Neutropenic Diet for Metastatic Breast Cancer: Safe and Nutritious Tips and Meal Ideas

Eating With MBC and Neutropenia: Meal Ideas and Food Safety Tips

Eating With MBC and Neutropenia: Meal Ideas and Food Safety Tips
Everyday Health
Metastatic breast cancer (MBC) treatments are known to cause side effects. One major side effect of chemotherapy is neutropenia, which occurs when chemo drugs destroy the germ-fighting white blood cells called neutrophils or block their production in bone marrow. This lowers the level of neutrophils in your blood and leaves your body more vulnerable to infection.

Eating with neutropenia can be stressful because there's always a chance that bacteria and other germs in undercooked or contaminated food could make you sick.

Food safety is essential. "The immune system is weakened, so [you’re] more likely to experience foodborne illnesses," says Katie Roberts, RD, a senior clinical dietitian at MD Anderson Cancer Center in Houston.
On top of that, metastatic breast cancer treatments cause side effects like mouth sores, taste changes, and appetite loss that make it difficult to eat.

A nutritious diet is important for anyone living with MBC. "It improves quality of life and helps people feel their best, keep their energy up, and get good sleep," says Cara Anselmo, RDN, of Memorial Sloan Kettering Cancer Center in New York City.

These food preparation tips and meal ideas can help you stay nourished and infection-free during your treatment.

Prep and Store Food Safely

Eating a varied diet complete with fruits, vegetables, poultry, seafood, and meat is still possible with MBC and neutropenia. But because the drop in white blood cells weakens the immune system and increases the risk for foodborne illness, take extra precautions when preparing and storing food.

The U.S. Department of Agriculture has created special food safety guidelines for people who are at a higher risk of foodborne infections, including those with cancer. Follow these recommendations for preparing and storing food safely.

Clean Your Hands and Cooking Tools

Wash your hands for at least 20 seconds with warm water and soap before and after handling food. It's especially important to wash them after you go to the bathroom, change a diaper, and touch pets.

Clean all cooking tools, including dishes, utensils, and cutting boards, in warm, soapy water. Sanitize cutting boards and countertops with a mixture of 1 tablespoon of bleach and a gallon of water. Or clean cutting boards in a dishwasher.

Avoid Cross Contamination

Raw meat, poultry, seafood, and eggs can spread bacteria to any other foods they touch. To avoid cross contamination, keep raw and cooked foods separate in the refrigerator and when preparing food.

"Make sure that you have completely separate cutting boards for meat and [other] animal products, and for the vegetables," says Anselmo.

Cook Thoroughly

A meat thermometer is an essential tool for anyone with MBC and neutropenia, as heat kills germs. Temperature recommendations are different for each type of food.

Food
Recommended minimum cooking temperature
Ground beef
160 degrees F
Ground chicken, turkey, and other poultry
165 degrees F
Seafood
145 degrees F or until the shells turn red (shrimp, lobster, and crab) or open up (clams, mussels, and oysters)
Eggs
160 degrees F or until the yolks and whites are firm
Beef, lamb, pork, and veal
145 degrees F; let rest 3 minutes after removing from the heat
Hot dogs and deli meat (such as ham and bologna)
165 degrees F
Most reheated leftovers and sauces
165 degrees F or until boiling

Refrigerate or Freeze

Keeping food at the right temperature prevents bacteria from growing. Store meat, poultry, eggs, and seafood in the refrigerator or freezer within two hours after buying or cooking.

Don't leave any food — even if it's fully cooked — on the counter for more than two hours, one hour if the temperature is over 90 degrees F. Leftovers should go straight into the fridge or freezer, too. Reheat and eat them within two days of cooking.

Watch for improperly stored foods when eating out, too. "Avoid things like salad bars and buffets where the food is sitting out, because you don't know who's touched it, if it's been kept at the right temperature, and how long it's been sitting there," says Anselmo.

Choose Raw Foods Wisely

Some raw foods are safer than others if you have MBC and neutropenia. Produce is fine, as long as it's cleaned. "Make sure you wash fresh produce thoroughly under water before cutting into it and preparing it," Roberts says. Even wash fruits and vegetables that have a peel, such as bananas and avocados, because bacteria on the outside could get inside the fruit when you cut it open.

Avoid eating these foods raw or undercooked:

  • Eggs
  • Sushi, smoked salmon, and other fish and shellfish
  • Meat
  • Sprouts such as alfalfa, bean, and broccoli
  • Unpasteurized milk, juice, and honey
  • Cheese made from unpasteurized milk, which often includes soft cheeses like Brie, Camembert, and goat cheese

What Is the Neutropenic Diet?

The neutropenic diet was created for people who have a weakened immune system, such as those who have cancer or have had a stem cell transplant.

 It's a restrictive diet that cuts out any foods that might contain bacteria or other illness-causing germs, such as raw fruits and vegetables; raw and undercooked meat, fish, and eggs; and unpasteurized dairy.

