Ways to Maximize Quality of Life With Advanced Renal Cell Carcinoma

How to Maximize Quality of Life With Advanced Renal Cell Carcinoma

How to Maximize Quality of Life With Advanced Renal Cell Carcinoma
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When you have advanced renal cell carcinoma (RCC), both the cancer and its treatments can cause symptoms such as pain, low energy, and poor sleep — all of which can take a toll on your quality of life and make it harder to go about your day.

There are things you can do, however, to regain energy and stamina and start feeling better — and some of them require only 15 minutes (or less). Here are five changes to make today to improve your quality of life.

1. Take a 15-Minute Walk Outside

Renal cell carcinoma and its treatment can cause fatigue and trouble sleeping, but exercise can help you regain some of your energy.

For example, research has shown that 6 to 10 weeks of regular exercise can help ease symptoms of insomnia among people with cancer.

The idea of working out may sound mentally and emotionally overwhelming, says Jacqueline T. Brown, MD, a medical oncologist with Emory Healthcare and an assistant professor at the Winship Cancer Institute of Emory University in Atlanta, but just a 15-minute walk can ease fatigue.

If you can exercise outdoors in the sun, that’s even better, since sunlight has been shown to help you sleep better, says Dr. Brown. (Just don’t forget the sunscreen.)

 “With that said, I trust my patients to know their bodies and know when they need to rest — and that trumps all else,” Brown says.

2. Treat Side Effects

Advanced cancer treatments like immunotherapy and targeted therapies can cause side effects that can interfere with your daily life. “With close follow-up and dose alterations, though, these can usually be well managed,” says Anthony Gulati, MD, a hematologist-oncologist with Stamford Health in Stamford, Connecticut.

Some of these side effects include:

  • Fatigue
  • Nausea and vomiting
  • Diarrhea or constipation
  • Irritation of the skin on your hands and feet
  • High blood pressure
  • Poor appetite
  • Joint pain
For nausea and vomiting, your doctor may prescribe an antiemetic, like ondansetron (Zofran).

 If you have diarrhea or constipation, you may need to adjust your diet or take some additional temporary medications. For severe diarrhea, your doctor may give you IV fluids to prevent dehydration, or either pause your treatment or lower your dose until the symptoms ease.

If you’re taking tyrosine kinase inhibitors (or TKIs, a type of targeted therapy), you may develop a rash called hand-foot syndrome, says Dr. Gulati. If this happens, you can lessen the redness, swelling, and pain with doctor-recommended creams, lotions, pain medications, or skin-cooling socks and gloves.

“It is important to keep an open dialogue with your physician so that they can be active in managing these or any side effects that come up during treatment,” says Gulati.

3. ‘Over-Communicate’ With Your Care Team

Good communication between you and your care team can lay the groundwork for the best possible treatment with the fewest negative effects.

 “I always say, if you don’t tell me about your symptoms, I can’t help, so please tell me,” says Brown.

Some of Brown’s patients are hesitant to “bother” their doctors. “But,” says Brown, “big treatment side effects can start with small symptoms, so I tell them, ‘Please let me help you decide if something is important — don’t decide on your own that it isn’t.’”

If you’re not sure how to reach your care team with questions, ask your provider at your next appointment how you can best communicate with them.

4. Find Your Treatment ‘North Star’

The treatment plans for advanced renal cell carcinoma can change over time — but no matter what you choose to try next, keep your primary goal in mind.

“I encourage my patients to define their ‘why’ for seeking treatment,” says Brown. “I try to keep this reason as our metaphorical North Star throughout their treatment course.”

For example, some people may choose a more aggressive form of treatment, despite the side effects, whereas others want to live life to the fullest, without experiencing more side effects. When you can keep your North Star at the forefront, this can help you enjoy your life more, says Brown.

5. Ask About Palliative Care

Palliative care is simply care that helps you manage your symptoms and improves your quality of life. You can receive palliative care as soon as you get your diagnosis, throughout treatment, and beyond.

Some types of palliative care include:

  • External beam radiation therapy: Targets an area of cancer with beams of radiation, relieving some cancer symptoms
  • Arterial embolization: A surgical procedure that blocks blood from reaching a tumor
  • Mental health support: To help you work through feelings about your cancer diagnosis and treatment
  • Financial and legal guidance: Managing financial planning, insurance, and legal forms like advanced directives
  • Clinical trials: Joining a study of new treatments to improve quality of life
Research shows that both Black and Hispanic patients have a lower chance of receiving palliative care than white patients.

 If you would like palliative care, but your medical center doesn’t offer it, you can search the Get Palliative Care directory for options near you.

The Takeaway

  • Advanced renal cell carcinoma can bring challenges, but you can maximize your quality of life with a few small lifestyle changes.
  • Try to take a short walk every day, talk to your care team about new or worsening side effects, and ask about palliative care.
  • Advanced renal cell carcinoma and its treatment can cause uncomfortable symptoms and side effects, but your care team can help adjust your treatment regimen to keep you as comfortable as possible.

Resources We Trust

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
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  2. Gross F et al. Health-Related Quality of Life Assessment in Renal Cell Cancer: A Scoping Review. European Urology Oncology. February 2025.
  3. Kidney Cancer. National Kidney Foundation. September 19, 2025.
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  5. Drozd C et al. Exercise Intervention on Insomnia in Patients with a Cancer: A Systematic Review of the Literature. Cancers. June 17, 2024.
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  7. Immunotherapy for Kidney Cancer. American Cancer Society. May 1, 2024.
  8. Targeted Drug Therapy for Kidney Cancer. American Cancer Society. May 1, 2024.
  9. Nausea and Vomiting and Cancer Treatment. National Cancer Institute. May 9, 2025.
  10. Diarrhea and Cancer Treatment. National Cancer Institute. May 16, 2025.
  11. Hand-Foot Syndrome. American Cancer Society. June 12, 2025.
  12. Communication in Cancer Care (PDQ®)–Health Professional Version. National Cancer Institute. May 12, 2025.
  13. Renal Cell Cancer Treatment (PDQ®)–Patient Version. National Cancer Institute. May 12, 2025.
  14. Palliative Care. American Cancer Society. August 15, 2025.
  15. Wadiwala J et al. Health Care Disparities and Barriers to Palliative Care Among Metastatic Renal Cell Carcinoma Patients: An NCDB Analysis. Journal of Clinical Oncology. May 28, 2021.

Daniel Landau, MD

Medical Reviewer

Daniel Landau, MD, is a distinguished board-certified hematologist-oncologist with a career that has spanned two eminent institutions: the Orlando Health Cancer Institute and the M...

Abby McCoy, RN

Author

Abby McCoy is an experienced registered nurse who has worked with adults and pediatric patients encompassing trauma, orthopedics, home care, transplant, and case management. She is...