Amyloidosis
Amyloidosis is a rare disease that occurs when a protein called amyloid builds up in your tissues and organs. Symptoms can include fatigue, weight loss, swelling in your legs and ankles, and shortness of breath. Treatment for amyloidosis can include chemotherapy, medications to reduce protein production, or organ transplantation. Lifestyle factors, such as attending to underlying conditions and adhering to prescribed treatments, are also important parts of managing the disease.

FAQ
Some forms of amyloidosis are hereditary, while other types are caused by external factors like inflammatory diseases, chronic infections, or long-term dialysis.
The main symptoms of amyloidosis include severe fatigue and weakness, dizziness upon standing, weight loss without trying, shortness of breath, and numbness or tingling in the hands or feet.
There's no cure for amyloidosis. Treatment focuses on managing symptoms and slowing progression.
Organs that may be affected by amyloidosis include the heart, kidneys, digestive tract, liver, spleen, and nerves.

Joy Tanaka, PhD
Medical Reviewer
Joy Tanaka, PhD, specializes in clinical molecular genetics. She is dedicated to integrating excellent clinical care with cutting-edge medical research for patients with rare and undiagnosed disorders, and is focused on pursuing questions at the interface between genetics and human disease with the goal of developing novel therapies and treatments.
Dr. Tanaka received her PhD from Yale University School of Medicine, where she was a Howard Hughes Medical Institute Medical Research Scholar and recipient of the George Robert Pfeiffer Fellowship for Translational Medicine. She completed her clinical fellowship in cytogenetics and clinical molecular genetics at Columbia University and New York Presbyterian Hospital, and is currently associate clinical laboratory director at Rady Children's Hospital Institute for Genomic Medicine in San Diego, California.

Anurag Sahu, MD
Medical Reviewer
Anurag Sahu, MD, is the director of the adult congenital heart program at Inova Health System in Fairfax, Virginia. Previously, he was an associate professor of medicine as well as an associate professor of radiology at Emory University in Atlanta, where he also served as director of cardiac intensive care.
He attended medical school at the University of Missouri in Kansas City in its combined six-year BA/MD program. He then completed his internal medicine residency at Washington Hospital Center in Washington, DC; fellowship training at Rush University in Chicago; and advanced training in cardiac imaging and adult congenital heart disease at The Ohio State University in Columbus.
Dr. Sahu has published book chapters on cardiovascular imaging as well as a variety of journal articles in publications including The Journal of Heart and Lung Transplant, JACC: Cardiovascular Interventions, and the Journal of Thoracic Imaging.
Among the places that his career has taken him, his favorite was Kauai, Hawaii, where he was the only cardiologist on the island.

Kalyan Banda, MD
Medical Reviewer
Dr. Kalyan Banda received his medical degree from India’s Christian Medical College in Vellore. During his time in both medical school and as an NIH Fogarty-Ellison global health fellow, his research focused on water, sanitation, and infectious diseases.
Dr. Banda completed his internship and residency in internal medicine, as well as his research fellowship on the role of cell surface sugars in human diseases, at the University of California in San Diego. He is currently a senior fellow at the University of Washington and the Fred Hutchinson Cancer Research Center, both in Seattle, where he is completing his clinical training in hematology and oncology while pursuing his passion for research on how cells become cancerous.

Allison M. Fout, PA-C
Medical Reviewer
Allison M. Fout, PA-C, has 20 years of experience as a Physician Assistant with a career rooted in orthopedic care. Since 2015, she has been a provider at Excelsior Orthopaedics in Buffalo, New York, specializing in sports medicine, joint replacements, fracture care, and a wide range of musculoskeletal conditions.
She works with patients across multiple age groups — from young athletes to aging adults — helping them recover function, reduce pain, and return to the activities they enjoy.
Her dedication to patient-centered care earns the trust of both her patients and colleagues. Beyond the clinic and operating room, she's involved in education and mentorship. She serves as a mentor to fellow clinicians and students alike and works as an adjunct instructor of orthopedics for the PA program at Daemen University, guiding and empowering the next generation of healthcare professionals as they develop their technical skills, knowledge, and confidence.

Chung Yoon, MD
Medical Reviewer

Rachana K. Gandhi Mehta, MBBS
Medical Reviewer
Rachana K. Gandhi Mehta, MBBS, is an associate professor in the department of neurology at Wake Forest University School of Medicine in Winston-Salem, North Carolina. She specializes in the diagnosis and management of neuromuscular disorders, with a clinical focus on conditions such as myasthenia gravis, autoimmune neuromuscular disorders, and amyloidosis-related neuropathy, and also conducts various electrodiagnostic procedures.
Dr. Mehta is a strong advocate for integrating research and patient care. She has published extensively in peer-reviewed journals, and her research interests include myasthenia gravis, chronic inflammatory demyelinating polyneuropathy (CIDP), amyloid neuropathy, and utilizing neuromuscular ultrasound for various neuromuscular disorders. In addition to her clinical and research endeavors, Dr. Mehta is actively involved in teaching and mentoring neuromuscular fellows, residents, and medical students.
She completed her medical degree (MBBS) at Pramukhswami Medical College, Sardar Patel University, India, followed by an internship and neurology residency at Cleveland Clinic Florida, where she served as chief resident. She then pursued advanced fellowship training in neuromuscular medicine at Duke University Medical Center in Durham, North Carolina. She is board-certified in neurology, neuromuscular medicine, and electrodiagnostic medicine.

Michelle Seguin, MD
Medical Reviewer
Michelle Seguin, MD, is a board-certified family medicine, lifestyle medicine, and certified functional medicine physician (IFMCP). She is a practicing physician at Root Functional Medicine, a leading telemedicine practice specializing in personalized, root-cause care.
Parveen Garg, MD MPH
Medical Reviewer
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