Research has shown that the neutropenic diet doesn't necessarily reduce the risk of infection or improve quality of life in people with cancer. And because it's so restrictive, it could lead to nutrient deficiencies.

Today, the original neutropenic diet is rarely recommended. Sometimes people who've had a stem cell transplant must eat a more restrictive diet because their immune system has been wiped out and needs time to regenerate. But for people with neutropenia from cancer, it's more important to follow basic food safety practices, like avoiding raw or undercooked animal products and washing raw fruits and vegetables, Anselmo says.

Other dietary advice depends on the type of treatment side effects. For example, if you have diarrhea, avoid salads and other raw vegetables, beans, and whole grains. Instead, eat foods that are gentler on the digestive tract, like vegetable soup. If you have mouth sores or irritation, focus more on food temperature and texture. "Maybe it's avoiding things that are super hot or avoiding spicy foods or foods with hard edges like crackers," Anselmo says.

To ensure that you're getting enough nutrition, each meal should contain a mix of protein, healthy fats, and fiber-rich carbohydrates, says Anselmo. Calories and protein are especially important because neutropenia destroys white blood cells. "Your body needs fuel from calories and protein to be able to regenerate those blood cells," Roberts says.

Anselmo and Roberts recommend the following safe and healthy meal ideas for people with MBC and neutropenia.

Breakfast:

  • Banana smoothie
  • Hard-boiled egg on toast with avocado
  • Bowl of oatmeal with a scoop of yogurt topped with fruit

Lunch:

  • Brown rice with beans or lentils
  • Peanut butter and banana on toast
  • Grilled chicken, low-fat cheese, and black beans wrapped in a whole-grain tortilla

Snack:

  • Toast topped with peanut butter and apple slices
  • Greek yogurt with nuts and seeds
  • Cottage cheese with fruit

Dinner:

  • Vegetable soup
  • Grilled chicken kabob

Seeing a Dietitian-Nutritionist

A dietitian can help you plan meals that match your tastes and health needs. Ideally, choose someone who has experience working with people with cancer. "I definitely recommend connecting with a board-certified oncology dietitian — someone who has CSO after their credential. CSO means certified specialist in oncology," says Hillary Sachs, RD, a board-certified specialist in oncology nutrition.

To find a dietitian in your area, ask your oncology team or search the Academy of Nutrition and Dietetics website.

The Takeaway

  • Metastatic breast cancer treatments can cause a low white blood cell count (neutropenia), which increases the risk for foodborne illness.
  • To ensure that your food is safe, clean your hands and cooking tools, and cook foods to the recommended temperature before eating them.
  • Avoid undercooked meats, poultry, and fish, and unpasteurized dairy and juice.
  • Consult a dietitian to help you plan safe and healthy meals.

Resources We Trust

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. Neutropenia. Cleveland Clinic. June 9, 2022.
  2. Chemotherapy for Breast Cancer. American Cancer Society. October 27, 2021.
  3. Eating Safely with Neutropenia. Blood Cancer UK.
  4. Food Safety. U.S. Department of Agriculture. March 2025.
  5. Leftovers and Food Safety. U.S. Department of Agriculture. July 31, 2020.
  6. Neutropenic Diet. Memorial Sloan Kettering Cancer Center.
  7. Gulliver T et al. The Neutropenic Diet and Its Impacts on Clinical, Nutritional, and Lifestyle Outcomes for People with Cancer: A Scoping Review. Journal of Nutritional Science. October 10, 2024.
  8. Eating Healthy on the Go. American Cancer Society. August 11, 2025.
  9. A Nutrition Guide for Women with Breast Cancer. BC Cancer Agency.
Lynn Griger photo

Lynn Grieger, RDN, CDCES

Medical Reviewer

Lynn Grieger is a registered dietitian-nutritionist, certified diabetes care and education specialist, certified personal trainer, and certified health and wellness coach. She completed requirements to become a registered dietitian at Valparaiso University in 1987 and completed a dietetic internship at Ingalls Memorial Hospital in Harvey, Illinois, in 1988. 

Lynn brings her expertise in nutrition, exercise, and behavior change to her work in helping people reach their individual health and fitness goals. In addition to writing for Everyday Health, she has also written for websites and publications like Food and Health Communications, Today's Dietitian, iVillage.com, and Rodale Press. She has a passion for healthy, nutrient-dense, great-tasting food and for being outdoors as much as possible — she can often be found running or hiking, and has completed a marathon in every state.

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Stephanie Watson

Author
Stephanie Watson is a freelance health writer who has contributed to WebMD, AARP.org, BabyCenter, Forbes Health, Fortune Well, Time, Self, Arthritis Today, Greatist, Healthgrades, and HealthCentral. Previously, she was the executive editor of Harvard Women’s Health Watch and Mount Sinai’s Focus on Healthy Aging. She has also written more than 30 young adult books on subjects ranging from celebrity biographies to brain injuries in football.