Caffeine Sensitivity 101: Risk Factors, Symptoms, and Energizing Alternatives

Caffeine Sensitivity 101: Risk Factors, Symptoms, and Energizing Alternatives

Caffeine Sensitivity 101: Risk Factors, Symptoms, and Energizing Alternatives
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Have you ever noticed that some people can fall fast asleep immediately after downing a double shot of espresso, while others have a single cup of coffee and feel wide-eyed well into the night? Turns out, there are varying levels of sensitivity to caffeine, which means the way coffee affects two people may be vastly different.

Caffeine acts as a stimulant in the central nervous system, which leads to feeling more awake and alert.

In the average adult, caffeine has a half-life — meaning how long something remains active in the body — of about 5 hours.
But here’s how caffeine sensitivity can come into play: Various factors can impact the duration of that half-life. For example, it may be shorter in smokers but longer in pregnant people.

6 Reasons You're Sensitive to Caffeine

Discover 6 common factors that may make you more sensitive to caffeine.
6 Reasons You're Sensitive to Caffeine

Here, learn more about caffeine sensitivity and common causes and risk factors. Then, get the tea on energizing alternatives.

What Is Caffeine Sensitivity, and What Are the Symptoms?

When someone has caffeine sensitivity, they feel the effects of caffeine much more strongly than those without a sensitivity. The person may feel as though they have had several shots of espresso after just a few sips of coffee.

According to Mayo Clinic, most people can easily tolerate a daily dose of up to 400 milligrams (mg) of caffeine, which is the amount in about four cups of coffee, without any negative side effects.

People with caffeine hypersensitivity cannot tolerate even the smallest amount of caffeine without experiencing negative side effects, like not being able to sleep.

“Insomnia when consuming caffeine can be an indication that caffeine has impacted your sleep cycle,” says Erin Palinski-Wade, RD, CDCES, a New Jersey–based dietitian and author of 2-Day Diabetes Diet. “If you experience a racing heartbeat or palpitations, consult your physician to determine what, if any, amount of caffeine is safe for you to consume.”

Some additional symptoms of caffeine sensitivity or intolerance include:

  • Headache
  • Jitters
  • Insomnia
  • Restlessness
  • Anxiety
  • Racing heartbeat
If any of this sounds familiar and you consume caffeine regularly, try tracking your intake, and be sure to read food labels to spot hidden sources of caffeine (hello, chocolate!).

It’s also a good idea to voice your concerns to a doctor in case there may be another cause of your symptoms.

What Causes Caffeine Sensitivity?

A number of factors can contribute to caffeine sensitivity. Some of them you can’t control. Here are some of the most common risk factors for caffeine sensitivity:

You Take the Birth Control Pill

If you take a birth control pill, know that caffeine competes for the same enzymes in the liver that also process estrogen. When synthetic hormones are introduced in the body, as is the case with oral contraceptives, the body may process caffeine at about one-third the speed it would otherwise, according to one small study.

You Take Certain Medications and Supplements

Some types of medications and supplements may interact with caffeine, making its side effects more pronounced. For example, bronchodilators, which are used to treat respiratory issues, and echinacea, an herbal supplement, can both increase the effects of caffeine in the body.

Check with your doctor or pharmacist to see whether any of your meds or supplements may be affecting how your body processes caffeine.

It’s in Your Genes

There’s a genetic component to how the body processes caffeine, meaning that your genes alone can make you hypersensitive to it. Specifically, research points to variations in the ADORA2A and CYP1A2 genes correlating to caffeine’s varied effect on people.

You Don’t Usually Consume Caffeine

Caffeine has a stronger effect on those who don’t consume it regularly compared with those who have built up a tolerance. Think of it this way: The more “practice” your body has at metabolizing caffeine, the more efficient it seems to be at it. According to Mayo Clinic, simply not consuming caffeine regularly can lead to a higher sensitivity to it.

You Have Baseline Anxiety

If you already have anxiety or high levels of stress, caffeine can worsen the symptoms you’re already experiencing.

For example, one systematic review of 10 studies found that caffeine increased anxiety and risk of panic attacks in those with panic disorders, with about 51 percent of the 237 participants having a panic attack after consuming caffeine, compared with zero who had a placebo.

Energizing Drinks That Don’t Contain Caffeine

If you self-identify as being sensitive to caffeine but still crave the jolt of energy it can supply, there’s good news and bad news.

