under 50, the fat-burning benefits of creatine were less clear. The combination of resistance exercise and creatine supplementation led to a small reduction in body fat percentage among study participants, which reflects gains in lean muscle mass rather than a reduction in fat mass.

4. It May Help Boost Mood

Creatine may lower symptoms of depression, especially when it’s paired with common antidepressants like SSRIs. It may help by boosting how the brain uses energy and its neuroplasticity. Supplementing with creatine for this mood disorder may not be right for everyone, including those with bipolar disorder. More studies are needed to determine the exact dose, its long-term efficacy, and how safe it is for different groups of people.

Women, in particular, may get mental benefits from this type of supplement. Research has shown that they have lower levels of creatine in the frontal lobe than men, which is the part of the brain that controls mood, cognition, memory, and emotion. Supplementation may boost these stores, leading to improvements in mood.

5. It May Improve Mental Fatigue

Some creatine research on mental fatigue has been conducted in athletes. One review found creatine supplements may improve performance in sports that demand motor control, decision-making, coordination, and reaction time.

 And a small study of 10 elite rugby players revealed that creatine supplementation reduced the effects of sleep deprivation on throwing accuracy.

“Research has provided intriguing evidence that creatine may support brain function and cognitive function and mental fatigue,” says Mary Opfer, RD, a clinical associate professor and director of the Nutrition and Dietetics Teaching Kitchen at Pace University in White Plains, New York. “However, I believe that we need more evidence and data, particularly in the dosing protocol.”

Even in nonathletes, creatine supplements may help improve brain sharpness, especially as people age. Several studies have found that taking creatine supplements reduces mental fatigue and may improve cognition, executive function, and memory.

One review found that participants who took 8 grams of creatine for five days increased oxygen utilization in the brain and reduced mental fatigue when they performed repetitive mathematical calculations. It also found memory and processing speed increased with 5 grams of creatine taken for six weeks, and that long-term memory tasks were significantly improved in older adults who took creatine supplements.

6. It May Help Improve Diabetes Management

Creatine supplementation may also help people with type 2 diabetes better manage blood sugar levels. The muscle enzyme CKMT2 — which helps to manage how muscles use creatine — is lower in those with type 2 diabetes — which appears to be a result of insulin resistance.

“A combination of regular exercise, either aerobic or resistance training, with creatine supplementation could have a noticeable effect on blood sugar levels,” says Opfer. “Creatine can be used as a complementary strategy when working out to improve glucose uptake.”

Other research on 87 study participants with type 2 diabetes found that creatine supplementation was as effective as the prescription treatment metformin for lowering glycemic levels. However, the researchers note that larger, more extensive research needs to be done before these initial findings can be verified.

 If you have diabetes, continue to take the medications that your doctor prescribes for you and discuss whether any supplements may benefit your health.

7. It May Help Heart Health

The heart is a muscle that may benefit from creatine too. The energy it needs to pump blood comes from a molecule known as adenosine triphosphate (ATP), and creatine can help transport ATP, thereby helping to ensure that the heart has enough of it to function properly.

Although this area of research isn’t as talked about as athletic performance, “It may play a big role in those at risk of heart disease,” says Balls. “More robust, double-blind, and randomized clinical human trials are needed on this topic to make conclusions.”

Creatine may also help those who currently have serious heart issues. Research suggests that creatine supplementation may improve some cardiac function in heart failure patients because it improves the endurance and strength of muscles in the body, helping to improve overall health and quality of life.

Creatine may also help lower triglycerides, a type of fat found in the blood that, at high levels, may increase the risk of heart disease.

A small study of adults in their late fifties found that four weeks of creatine supplements led to a significant improvement in triglyceride levels.

The Takeaway

  • Creatine is a natural compound that helps transport energy throughout your body. Creatine supplementation may enhance physical performance, muscle size, and strength, and it may also increase endurance and help speed post-exercise recovery.
  • Beyond athletic performance, creatine supplementation may help manage blood sugar levels in those with type 2 diabetes, reduce symptoms of depression, and promote heart health.
  • More research is needed to bolster many of the health claims about creatine, so speak to your healthcare provider before trying these supplements.

Sold on creatine? Read up on the best options out there with our list of the best creatine supplements to boost your workouts.

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
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Kara-Andrew-bio

Kara Andrew, RDN, LDN

Medical Reviewer

Kara Andrew, RDN, LDN, is the director of health promotion for Memorial Hospital in Carthage, Illinois. She is also licensed as an exercise physiologist and certified in lifestyle medicine by the American College of Lifestyle Medicine. Her experience includes corporate wellness, teaching for the American College of Sports Medicine, sports nutrition, weight management, integrative medicine, oncology support, and dialysis.

She earned her master's in exercise and nutrition science at Lipscomb University.

Andrew has served as a president and board member of the Nashville Academy of Nutrition and Dietetics. She was recently elected a co-chair of the fitness and medicine group in the American College of Lifestyle Medicine.

Kelsey Kloss

Author

Kelsey Kloss is a health and wellness journalist with over a decade of experience. She started her career as an in-house editor for brands including Reader’s Digest, Elle Decor, Good Housekeeping, Prevention, Woman's Day, and Redbook, and her work has been featured in over 50 publications.