How to Maximize Quality of Life With Advanced Renal Cell Carcinoma

There are things you can do, however, to regain energy and stamina and start feeling better — and some of them require only 15 minutes (or less). Here are five changes to make today to improve your quality of life.
1. Take a 15-Minute Walk Outside
The idea of working out may sound mentally and emotionally overwhelming, says Jacqueline T. Brown, MD, a medical oncologist with Emory Healthcare and an assistant professor at the Winship Cancer Institute of Emory University in Atlanta, but just a 15-minute walk can ease fatigue.
2. Treat Side Effects
Advanced cancer treatments like immunotherapy and targeted therapies can cause side effects that can interfere with your daily life. “With close follow-up and dose alterations, though, these can usually be well managed,” says Anthony Gulati, MD, a hematologist-oncologist with Stamford Health in Stamford, Connecticut.
- Fatigue
- Nausea and vomiting
- Diarrhea or constipation
- Irritation of the skin on your hands and feet
- High blood pressure
- Poor appetite
- Joint pain
“It is important to keep an open dialogue with your physician so that they can be active in managing these or any side effects that come up during treatment,” says Gulati.
3. ‘Over-Communicate’ With Your Care Team
Some of Brown’s patients are hesitant to “bother” their doctors. “But,” says Brown, “big treatment side effects can start with small symptoms, so I tell them, ‘Please let me help you decide if something is important — don’t decide on your own that it isn’t.’”
If you’re not sure how to reach your care team with questions, ask your provider at your next appointment how you can best communicate with them.
4. Find Your Treatment ‘North Star’
“I encourage my patients to define their ‘why’ for seeking treatment,” says Brown. “I try to keep this reason as our metaphorical North Star throughout their treatment course.”
For example, some people may choose a more aggressive form of treatment, despite the side effects, whereas others want to live life to the fullest, without experiencing more side effects. When you can keep your North Star at the forefront, this can help you enjoy your life more, says Brown.
5. Ask About Palliative Care
- External beam radiation therapy: Targets an area of cancer with beams of radiation, relieving some cancer symptoms
- Arterial embolization: A surgical procedure that blocks blood from reaching a tumor
- Mental health support: To help you work through feelings about your cancer diagnosis and treatment
- Financial and legal guidance: Managing financial planning, insurance, and legal forms like advanced directives
- Clinical trials: Joining a study of new treatments to improve quality of life
The Takeaway
- Advanced renal cell carcinoma can bring challenges, but you can maximize your quality of life with a few small lifestyle changes.
- Try to take a short walk every day, talk to your care team about new or worsening side effects, and ask about palliative care.
- Advanced renal cell carcinoma and its treatment can cause uncomfortable symptoms and side effects, but your care team can help adjust your treatment regimen to keep you as comfortable as possible.
Resources We Trust
- Mayo Clinic: Renal Cell Carcinoma: Understanding Exactly What a Kidney Cancer Diagnosis Means
- Cleveland Clinic: Kidney Cancer
- Action Kidney Cancer: Health-Related Quality of Life Questionnaires for Patients With Kidney Cancer
- Kidney Cancer Association: What Palliative Care Is and Isn't
- CancerCare: Kidney Cancer
- Kotronoulas G et al. Wellbeing Status and Priority Concerns of Patients With Advanced Renal Cell Carcinoma: Results of the EONS PRMOS Project International Online Survey. Supportive Care in Cancer. June 3, 2025.
- Gross F et al. Health-Related Quality of Life Assessment in Renal Cell Cancer: A Scoping Review. European Urology Oncology. February 2025.
- Kidney Cancer. National Kidney Foundation. September 19, 2025.
- Side Effects of Cancer Treatment. National Cancer Institute.
- Drozd C et al. Exercise Intervention on Insomnia in Patients with a Cancer: A Systematic Review of the Literature. Cancers. June 17, 2024.
- de Menezes-Júnior LAA et al. The Role of Sunlight in Sleep Regulation: Analysis of Morning, Evening and Late Exposure. BMC Public Health. October 6, 2025.
- Immunotherapy for Kidney Cancer. American Cancer Society. May 1, 2024.
- Targeted Drug Therapy for Kidney Cancer. American Cancer Society. May 1, 2024.
- Nausea and Vomiting and Cancer Treatment. National Cancer Institute. May 9, 2025.
- Diarrhea and Cancer Treatment. National Cancer Institute. May 16, 2025.
- Hand-Foot Syndrome. American Cancer Society. June 12, 2025.
- Communication in Cancer Care (PDQ®)–Health Professional Version. National Cancer Institute. May 12, 2025.
- Renal Cell Cancer Treatment (PDQ®)–Patient Version. National Cancer Institute. May 12, 2025.
- Palliative Care. American Cancer Society. August 15, 2025.
- Wadiwala J et al. Health Care Disparities and Barriers to Palliative Care Among Metastatic Renal Cell Carcinoma Patients: An NCDB Analysis. Journal of Clinical Oncology. May 28, 2021.

Daniel Landau, MD
Medical Reviewer
Daniel Landau, MD, is a distinguished board-certified hematologist-oncologist with a career that has spanned two eminent institutions: the Orlando Health Cancer Institute and the M...

Abby McCoy, RN
Author
Abby McCoy is an experienced registered nurse who has worked with adults and pediatric patients encompassing trauma, orthopedics, home care, transplant, and case management. She is...