The bad news is your best bet is to cut back on caffeine and work toward abstaining from it. “If people are sensitive to caffeine, I recommend they avoid caffeinated beverages completely,” recommends Lynn Grieger, RDN, CDCES, a health, food, and fitness coach in private practice in Chromo, Colorado, and a medical reviewer for Everyday Health. “Reduce caffeine gradually to avoid fatigue and side effects such as headaches. Aim to cut your caffeine intake by 25 percent every two to three days until you can keep it below 100 mg or less per day.”

Now for the good news: Caffeine alternatives exist. Here are some top options to try:

Decaf Coffee and Decaf or Caffeine-Free Tea

“Coffee lovers may find that using decaffeinated coffee works well for them, but some of my coffee-loving clients tell me that they have greater success reducing caffeine when they replace coffee with a naturally caffeine-free herbal tea, such as chamomile tea,” says Grieger. Some teas are naturally caffeine-free, while others have the caffeine removed — both are great choices.

Keep in mind that even decaf coffee and decaf tea do contain a small amount of caffeine, so they may not be the perfect choice for those looking to go completely caffeine-free.

Kombucha

With its natural carbonation and lower amount of caffeine than tea, kombucha can make a healthy and energy-boosting choice. It’s also a great lower-sugar alternative to many sodas.

Wheatgrass

Wheatgrass is a source of essential vitamins and minerals. A shot of it may help give you a little extra burst of energy without any caffeine.

Mushroom Coffee Alternative

If you’re looking for a warm beverage that mimics the earthy flavor of coffee without the jitters you may get from a caffeine sensitivity, try mushroom coffee.

Experience the perfect alternative to traditional coffee with the best mushroom coffee that offers sustained energy without the jitters, ideal for those with caffeine sensitivity. Discover the benefits of mushroom coffee today!

Chicory Herbal Coffee Substitute

Made from natural ingredients, such as chicory and herbs (there’s even a variety that contains dandelion), an herbal coffee substitute, like options from Teeccino, may be the perfect warm and flavorful replacement for your daily coffee.

Golden Milk Latte Mix

With turmeric, dates, cardamom, and vanilla as its main ingredients, a golden milk herbal mix can be easily frothed into a warming latte.

Other Research-Backed Strategies to Help Boost Your Energy Naturally

Foods and beverages aren’t the only strategies for improving your energy levels. A host of lifestyle habits may help and are, of course, caffeine-free.

Get Moving

While it may seem counterintuitive to expend energy to gain more, the truth is that exercise is adept at doing just that.

According to Harvard Health, exercise increases energy supply through promoting better sleep, oxygen circulation, and mitochondria reproduction in the cells.

Aim for at least 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity activity each week, per the recommendations for adults outlined in the Physical Activity Guidelines for Americans.

Get Enough Sleep

Perhaps the most common reason you might find yourself running to the coffee shop is not getting enough sleep the night before. For optimal health, the National Heart, Lung, and Blood Institute recommends adults get 7 to 9 hours of sleep each night.

Practice Yoga and Mindful Meditation

Slowing down and breathing deeply can not only make you feel calmer but can also increase energy. According to research, mindfulness meditation can improve mood and focus.

Cut Back on Screen Time

Living with your phone in your hand can drain your energy. According to research, blue light exposure before bed (from sources like cellphones and television) decreases sleep quality and duration.

Before bed, skip the Netflix marathon or Instagram scrolling in lieu of reading a book (on paper, not a tablet) or doing some deep-breathing exercises for a better night’s sleep.

Get Some Sunshine

Vitamin D is known as the “sunshine vitamin” for a reason. When the sun’s rays hit our skin, it tells our bodies to make more vitamin D. And this process can do wonders for our energy and mood. Vitamin D deficiency has associations with a host of symptoms, including muscle fatigue and mood changes.

To get your fix, some research and experts recommend standing in the sun without sunscreen for 5 to 30 minutes at least twice per week between 10 a.m. and 4 p.m.

Direct sunlight is key; your body won’t synthesize vitamin D if you’re being exposed through a screen or window, for instance. And know that living in certain latitudes and having darker skin may also affect how much vitamin D you’ll make.

Have a Healthy Breakfast

Breakfast can set the tone for your whole day, energetically speaking. A protein-rich breakfast that also contains whole grains is a perfect balance of energy-boosting nutrition.

For example, eggs with whole-grain toast, yogurt with whole-grain cereal, or steel-cut oatmeal with nuts are all nutritionally balanced and filling choices. Whole-grain carbohydrates and protein work together to slow digestion, which supports sustained energy.

