Colorectal Cancer Screening: Which Method Is Right for You?
Updated on June 16, 2026
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Colorectal cancer is the second leading cause of cancer death in the United States. However, experts say many of those deaths could be prevented.
Colorectal cancer is one of the cancers for which effective screening exists. For one thing, colorectal cancer nearly always develops from precancerous polyps in the colon or rectum, and doctors can identify them with screening tests and remove them before they turn into cancer.
Additionally, colorectal screening helps doctors spot cancer early, when treatments are most successful. When colorectal cancer is caught early, the five-year survival rate is around 90 percent.
Colonoscopy, in which a camera is threaded through the colon, has always been considered the gold standard screening tool for colorectal cancer, because doctors can literally see inside the colon to look for abnormalities.
But, for a variety of reasons, not everyone is willing or able to undergo this procedure. Sometimes, the colonoscopy prep, which requires a liquid diet prior to the test, as well as medication to clear out the colon, intimidates people, or takes too much time. Sometimes, people are afraid of the test itself and are not willing to undergo it.
The U.S. Preventive Services Task Force (USPSTF), which offers colorectal screening guidelines, recommends that all adults between ages 45 and 75 be screened for colorectal cancer. Decisions for screening adults ages 76 and older should be made on an individual basis, according to the USPSTF.
While colonoscopy is truly considered the gold standard, it’s important to know that if you’re not able or willing to undergo a colonoscopy, there are other options for colorectal cancer screening.
What Are the Types of Screening for Colorectal Cancer?
Colorectal screening tests are divided into three main categories:
- Visual Exams Colonoscopy, sigmoidoscopy, and virtual colonoscopy all involve using scopes to see inside the colon.
- Stool-Based Tests With these, doctors analyze feces for signs of colorectal cancer or polyps.
- Blood Tests These can detect cancerous or precancerous DNA in a blood sample.
All approaches have pluses and minuses. The most important thing is to get screened. “Screening tests only provide benefit if they are completed,” says Douglas A. Corley, MD, PhD, a research scientist at the Kaiser Permanente Northern California Division of Research in Oakland, California. “The best test is the one that gets it done.”
Here are some of the factors you and your doctor will discuss when deciding on a screening strategy:
- Preferences Do you have reservations about being under anesthesia? Do you have the time and transportation necessary to prep and undergo colonoscopy?
- Family or Personal History If you have a family history of colorectal cancer or polyps, your doctor may lean toward recommending a colonoscopy.
- Other Medical Conditions Some conditions may necessitate that you undergo less intensive screening.
- Genetic Syndromes Some genetic syndromes, such as Lynch syndrome, can put you at higher risk of colorectal cancer. Genetic syndromes may mean that a colonoscopy is the best screening method for you.
- Medical Resources Doctors can work with what your insurance will cover.
Poll
What screening test found signs of your colorectal cancer?
Colonoscopy: The Screening Gold Standard
A colonoscopy lets doctors see inside the large intestine, which includes the rectum and colon. Physicians insert a lighted tube with an attached camera into the rectum to view parts of the digestive system. One benefit of the procedure is that it allows the doctors to identify any problems and remove precancerous polyps at the same time.
The American Cancer Society recommends a colonoscopy every 10 years for people with an average risk of colorectal cancer. You may need to undergo screening at a younger age and more often if you have more risk factors, such as a family history or a genetic mutation that puts you at higher risk.
It’s estimated that colonoscopies reduce the risk of colorectal cancer by approximately 40 to 69 percent, and reduce colorectal cancer deaths by 29 to 88 percent.
Flexible Sigmoidoscopy
A flexible sigmoidoscopy is a procedure that’s similar to a colonoscopy, but it doesn’t examine the entire colon. With this exam, a flexible tool that contains a light and a camera is inserted into the rectum and moved through the lower part of the colon. Doctors can view the entire rectum during a sigmoidoscopy — but less than half of the colon.
Because a flexible sigmoidoscopy doesn’t let doctors see the entire colon, it’s possible that it won’t detect cancer or polyps farther into the colon. Because of this, sigmoidoscopies aren’t commonly used.
