Why Blood Sugar Is Harder to Control During Illness, Injury, or Recovery

“When you’re sick or injured, your body temporarily prioritizes survival over perfect glucose control, even if you normally have very stable numbers,” says Scott Isaacs, MD, an Atlanta-based endocrinologist and immediate past president of the American Association of Clinical Endocrinology. “You can be doing everything right and still see your blood sugar spike during an illness. It’s not due to lack of discipline.”
Fortunately, understanding why blood sugar levels can become harder to manage during these situations can help you make a plan to respond more effectively.
The Body’s Stress Response and Blood Sugar
“Illness or injury can set off the body’s natural stress hormone response that’s meant to keep you alive, fight infection, and promote healing. And one part of that response is raising blood sugar,” says Dr. Isaacs.
But in people with diabetes (diagnosed or not), this stress response can overshoot and lead to potentially dangerous elevated blood sugar levels.
It can also complicate day-to-day management for people who are already conscious about managing blood sugar, says Lisal J. Folsom, MD, an endocrinologist and the medical director of the adult endocrinology division of the Wendy Novak Diabetes Institute in Louisville, Kentucky. “The problem arises in insulin resistance, where the body either doesn’t make insulin or can’t make enough insulin to meet the increased demand,” she says. “This can result in persistently high blood sugars, which actually impede the healing response.”
How Illness, Injury, and Recovery Affect Glucose Control
Managing blood sugar is a delicate balance, even when you’re healthy and feeling great, says Dr. Folsom.
Lifestyle factors, such as diet, exercise, and sleep, can add another layer to this challenge:
- Diet is one of the most important tools for managing blood sugar, but your food intake may shift when you’re sick. “With illness, you may have fever, nausea, vomiting, diarrhea, or decreased appetite,” says Folsom. “This can result in dehydration, decreased nutrition intake, and less fuel available for the body to make energy to fight off the illness and recover.”
- Exercise is a main component of blood sugar management, as physical activity typically helps lower blood sugar levels and improves insulin sensitivity. But you may not feel up to exercising — or may not even be able to move — while sick or recovering from an injury or surgery.
- Sleep is also critical for regulating blood sugar levels, and experts generally recommend getting at least seven hours per night to support metabolic health. But symptoms ranging from discomfort and pain to coughing and congestion can easily disrupt rest.
Practical Strategies to Stabilize Blood Sugar During Recovery
- Monitor your levels. “Checking blood sugar more frequently or using a continuous glucose monitor gives you an opportunity to respond before blood sugar goes too high or too low,” says Isaacs.
- Adjust meals accordingly. Pay close attention to meal timing and portion sizes to help lessen large swings, especially if your appetite is off, Isaacs says.
- Consult your care team. Making a plan with your provider “will empower you to manage blood sugar and diabetes at home if symptoms develop at a time you’re not able to immediately contact them,” says Folsom.
- Incorporate gentle movement. “Even brief, gentle physical activity — like short walks around the house or light stretching — can improve insulin sensitivity and help you feel better, as long as it’s safe in the context of your illness or injury,” says Isaacs.
- Drink plenty of water. “Stay hydrated by frequently sipping water or sugar-free liquids if blood sugars are high or liquids that contain some carbs, like juice, if blood sugars are dropping,” says Folsom.
- Prioritize rest. Aim to get as much sleep as you can to support the healing process and stabilize blood sugar.
- Keep an eye on vital signs. Dropping weight without trying can be a sign of high blood sugar, so ask your doctor if you should consider weighing yourself regularly while you recover. Also, be sure to check your temperature every morning and evening, as fever can be a sign of infection, which can also interfere with blood sugar.
- Prepare ahead of time. Plan to keep enough insulin on hand, as well as any other diabetes medications you take. Stock up on a few weeks of easy-to-prepare foods, so you’re not scrambling during recovery.
Most important, Isaacs says, “If you’re seeing unexpected high or low glucose levels, you can’t keep fluids down, or you’re unsure of how to adjust insulin or other medications, contact your physician.”
The Takeaway
- When you get sick, undergo surgery, or injure yourself, blood sugar levels may become more challenging to manage.
- The body’s natural immune response triggers elevated glucose levels during periods of stress and illness to support survival and recovery.
- During these periods, taking steps to monitor glucose levels, make meal and other lifestyle adjustments, and prioritize self-care can help regulate blood sugar and promote healing.
- Your Immune System and Diabetes. Centers for Disease Control and Prevention. May 15, 2024.
- Sharma K et al. Stress-Induced Diabetes: A Review. Cureus. September 13, 2022.
- Blood Glucose & Stress in Diabetes. University of California in San Francisco.
- Lee H et al. Impact of Hyperglycemia on Immune Cell Function: A Comprehensive Review. Diabetology International. October 2024.
- Jain AB et al. Medication-Induced Hyperglycemia and Diabetes Mellitus: A Review of Current Literature and Practical Management Strategies. Diabetes Therapy. September 2024.
- Dhaliwal SD. Managing Your Blood Sugar. MedlinePlus. February 28, 2024.
- Exercise and Glucose Levels in Diabetes. American Diabetes Association.
- Henson J et al. Waking Up to the Importance of Sleep in Type 2 Diabetes Management: A Narrative Review. Diabetes Care. March 2024.
- Nash A. How to Sleep With Chronic Pain: Key Insights and Actionable Tips to Get Relief. Stanford Medicine Pain News. August 5, 2024.
- Managing Sick Days. Centers for Disease Control and Prevention. May 15, 2024.

Anna L. Goldman, MD
Medical Reviewer
Anna L. Goldman, MD, is a board-certified endocrinologist. She teaches first year medical students at Harvard Medical School and practices general endocrinology in Boston.
Dr. Goldman attended college at Wesleyan University and then completed her residency at Icahn School of Medicine at Mount Sinai Hospital in New York City, where she was also a chief resident. She moved to Boston to do her fellowship in endocrinology at Brigham and Women's Hospital. She joined the faculty after graduation and served as the associate program director for the fellowship program for a number of years.

Cristina Mutchler
Author
Cristina Mutchler is an award-winning journalist with more than a decade of experience covering health and wellness content for national outlets. She previous worked at CNN, Newsy, and the American Academy of Dermatology. A multilingual Latina and published bilingual author, Cristina has a master's degree in Journalism from the E.W. Scripps School of Journalism at Ohio University.