Drink More Water

Research has found that even mild dehydration can significantly affect energy, mood, and brainpower because it decreases the volume of blood in the body and, therefore, the amount of blood reaching the brain.

“I encourage all of my clients to make plain, unflavored water their primary beverage,” says Grieger.

Get Enough Vitamin B12

Most Americans get plenty of vitamin B12 to meet their needs because it’s found in high amounts in foods such as dairy products, fortified breakfast cereals, trout, salmon, tuna, clams, and beef. But vegetarians and vegans, those with digestive issues, and those over age 50 are more likely to become deficient in vitamin B12.

Vitamin B12 helps your body break down food into glucose, which the brain uses for energy. So, vitamin B12 deficiency can zap energy levels. Getting it from a supplement can increase energy and endurance.

The Takeaway

  • Caffeine is a stimulant that can affect people differently. Some people are more sensitive to caffeine than others, feeling its effects more strongly.
  • Common causes of caffeine sensitivity include having a genetic predisposition, not regularly consuming caffeine, taking certain medications, and more.
  • If you believe you are sensitive to caffeine, work to cut back on your consumption by opting for decaf or caffeine-free alternatives and incorporating energizing lifestyle habits into your routine.
EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Evans J et al. Caffeine. StatPearls. May 29, 2024.
  2. Caffeine: How much is too much? Mayo Clinic. February 21, 2025.
  3. Caffeine Sensitivity. Cleveland Clinic. December 1, 2025.
  4. Adachi K et al. Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman. Acute Medicine & Surgery. August 12, 2024.
  5. Kapellou A et al. Genetics of caffeine and brain-related outcomes - a systematic review of observational studies and randomized trials. Nutrition Reviews. November 10, 2023.
  6. Klevebrant L et al. Effects of caffeine on anxiety and panic attacks in patients with panic disorder: A systematic review and meta-analysis. General Hospital Psychiatry. February 2022.
  7. Golen T et al. Does exercise really boost energy levels? Harvard Health. July 1, 2021.
  8. Physical Activity Guidelines for Americans, 2nd Edition. Department of Health and Human Services. 2018.
  9. How Much Sleep Is Enough? National Heart, Lung, and Blood Institute. March 24, 2022.
  10. Pascoe M et al. Psychobiological mechanisms underlying the mood benefits of meditation: A narrative review. Comprehensive Psychoneuroendocrinology. May 2021.
  11. Silvani MI et al. The influence of blue light on sleep, performance and wellbeing in young adults: A systematic review. Frontiers in Physiology. August 16, 2022.
  12. Vitamin D Deficiency. Cleveland Clinic. August 2, 2022.
  13. Vitamin D: Fact Sheet for Health Professionals. National Institutes of Health Office of Dietary Supplements. June 27, 2025.
  14. Arshad MT et al. Role of Dietary Carbohydrates in Cognitive Function: A Review. Food Science & Nutrition. July 1, 2025.
  15. Dehydration. Cleveland Clinic. June 5, 2023.
  16. Vitamin B12: Fact Sheet for Consumers. National Institutes of Health Office of Dietary Supplements. December 15, 2023.
Kara-Andrew-bio

Kara Andrew, RDN, LDN

Medical Reviewer

Kara Andrew, RDN, LDN, is the director of health promotion for Memorial Hospital in Carthage, Illinois. She is also licensed as an exercise physiologist and certified in lifestyle medicine by the American College of Lifestyle Medicine. Her experience includes corporate wellness, teaching for the American College of Sports Medicine, sports nutrition, weight management, integrative medicine, oncology support, and dialysis.

She earned her master's in exercise and nutrition science at Lipscomb University.

Andrew has served as a president and board member of the Nashville Academy of Nutrition and Dietetics. She was recently elected a co-chair of the fitness and medicine group in the American College of Lifestyle Medicine.

Kelly Kennedy, RDN, LDN

Author

Kelly Kennedy is a licensed dietitian-nutritionist with over 14 years of experience in digital media. She previously managed and oversaw nutrition content, recipe development, meal planning, and diet and nutrition coaching at Everyday Health. She developed and reviewed various meal plans, books, slideshows, and online tools, and oversaw the creation of more than 500 unique recipes. She received her bachelor's degree from the University of Massachusetts, Amherst, and a master's degree from the State University of New York College at Oneonta.

Kennedy enjoys anything that takes her outside, from gardening and playing in the yard with her kids to hiking and even feeding her pet chickens.