That said, a flexible sigmoidoscopy can be a good screening test when done every five years — or every 10 years if it’s combined with an annual fecal test.
Virtual Colonoscopy (CT Colonography)
A virtual colonoscopy is an exam in which you follow the prep used to clean out the colon for a regular colonoscopy, but the exam is not invasive. Instead of using a scope to examine the inside of the colon, doctors use X-rays and computed tomography (CT) scans to generate images of the colon.
When it’s performed correctly, a virtual colonoscopy can be as effective as a traditional colonoscopy at detecting cancer and most polyps. The Centers for Disease Control and Prevention says that this test should be performed every five years as a screening tool for colorectal cancer.
Stool Tests
Stool tests are used to detect abnormalities in feces.
There are different types of stool tests, including:
- Fecal Immunochemical Test (FIT) FIT uses antibodies to detect blood in the stool. It’s performed once a year as a screening tool.
- FIT-DNA Test This test combines FIT with a technology that detects abnormal DNA in the stool. It’s done once every three years.
- Guaiac-Based Fecal Occult Blood Test (gFOBT) With this test, the chemical guaiac detects blood in the stool. Experts recommend that it should be done once a year.
- Multitargeted Stool RNA (mt-sRNA) Test A test like this, such as Colosense, looks for changes in RNA that could be due to cancer or polyps, as well as for blood in the stool. It’s recommended every three years.
- Multitargeted Stool DNA (mt-sDNA) Test This looks for potentially cancerous changes in DNA or blood in the stool. It’s also recommended every three years. An example of this test is Cologuard.
“These [stool] tests are thought to have similar effectiveness in decreasing deaths from colorectal cancer, when used as recommended,” Dr. Corley says. Most medical centers offer both colonoscopies and stool tests, to achieve the highest screening rates, he says. If an abnormality is detected in a stool test, it will often be followed up with a colonoscopy.
Blood Test
A blood-based test is used to check for signs of colorectal cancer in your blood. A blood sample is taken at a doctor’s office, then sent to a lab, where it will be analyzed for DNA changes that indicate cancerous or precancerous cells. Currently, there’s one blood test — Shield — that’s approved by the U.S. Food and Drug Administration as a primary screening test for colorectal cancer.
Shield is recommended at least once every three years, although it’s not yet clear how often the blood test should be repeated. However, this blood test is not the preferred screening option, as it’s not as good at finding precancerous growths. As with the other screening tests, you’ll need to follow up with a colonoscopy if your results are positive.
Resources We Trust
- Mayo Clinic: Colon Cancer
- Cleveland Clinic: Colonoscopy
- American Cancer Society: Colorectal Cancer Screening Tests
- National Cancer Institute: Colorectal Cancer Prevention (PDQ)-Patient Version
- U.S. Preventative Services Task Force: Colorectal Cancer: Screening
EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
- Cancer Stat Facts: Colorectal Cancer. National Cancer Institute.
- Screening for Colorectal Cancer. Centers for Disease Control and Prevention. February 26, 2025.
- Colorectal Cancer Screening (PDQ)-Health Professional Version. National Cancer Institute. April 10, 2025.
- Colorectal Cancer: Screening. U.S. Preventive Services Task Force. May 18, 2021.
- American Cancer Society Guideline for Colorectal Cancer Screening. American Cancer Society. May 27, 2026.
- Colorectal Cancer Screening Tests. American Cancer Society. May 27, 2026.
- Don’t Give Up on Screening Colonoscopy. Cleveland Clinic. January 10, 2023.
- Flexible Sigmoidoscopy. Mayo Clinic. July 9, 2024.
- Virtual Colonoscopy. Mayo Clinic. July 9, 2025.
- Guardant Health’s Shield Blood Test Approved by FDA as a Primary Screening Option, Clearing Path for Medicare Reimbursement and a New Era of Colorectal Cancer Screening. Guardant. July 29, 2024.
- Screening for Colorectal Cancer. CA: A Cancer Journal for Clinicians. May 27, 2026.
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